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Aryani Hayuningtyas, Ria
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Peran igf-1 dan let-7 dalam morfogenesis gigi ditinjau dari sel punca mesenkimal pulpa gigi Endriyana, Jessica; Aryani Hayuningtyas, Ria
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.19136

Abstract

Tooth development is a complex process involving the interaction between dental epithelium and mesenchymal tissues. IGF-1 plays a crucial role in regulating cell proliferation, differentiation, apoptosis, and migration. Its significance is particularly notable during the proliferation and differentiation stages of root development, as well as in the stem cells derived from the apical papilla responsible for root pulp and dentin formation. IGF-1 exhibits osteoconductive potential in bone healing by modulating osteoclasts in bone resorption and osteoblasts in bone formation. Stem cells from dental pulp or apical papilla represent a mesenchymal stem cell or progenitor population that forms calcium nodules in osteo/odontogenic media. This study aims to elucidate the roles of IGF-1 and Let-7 in tooth morphogenesis, utilizing the PRISMA guidelines for data collection. A total of 12 literature sources were identified, with 3 articles published in the last 5 years. Only 5 articles were selected for inclusion in this study. Further exploration of IGF-1/IGF-1R/hsa-let-7c modulation in odonto/osteogenic differentiation holds promise for future tooth regeneration. IGF-1 enhances the size of tooth bud cultures, suggesting potential applications in genetic engineering for tooth morphogenesis. IGF-1 plays a crucial role in odontogenic proliferation and differentiation.
Insights into periodontitis: pathogenesis, host response, and antibiotic strategies Aryani Hayuningtyas, Ria; Endriyana, Jessica; Natassya, Priska
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.19185

Abstract

This paper provides a comprehensive exploration of periodontitis, a persistent and multifaceted inflammatory condition impacting tooth-supporting structures. The authors investigate the intricate relationship between causative factors, local microbiota, and the host immune response. The disarrayed regulation of cytokines, specifically IL-1, IL-6, and TNF, is highlighted for its pivotal role in triggering or hastening periodontitis onset. The study delves into the host response, emphasizing the delicate equilibrium needed between the immune system and microbiota. The categorization of periodontal pathogenic bacteria, with a focus on the highly pathogenic Phorphyromonas gingivalis and its virulence factors, is explored. Antibiotic efficacy in the context of rising resistance is discussed, encompassing commonly used antibiotics and proposing alternative strategies like plant extracts and bacteriocins. The study advocates for comprehensive therapeutic approaches that integrate antibiotics with alternative methods to effectively address the complex nature of periodontal diseases
Ekstrak Daun Tapak Dara sebagai Potensi Bahan Antikanker terhadap Sel Kanker Mulut Amalia Isnaeni, Nur; Sandra, Ferry; Aryani Hayuningtyas, Ria
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.20819

Abstract

Latar Belakang: Kanker rongga mulut merupakan salah satu keganasan yang paling sering terjadi di negara berkembang dan juga pada negara maju. Catharanthus roseus sering digunakan oleh masyarakat sebagai pengobatan tradisional dan berpotensi sebagai terapi alternatif pada perawatan kanker rongga mulut karena memiliki zat antioksidan. Tujuan: Review ini bertujuan untuk melihat kemungkinan penelitian masa depan tentang kanker mulut menggunakan ekstrak etanol daun C. roseus.  Metode: Referensi pada review ini menggunakan pencarian jurnal terkait di PubMed, Google Scholar, laporan resmi dan jurnal kesehatan lainnya dengan kata kunci pencarian “kanker mulut”, “antikanker”, “Catharanthus roseus”, “antioksidan” dan “apoptosis” dari tahun 2008-2022. Hasil Penelitian: Daun C. roseus sering digunakan masyarakat sebagai obat tradisional. Dilaporkan kegunaannya dalam pengobatan tradisional sebagai obat antibakteri, antioksidan, antihelmintik, antihiperglikemik, antifungi, antidiarrheal. C. roseus juga dilaporkan memiliki kemampuan dalam mengurangi viabilitas dan menginduksi apoptosis pada sel raji (kanker kepala dan leher), kanker serviks (sel HeLa), dan kanker payudara (sel MCF-7). Namun, belum dilakukan penelitian tentang potensi C. roseus sebagai bahan antikanker pada kasus kanker mulut.  Kesimpulan: Berdasarkan temuan, dapat disimpulkan bahwa daun C. roseus mampu berperan sebagai agen antikanker karena senyawa yang terkandung didalamnya. Penelitian lebih lanjut diperlukan untuk melihat aktivitas antikanker C. roseus terhadap kanker mulut.
Peran Allium sativum dalam menanggulangi patogen rongga mulut Utomo, Bella; Aryani Hayuningtyas, Ria; Nugrogo, Didi
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.20912

Abstract

Allium sativum is known as a bulbous plant that is produced all over the world. Apart from being used as a cooking spice, Allium sativum is acknowledged to have a variety of medical benefits, especially in terms of its antibacterial properties. The active compounds that contribute to its antibacterial effect, such as allicin, alliin, ajoene, flavonoids, saponins, tannins, steroids, and triterpenoids, work together to overcome various types of microorganisms, including Gram-positive and Gram-negative bacteria. Allium sativum extract has been demonstrated in numerous studies to have strong antibacterial activity, indicating that it can be used as a natural remedy for oral health issues.  
Co-Authors Amalia Isnaeni, Nur Endriyana, Jessica Ferry Sandra Natassya, Priska Nugrogo, Didi Utomo, Bella