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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Pengabdian Masyarakat Bangsa
Cahyadi, Dzaky Raihan
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Pelatihan Pembuatan Suplemen Organik dari Olahan Rumput Laut Merah asal Desa Ruguk, Kec. Ketapang, Lampung Selatan Putri, Refsya Azanti; Saputra, Muhammad Yogi; Ayuwulanda, Aditya; Nareswari, Tantri Liris; Windari, Nurul Irna; Saeli, Pinka Mustika; A.L, Ihza Adzkiya Mubarak; Arrafi, Muhammad Zhafran; N.S, Yonatan Adi; Cahyadi, Dzaky Raihan
Jurnal Pengabdian Masyarakat Bangsa Vol. 1 No. 9 (2023): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v1i9.428

Abstract

Provinsi Lampung merupakan salah satu sentra penghasil rumput laut kering di Indonesia. Rumput laut dikenal dengan berbagai kandungan gizi yang berkhasiat untuk mengobati penyakit dan memenuhi kebutuhan nutrisi tubuh. Jenis rumput laut yang banyak dibudidaya yaitu rumput laut merah (Eucheuma cottoni). Namun, pemanfaatan rumput laut merah untuk dijadikan produk olahan yang sehat dan bernilai ekonomis masih belum dilakukan. Oleh karena itu, kegiatan pengabdian masyarakat ini dilakukan untuk membantu dan mengedukasi Masyarakat agar bisa mengoptimalkan potensi rumput laut merah menjadi produk suplemen herbal berupa serbuk dan gel yang dikombinasi dengan empon-empon sehingga bermanfaat untuk kesehatan dan bernilai ekonomis  tinggi. Kegiatan pelatihan ini diikuti oleh 21 orang masyarakat desa dan anggota kelompok tani Putra Laut. Bentuk kegiatan yang dilakukan yaitu penyuluhan, pendampingan  pembuatan produk, dan pelatihan kewirausahaan rumput laut merah kepada masyarakat Desa Ruguk, Lampung Selatan. Evaluasi dilakukan menggunakan penilaian kuisioner pre dan post tes yang menunjukkan bahwa terdapat peningkatan pengetahuan pada semua peserta mengenai materi dan pengolahan rumput laut menjadi produk herbal.
In Silico Analysis of Cucurbitacin IIa and Cucurbitacin IIb as Potential Modulators of Oxidative Stress Regulatory Proteins Sarmoko, Sarmoko; Suprahman, Nisa Yulianti; Putri, Refsya Azanti; Hakim, Ahmad Zammi Autadan; Cahyadi, Dzaky Raihan; Saputra, Muhammad Yogi
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp224-236

Abstract

Oxidative stress, resulting from imbalance between rective oxygen species (ROS) production and antioxidant defenses, contributes significantly to numerous pathological conditions, including inflammation, cancer and neurodegeneration. Natural compounds with antioxidant properties offer promising therapeutic potential. This study aims to investigate the potential of Cucurbitacin IIa and IIb to modulate oxidative stress regulatory proteins (NOS2, Lipoxygenase, KEAP1, and Xanthine oxidase) using molecular docking approaches. Target protein structures were retrieved from the RSCB Protein Data Bank. Ligand geometries were constructed and optimized using density functional theory. Molecular docking was performed using AutoDock 1.5.6 with a validated docking protocol (RPMS<2Å). Our results demonstrated favorable binding energies for both compounds with NOS2 (-9.75 and -9.57 kcal/mol) and KEAP1 (-8.52 and -9.34 kcal/mol), approaching the affinities of their respective native ligands. Moderate binding was observed with Lipoxygenase (-6.14 and -5.54 kcal/mol), while both compounds showed incompatibility with Xanthine oxidase, as evidenced by highly positive binding energies. The interaction between Cucurbitacins with NOS2, KEAP1 and Lipoxygenase was mediated through hydrogen and hydrophobic interaction. These findings provide mechanistic insight into their bioactivity and support further experimental studies for therapeutic development in oxidative stress-related disorders.Keywords: Cucurbitacin, Molecular docking, Oxidative stress, NOS2, KEAP1.
Co-Authors A.L, Ihza Adzkiya Mubarak Arrafi, Muhammad Zhafran Ayuwulanda, Aditya Hakim, Ahmad Zammi Autadan Muhammad Yogi Saputra N.S, Yonatan Adi Nisa Yulianti Suprahman Refsya Azanti Putri Saeli, Pinka Mustika Sarmoko Sarmoko Tantri Liris Nareswari Windari, Nurul Irna