Article Per Year (5 Year)
p-Index From 2021 - 2026
2.33
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Nusantara Science and Technology Proceedings Jurnal Pustaka Mitra : Pusat Akses Kajian Mengabdi Terhadap Masyarakat TeknoKreatif: Jurnal Pengabdian kepada Masyarakat
Nisa Yulianti Suprahman
Department Of Pharmacy, Faculty Of Science, Institut Teknologi Sumatera, Lampung, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
Mannitol Production from Fructose by Using Resting Cells of Methylotrophic Yeasts Nisa Yulianti Suprahman; Khairul Basyar; Herman Suryadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.272-278

Abstract

Background: Mannitol is a polyol sugar widely used in pharmaceutical and food industries which can be produced by bioconversion. Using of resting cells and methanol as a carbon source are strategies to increase the efficiency of mannitol production by increasing NAD(P)H needed in the reduction process. Objectives: This research aimed to optimize bioconversion condition by using resting cells of methylotrophic yeasts with methanol and fructose as carbon source and substrate, respectively. Methods:  Several isolates were used including Candida sp, Debaryomyces nepalensis and Debaryomyces hansenii and three species suspected to be yeast isolated from a local paddy field. The methylotrophic characteristic of the yeasts was screened by turbidometry. The optimization of fermentation condition was conducted by varying cultivation time (24-96 hours), resting cell concentration (30-140 mg/mL), fructose concentration (7.5-15%), ammonium sulphate concentration (0.25-0.75%) and aeration condition (50-80%). Quantitative analysis of the mannitol was conducted by HPLC with NH2 column and Refractive Index Detector. Results: D. hansenii showed the highest yield value in mannitol production (23.17%), followed by D. nepalensis, Isolate A and Candida sp. (6.52%, 6.50% and 4.38%, respectively). Variation of bioconversion condition using D. hansenii showed that the highest resting cell concentration (140 mg/mL) incubated for 72 hours, moderate fructose concentration (10%), the highest ammonium sulphate concentration (0.75%) and moderate aeration condition (70%) would result in the highest yield value of mannitol (60%). Conclusion: This finding showed the potency of D. hansenii in mannitol production and gave preliminary information of its optimum fermentation condition.
Molecular Docking Analysis of Zerumbone Derivatives as XIAP-BIR3 Inhibitor for Anticancer Agent Winni Nur Auli; Nisa Yulianti Suprahman; Riri Fauziyya; Sarmoko; Arif Ashari; Safia Fazila; Qurrota A`yun Azzahrah; Romualdo Pasaribu; Putri Liswatini; Ihza Adzkiya Mubarak Al-Husni; Dinda Naila Dhiya Salsabila
Nusantara Science and Technology Proceedings Multi-Conference Proceeding Series F
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4602

Abstract

Cancer is the second most common cause of death worldwide. Common therapies used to treat cancer include radiation, chemotherapy, and surgery. However, resistance to treatment often gives a challenging problem, and new alternative therapies derived from natural compounds are needed. Zerumbone is terpenoid compound with various biological activities, including anti-tumor and anti-cancer. This study aims to investigate the activity of Zerumbone and its derivatives against the XIAP-BIR3 protein. The target protein used PDB ID: 4KMP as inhibitor of XIAP-BIR3. There are 21 zerumbon derivatives retrieved from published article. Docking of zerumbone derivatives was performed using Autodock 1.5.6. Molecular docking result showed derivative 6 of Zerumbone has potential as an anti-cancer agent with a binding energy of -7.84 kcal/mol; meanwhile, the reference inhibitor has a binding energy of -5.21 kcal/mol. These results of the study indicate that the development of inhibitor XIAP-BIR3 may be a potential strategy in cancer treatment and zerumbone derivatives are predicted to be potential candidates that can be analyzed further.
PEMBERDAYAAN USAHA EKONOMI KREATIF MELALUI PENDEKATAN PELATIHAN DAN PENDAMPINGAN USAHA PEMBUATAN PRODUK JAMU KEKINIAN SEBAGAI UPAYA PENCAPAIAN SDGS DI KELURAHAN YOSOREJO, KOTA METRO Yulianti Suprahman, Nisa; Hidayaturahmah, Rizky; Hermadi Saputro, Anjar; Irna Windari, Nurul; Sarmoko, Sarmoko
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 11 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i11.4924-4929

