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All Journal Jurnal Mandala Pharmacon Indonesia Pharmacy Reports Jurnal Pengabdian Masyarakat Bangsa
Saeli, Pinka Mustika
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Pelatihan Pembuatan Suplemen Organik dari Olahan Rumput Laut Merah asal Desa Ruguk, Kec. Ketapang, Lampung Selatan Putri, Refsya Azanti; Saputra, Muhammad Yogi; Ayuwulanda, Aditya; Nareswari, Tantri Liris; Windari, Nurul Irna; Saeli, Pinka Mustika; A.L, Ihza Adzkiya Mubarak; Arrafi, Muhammad Zhafran; N.S, Yonatan Adi; Cahyadi, Dzaky Raihan
Jurnal Pengabdian Masyarakat Bangsa Vol. 1 No. 9 (2023): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v1i9.428

Abstract

Provinsi Lampung merupakan salah satu sentra penghasil rumput laut kering di Indonesia. Rumput laut dikenal dengan berbagai kandungan gizi yang berkhasiat untuk mengobati penyakit dan memenuhi kebutuhan nutrisi tubuh. Jenis rumput laut yang banyak dibudidaya yaitu rumput laut merah (Eucheuma cottoni). Namun, pemanfaatan rumput laut merah untuk dijadikan produk olahan yang sehat dan bernilai ekonomis masih belum dilakukan. Oleh karena itu, kegiatan pengabdian masyarakat ini dilakukan untuk membantu dan mengedukasi Masyarakat agar bisa mengoptimalkan potensi rumput laut merah menjadi produk suplemen herbal berupa serbuk dan gel yang dikombinasi dengan empon-empon sehingga bermanfaat untuk kesehatan dan bernilai ekonomis  tinggi. Kegiatan pelatihan ini diikuti oleh 21 orang masyarakat desa dan anggota kelompok tani Putra Laut. Bentuk kegiatan yang dilakukan yaitu penyuluhan, pendampingan  pembuatan produk, dan pelatihan kewirausahaan rumput laut merah kepada masyarakat Desa Ruguk, Lampung Selatan. Evaluasi dilakukan menggunakan penilaian kuisioner pre dan post tes yang menunjukkan bahwa terdapat peningkatan pengetahuan pada semua peserta mengenai materi dan pengolahan rumput laut menjadi produk herbal.
Molecular docking analysis of flavonoid compounds from gandaria (Bouea macrophlla Griff) as potential alpha-glucosidase inhibitors Azzahrah, Qurrota A’yun; Novelina, Laras; Rosviena, Nyi Ayu Fayza; Saabirah, Ghania Parsa; Adilla, Annisa Rahma; Saeli, Pinka Mustika; Uswatunhasanah, Putri; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 1 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.75

Abstract

Diabetes mellitus represents a significant metabolic disorder with elevated global prevalence, necessitating development of effective antidiabetic therapies. This study investigates flavonoid compounds from gandaria (Bouea macrophylla Griff) as potential α-glucosidase inhibitors through molecular docking analysis. Eight flavonoid compounds were evaluated against human α-glucosidase enzyme (PDB ID: 2QMJ) using AutoDock Tools version 1.5.6. The methodology achieved validation with an RMSD value of 1.98 Å, confirming computational reliability. Lipinski's Rule of Five assessment identified four compounds meeting drug-likeness criteria for analysis. Quercetin demonstrated the strongest binding affinity among tested compounds with a binding energy of -4.72 kcal/mol, compared to the native ligand N-acetylglucosamine at -5.12 kcal/mol. Interaction analysis revealed quercetin formed significant hydrogen bonds with key active site residues including Lys389, Asn393, and Asn417, indicating potential competitive inhibition mechanisms. All flavonoid compounds exhibited consistent binding patterns with Lys389 serving as a critical interaction site. These computational findings establish quercetin as the most promising flavonoid candidate for α-glucosidase inhibition, supporting its potential as a natural antidiabetic agent.
Uji Stabilitas dan Aktivitas Sediaan Patch Herbal Anti-Acne Ekstrak Etanol Daun Gaharu Simanullang, Gayatri; Ramadhani, Untia Kartika Sari; Suprahman, Nisa Yulianti; Maretta, Gres; Syafitri, Dewi Rana; Saeli, Pinka Mustika; Ashafila, Tsalsha
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.439

Abstract

Acne is a skin condition characterized by the formation of skin bumps due to bacterial activity. Secondary metabolite compounds found in Gaharu leaves, such as flavonoids known for their antibacterial properties. This research aims to assess the physical and chemical stability of an anti-acne patch containing ethanol extract from Gaharu leaves and chitosan polymer. Additionally, this research aims to evaluate the antibacterial effectiveness of the anti-acne patch against Propionibacterium acnes. The experimental approach involves stability testing through cycling tests, observation of physical and chemical properties before and after stability tests, and antibacterial activity testing against P. acnes. The results from the stability test indicate overall stability in organoleptic aspects, thickness, folding ability, weight consistency, moisture content, vapor transmission, and moisture absorption of the anti-acne patch. However, instability is noted in the pH of the preparation. The antibacterial activity test reveals that the entire formulation exhibits antibacterial properties against P. acnes. Furthermore, there is a positive correlation between the increased concentration of ethanol extract from Gaharu leaves or chitosan polymer and the heightened barrier zone value.
Co-Authors A.L, Ihza Adzkiya Mubarak Adilla, Annisa Rahma Anjar Hermadi Saputro Arrafi, Muhammad Zhafran Ashafila, Tsalsha Ayuwulanda, Aditya Azzahrah, Qurrota A’yun Cahyadi, Dzaky Raihan Gres Maretta, Gres Muhammad Yogi Saputra N.S, Yonatan Adi Nisa Yulianti Suprahman Novelina, Laras Ramadhani, Untia Kartika Sari Refsya Azanti Putri Rosviena, Nyi Ayu Fayza Saabirah, Ghania Parsa Simanullang, Gayatri Syafitri, Dewi Rana Tantri Liris Nareswari Uswatunhasanah, Putri Windari, Nurul Irna Winni Nur Auli