Abstract

Sebagian besar masyarakat di Kelurahan Yosorejo, Kecamatan Metro Timur memiliki pekarangan rumah atau kebun yang sebagian ditanami tanaman obat keluarga (TOGA) seperti kunyit, temulawak, temugiring, jahe kencur, sirih, kecombrang, sambiloto, binahong dan lain-lain. Kendala utama yang dihadapi adalah belum optimalnya pemanfaatan tanaman obat keluarga (TOGA), rendahnya pengetahuan dan teknologi untuk membuat jamu kekinian yang berkualitas, jumlah diproduksi masih terbatas, jenis dan variasi produk juga masih sedikit dan market share masih rendah. Selain produk jamu, tanaman TOGA belum dilakukan pengembangan teknologi menjadi produk herbal yang bernilai ekonomi tinggi seperti sabun.  Faktor tersebut yang membuat industri jamu tradisional tidak bisa berkembang. Maksud Pengabdian Kepada Masyarakat (PKM) adalah mengembangkan usaha jamu kekinian pada Ibu-ibu PKK kelurahan Yosorejo agar dapat membantu meningkatkan pendapatan masyarakat. Tujuannya Mengembangkan dan memperbaiki usaha jamu tradisional menjadi jamu kekinian yang modern yang bisa mengangkat salah satu produk warisan leluhur turun temurun. Dengan cara memproses tahap-tahapan pembuatan produk secara benar, mengedukasi Ibu-Ibu PKK untuk giat mengembangkan usaha yang menguntungkan dan memiliki peluang yang sangat terbuka. Kegiatan dilakukan dengan metode pelatihan secara langsung serta pembagian produk jamu kekinian dan sabun organik ke masyarakat. Hasil dari kegiatan ini adalah masyarakat dapat memahami dan mampu membuat jamu dan sabun organik berbahan dasar tanaman TOGA.
Uji Stabilitas dan Aktivitas Sediaan Patch Herbal Anti-Acne Ekstrak Etanol Daun Gaharu Simanullang, Gayatri; Ramadhani, Untia Kartika Sari; Suprahman, Nisa Yulianti; Maretta, Gres; Syafitri, Dewi Rana; Saeli, Pinka Mustika; Ashafila, Tsalsha
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.439

Abstract

Acne is a skin condition characterized by the formation of skin bumps due to bacterial activity. Secondary metabolite compounds found in Gaharu leaves, such as flavonoids known for their antibacterial properties. This research aims to assess the physical and chemical stability of an anti-acne patch containing ethanol extract from Gaharu leaves and chitosan polymer. Additionally, this research aims to evaluate the antibacterial effectiveness of the anti-acne patch against Propionibacterium acnes. The experimental approach involves stability testing through cycling tests, observation of physical and chemical properties before and after stability tests, and antibacterial activity testing against P. acnes. The results from the stability test indicate overall stability in organoleptic aspects, thickness, folding ability, weight consistency, moisture content, vapor transmission, and moisture absorption of the anti-acne patch. However, instability is noted in the pH of the preparation. The antibacterial activity test reveals that the entire formulation exhibits antibacterial properties against P. acnes. Furthermore, there is a positive correlation between the increased concentration of ethanol extract from Gaharu leaves or chitosan polymer and the heightened barrier zone value.
Bioinformatic and Molecular Docking Study of Zerumbone and Its Derivates against Colorectal Cancer Fauziyya, Riri; Auli, Winni Nur; Suprahman, Nisa Yulianti; Sarmoko, Sarmoko; Ashari, Arif; Alsadila, Kalista; Agustin, Lanita; Fazila, Safia; Zahra, Miralda; Pane, Esteria Christina; Sukrasno, Sukrasno
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp39-48

Abstract

The prevalence of colorectal cancer (CRC) is ranked third among all cancer types in both men and women, highlighting the urgency for drug exploration. Zerumbone and its derivatives have gained attention for their ability to inhibit angiogenesis, invasion, and metastasis and have been tested for their efficacy against various cancer cells. This study aimed to investigate the potential targets and mechanism of action of zerumbone derivatives in colon cancer invasion and migration. Bioinformatic analysis was conducted using STITCH and STRING to identify potential target genes, and molecular docking was used to search for anticancer candidates from 20 zerumbone derivatives. The results revealed that six proteins were targeted by zerumbone derivatives, including XIAPBIR3 (1TFT), AKT1 (3O96), JAK2 (6VGL), HASP90AA (2XJX), MDM2 (4MDN), and XIAPBIR2 (4KJU). Compound 4 was found to have a lower binding energy than zerumbone as well as AZD5363 (pan-Akt inhibitor) when interacting with the protein target AKT1. This makes it the most promising candidate among the zerumbone derivatives for treating colorectal cancer. Further development, such as the addition of an amine functional group, is expected to improve the potency of this molecule through the formation of hydrogen bonds and other interactions with lower bond energy.Keywords: Bioinformatic, molecular docking, zerumbone derivatives, colorectal cancer.
In Silico Analysis of Cucurbitacin IIa and Cucurbitacin IIb as Potential Modulators of Oxidative Stress Regulatory Proteins Sarmoko, Sarmoko; Suprahman, Nisa Yulianti; Putri, Refsya Azanti; Hakim, Ahmad Zammi Autadan; Cahyadi, Dzaky Raihan; Saputra, Muhammad Yogi
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp224-236

Abstract

Oxidative stress, resulting from imbalance between rective oxygen species (ROS) production and antioxidant defenses, contributes significantly to numerous pathological conditions, including inflammation, cancer and neurodegeneration. Natural compounds with antioxidant properties offer promising therapeutic potential. This study aims to investigate the potential of Cucurbitacin IIa and IIb to modulate oxidative stress regulatory proteins (NOS2, Lipoxygenase, KEAP1, and Xanthine oxidase) using molecular docking approaches. Target protein structures were retrieved from the RSCB Protein Data Bank. Ligand geometries were constructed and optimized using density functional theory. Molecular docking was performed using AutoDock 1.5.6 with a validated docking protocol (RPMS<2Å). Our results demonstrated favorable binding energies for both compounds with NOS2 (-9.75 and -9.57 kcal/mol) and KEAP1 (-8.52 and -9.34 kcal/mol), approaching the affinities of their respective native ligands. Moderate binding was observed with Lipoxygenase (-6.14 and -5.54 kcal/mol), while both compounds showed incompatibility with Xanthine oxidase, as evidenced by highly positive binding energies. The interaction between Cucurbitacins with NOS2, KEAP1 and Lipoxygenase was mediated through hydrogen and hydrophobic interaction. These findings provide mechanistic insight into their bioactivity and support further experimental studies for therapeutic development in oxidative stress-related disorders.Keywords: Cucurbitacin, Molecular docking, Oxidative stress, NOS2, KEAP1.
PEMBERDAYAAN USAHA EKONOMI KREATIF MELALUI PENDEKATAN PELATIHAN DAN PENDAMPINGAN USAHA PEMBUATAN PRODUK JAMU KEKINIAN SEBAGAI UPAYA PENCAPAIAN SDGS DI KELURAHAN YOSOREJO, KOTA METRO Yulianti Suprahman, Nisa; Hidayaturahmah, Rizky; Hermadi Saputro, Anjar; Irna Windari, Nurul; Sarmoko, Sarmoko
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 11 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i11.4924-4929

Abstract

Sebagian besar masyarakat di Kelurahan Yosorejo, Kecamatan Metro Timur memiliki pekarangan rumah atau kebun yang sebagian ditanami tanaman obat keluarga (TOGA) seperti kunyit, temulawak, temugiring, jahe kencur, sirih, kecombrang, sambiloto, binahong dan lain-lain. Kendala utama yang dihadapi adalah belum optimalnya pemanfaatan tanaman obat keluarga (TOGA), rendahnya pengetahuan dan teknologi untuk membuat jamu kekinian yang berkualitas, jumlah diproduksi masih terbatas, jenis dan variasi produk juga masih sedikit dan market share masih rendah. Selain produk jamu, tanaman TOGA belum dilakukan pengembangan teknologi menjadi produk herbal yang bernilai ekonomi tinggi seperti sabun.  Faktor tersebut yang membuat industri jamu tradisional tidak bisa berkembang. Maksud Pengabdian Kepada Masyarakat (PKM) adalah mengembangkan usaha jamu kekinian pada Ibu-ibu PKK kelurahan Yosorejo agar dapat membantu meningkatkan pendapatan masyarakat. Tujuannya Mengembangkan dan memperbaiki usaha jamu tradisional menjadi jamu kekinian yang modern yang bisa mengangkat salah satu produk warisan leluhur turun temurun. Dengan cara memproses tahap-tahapan pembuatan produk secara benar, mengedukasi Ibu-Ibu PKK untuk giat mengembangkan usaha yang menguntungkan dan memiliki peluang yang sangat terbuka. Kegiatan dilakukan dengan metode pelatihan secara langsung serta pembagian produk jamu kekinian dan sabun organik ke masyarakat. Hasil dari kegiatan ini adalah masyarakat dapat memahami dan mampu membuat jamu dan sabun organik berbahan dasar tanaman TOGA.
UPAYA PENINGKATAN KESEHATAN MASYARAKAT MELALUI EDUKASI DAPATKAN, GUNAKAN, SIMPAN, DAN BUANG (DAGUSIBU) OBAT DI DUSUN 006 WAY HUI LAMPUNG SELATAN Nadiah, Syaadatun; Mayefis, Delladari; Oktariza, Yasinda; Hidayaturahmah, Rizky; Hasanah, Uswatun; Dalili Akhmad, Atika; Mukaromah Khoirunnisa, Sudewi; Yulianti Suprahman, Nisa; Dirga, Dirga; Sarmoko, Sarmoko
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 9, No 1 (2026): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v9i1.%p

Abstract

DAGUSIBU merupakan konsep fundamental untuk meningkatkan literasi obat di masyarakat.Rendahnya literasi kesehatan dan kepatuhan terhadap terapi obat merupakan tantangan utama dalam pengelolaan penyakit tidak menular, terutama pada masyarakat dengan akses terbatas terhadap layanan kesehatan. Program Pengabdian kepada Masyarakat (PkM) ini bertujuan meningkatkan pemahaman masyarakat Dusun 006 Way Hui, Lampung Selatan mengenai penggunaan obat yang benar, kepatuhan minum obat, serta pentingnya pemeriksaan kesehatan rutin melalui pendekatan edukasi partisipatif. Kegiatan mencakup penyuluhan interaktif, praktik penyusunan jadwal obat, dan pemeriksaan kesehatan dasar meliputi gula darah, kolesterol, dan asam urat. Evaluasi dilakukan menggunakan pre-test dan post-test serta observasi praktik peserta. Sebanyak 28 peserta mengikuti pemeriksaan kesehatan dan 20 peserta menyelesaikan kedua tes evaluatif. Hasil menunjukkan peningkatan skor pengetahuan sebesar 52,22% dengan perbedaan signifikan (p 0,001). Pemeriksaan kesehatan juga mengungkapkan beberapa peserta memiliki parameter di atas batas normal, sehingga diberi konseling individual mengenai pengelolaan gaya hidup sehat. Respons peserta sangat positif, ditunjukkan oleh tingginya keterlibatan dalam diskusi dan praktik. Secara keseluruhan, pendekatan integratif yang menggabungkan edukasi, praktik, dan pemeriksaan kesehatan terbukti efektif dalam meningkatkan literasi obat, kesadaran kesehatan, serta motivasi peserta untuk menjaga kesehatan secara preventif. Program serupa direkomendasikan untuk dilaksanakan secara berkelanjutan guna memperkuat kemandirian kesehatan masyarakat pedesaan
Ivabradine in Heart Failure with Reduced Ejection Fraction (HFrEF): A Narrative Review of Clinical Outcomes Hidayaturahmah, Rizky; Khoerunisa, Erin; Suprahman, Nisa Yulianti; Novitasari, Fia
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 16, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.88590

Abstract

Background: Therapy for heart failure with reduced ejection fraction (HFrEF) patients is complex, involving several combinations of treatments, but there are still some problems, such as rehospitalization, reduced ejection fraction values, increased heart rate, and decreased quality of life. Ivabradine, a selective heart rate-lowering agent, offers adjunctive therapeutic benefits.Objective: This study aims to determine the characteristics of HFrEF patients who received additional therapy with ivabradine and to determine how ivabradine affects their clinical outcomes.Methods: This narrative review searched articles on PubMed, Cochrane Library, Google Scholar, and ScienceDirect. The research was limited to randomized controlled trial articles, observational studies, and cohorts with international and national English and/or Indonesian articles published in the last 10 years.Results: Twenty-eight studies (n=36,765) met the problem formulation and inclusion criteria were analyzed. Patients receiving ivabradine were predominantly male (74.9%), aged 56-65 years (81.9%), and had a history of smoking. Most patients had heart rate ≥70 bpm (75.4%), LVEF ≤30% (55.3%), BMI ≥28 kg/m² (87.1%), and NYHA class II-III (85.5%). The addition of ivabradine to the clinical outcome of HFrEF patients reduces heart rate (15.7 bpm), blood pressure (SBP: -4.4 mmHg; DBP: -0.9 mmHg), rehospitalization, and mortality, while improving LVEF and stroke volume, and quality of life. Adverse effects included manageable bradycardia and transient visual disturbances.Conclusion: Ivabradine effectively improves clinical outcomes in HFrEF patients as adjunct therapy, with significant benefits in cardiac function, symptom control, and prognosis.
DEMONSTRASI PEMBUATAN JAMU PENAMBAH NAFSU MAKAN PADA ANAK SEKOLAH DASAR KELAS V DAN VI SDN GEDUNG HARAPAN, LAMPUNG SELATAN Syaadatun Nadiah; Refsya Azanti Putri; Dewi Damayanti Abdul Karim; Gayatri Simanullang; Mubarika Sekarsari Yusuf; Naura Nurnahari; Nisa Yulianti Suprahman
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 9, No 5 (2026): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v9i5.1987-1991

Abstract

Nafsu makan yang baik sangat penting bagi kesehatan anak usia sekolah dasar karena berpengaruh pada kecukupan gizi, pertumbuhan, dan kecerdasan. Namun, rendahnya nafsu makan masih menjadi masalah yang sering dijumpai dan berisiko menurunkan kualitas kesehatan anak. Untuk itu, kegiatan pengabdian kepada masyarakat di SDN Gedung Harapan, Lampung Selatan dilakukan dengan memperkenalkan jamu penambah nafsu makan berbahan alami, yaitu temulawak, lemon, meniran, sereh, dan madu. Kegiatan meliputi optimasi produk, penyusunan materi, serta demonstrasi interaktif bersama siswa kelas 5 dan 6. Hasil evaluasi melalui pre-test dan post-test menunjukkan adanya peningkatan signifikan pemahaman siswa mengenai manfaat jamu (p0,05), sehingga kegiatan ini efektif meningkatkan kesadaran dan keterampilan anak dalam memanfaatkan tanaman obat sebagai alternatif sehat dan aman untuk mendukung nafsu makan serta kesehatan mereka
Co-Authors Agustin, Lanita Alsadila, Kalista Anjar Hermadi Saputro Arif Ashari Arif Ashari Ashafila, Tsalsha Cahyadi, Dzaky Raihan Dalili Akhmad, Atika Damayanti Abdul Karim, Dewi Dinda Naila Dhiya Salsabila Dirga Dirga Dirga Dirga Fauziyya, Riri Fazila, Safia Gayatri Simanullang Gres Maretta, Gres Hakim, Ahmad Zammi Autadan Herman Suryadi Hidayaturahmah, Rizky Ihza Adzkiya Mubarak Al-Husni Irna Windari, Nurul Khairul Basyar Khoerunisa, Erin Mayefis, Delladari Mubarika Sekarsari Yusuf Muhammad Yogi Saputra Mukaromah Khoirunnisa, Sudewi Nadiah, Syaadatun Novitasari, Fia Novrilia Atika Nabila Novrilia Atika Nabila Nurnahari, Naura Nurul Irna Windari Oktariza, Yasinda Pane, Esteria Christina Putri Amelia Rooswita Putri Amelia Rooswita Putri Liswatini Qurrota A`yun Azzahrah Ramadhani, Untia Kartika Sari Refsya Azanti Putri Refsya Azanti Putri Riri Fauziyya Riri Fauziyya Rizky Hidayaturahmah Romualdo Pasaribu Rooswita, Putri Amelia Saeli, Pinka Mustika Safia Fazila Sarmoko Sarmoko Sarmoko Simanullang, Gayatri Sukrasno Sukrasno Syaadatun Nadiah Syafitri, Dewi Rana Uswatun Hasanah Winni Nur Auli Zahra, Miralda