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All Journal Jurnal Anestesi Perioperatif Solo Journal of Anesthesi, Pain and Critical Care Jurnal Komplikasi Anestesi
Meta Restu Synthana
Departemen Anestesiologi Dan Terapi Intensif, Fakultas Kedokteran, Kesehatan Masyarakat, Dan Keperawatan, Universitas Gadjah Mada, Yogyakarta, Indonesia
Chemical Engineering, Chemistry & Bioengineering Education Health Professions Medicine & Pharmacology Nursing Public Health

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Terapi Oksigen Hiperbarik Synthana, Meta Restu; Wisudarti, Calcarina Fitriani Retno; Pratomo, Bhirowo Yudo
Jurnal Komplikasi Anestesi Vol 4 No 2 (2017): Volume 4 Number 2 (2017)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v4i2.7296

Abstract

Terapi oksigen hiperbarik merupakan terapi dengan memberikan 100% oksigen pada dua sampai tiga kali dari tekanan pada level air laut. Terapi oksigen hiperbarik efektif dalam mengatasi berbagai penyakit antara lain luka karena trauma akut, ulserasi yang tidak membaik dengan terapi, crush injury, luka bakar, gas gangren, dan sindrom kompartemen dapat pula digunakan pada kasus-kasus keracunan gas misal keracunan gas karbonmonoksida. Terapi oksigen hiperbarik memiliki komplikasi dan efek toksik karena hiperoksia. Terapi ini sering digunakan pada pasien-pasien kritis misal karena keracunan karbonmonoksida, luka bakar, gas gangren, abses intrakranial, emboli, sehingga klinisi khususnya anestesiologist perlu mengetahui mekanisme, efek serta komplikasi terapi oksigen hiperbarik.
Manajemen Extracorporeal Membrane Oxygenation (ECMO) pada Pasien COVID-19 Derajat Kritis Synthana, Meta Restu; Kurniawaty, Juni; Wisudarti, Calcarina Fitriani Retno
Jurnal Komplikasi Anestesi Vol 10 No 2 (2022)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v10i2.8304

Abstract

We reported 42 years old male patient with weight 84 kg, height 167 cm, and BMI of 30.1 kg/m2 with a diagnosis of severe COVID-19 and ARDS. The patient was previously known to have comorbids of type 2 DM, stage 1 hypertension, cardiac arrhythmias, and grade 1 obesity. On the 7th day of care, the patient clinically and radiologically worsened and we decided to intubate and support with mechanical ventilation. An ECMO indication was assessed, the patient was indicated to have ECMO, so that ECMO was installed immediately after the patient was intubated. ECMO was successfully running 7 hours after the patient was intubated. During hospitalized the patient also received renal replacement therapy, hemadsorption therapy, and plasma exchange. The patient deceased on 31st day of ECMO.
The Correlation Between Syndecan-1 Post Cardiopulmonary Bypass and Duration of Ventilator Use in Open Heart Surgery Patients at Dr. Sardjito General Hospital, Yogyakarta Fatmi Eka Putri; Synthana, Meta Restu; Kurniawaty, Juni
Jurnal Komplikasi Anestesi Vol 13 No 2 (2026)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v13i2.29233

Abstract

Background: Open heart surgery involves the use of a cardiopulmonary bypass machine (CBP) to replace the heart and lungs during surgery. The use of CBP can damage the endothelial glycocalyx, which triggers increased levels of syndecan-1, an indicator of endothelial degradation. Elevated syndecan-1 levels are associated with various complications, such as coagulation disorders, edema, and organ dysfunction. In the lungs, endothelial glycocalyx damage can lead to edema and lung parenchymal damage, which can impair overall lung function and lead to a decreased PaO2/FiO2 ratio, requiring prolonged postoperative ventilator use.Objective: This study aimed to determine the relationship between post-CBP syndecan-1 levels and the duration of ventilator use in open heart surgery patients at Dr. Sardjito General Hospital, Yogyakarta.Methods: This study was a prospective, analytical, observational cohort study conducted at Dr. Sardjito General Hospital, Yogyakarta. The sample consisted of adult patients undergoing open heart surgery, with the exclusion criteria being patients using preoperative mechanical assist devices. Syndecan-1 levels were measured using the ELISA method using the Elabscience Human SDC1 kit. Data were analyzed using SPSS. Bivariate and multivariate analyses were also performed to evaluate factors influencing ventilator duration.Results: The study was conducted on 34 subjects with a mean age of 46 ± 13.71 years. The average CPB duration was 92.94 ± 47.57 minutes, with preoperative syndecan-1 levels of 8.86 ± 5.08 ng/ml, while post-CPB levels were 11.74 ± 3.71 ng/ml, with delta syndecan-1 levels of 2.87 ± 4.18 ng/ml.
Superior Vena Cava Obstruction After Pediatric Cardiac Surgery: A Case Series Synthana, Meta Restu; Wisudarti, Calcarina Fitriani Retno; Kurniawaty, Juni; Deviatika, Fiandila Elvana
Jurnal Anestesi Perioperatif Vol 14, No 1 (2026)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15851/jap.v14n1.4510

Abstract

Background: Superior vena cava (SVC) obstruction is a rare but potentially life–threatening complication following pediatric cardiac surgery, particularly in patients with congenital heart disease. Mechanical factors related to central venous catheterization and underlying venous anomalies may increase the risk of this condition.Case: We reported a case series of three pediatric patients who developed postoperative SVC obstruction following corrective cardiac surgery and were managed in the intensive care unit (ICU). All patients underwent insertion of a central venous catheter (CVC) via the internal jugular vein for perioperative hemodynamic support. Postoperatively, all patients developed clinical manifestations consistent with SVC obstruction, including facial and upper extremity edema, venous congestion, hemodynamic instability, and reduced urine output. Vascular ultrasonography confirmed partial to severe SVC obstruction in all cases. Two patients had associated anatomical variations, including a persistent left SCV, which may have contributed to altered venous drainage. Management strategies included CVC repositioning or removal, anticoagulation therapy, and surgical release of the obstruction when indicated. These interventions resulted in clinical and hemodynamic improvement in all affected patients.Discussion: This case series highlights the importance of recognizing mechanical and anatomical risk factors for SVC obstruction in pediatric cardiac surgery, including catheter size, tip position, and congenital venous anomalies.Conclusion: careful selection of CVC size, optimal tip placement, and ultrasound guidance for catheter positioning and postoperative assessment may help prevent this serious complication. Early diagnosis and timely intervention are essential to reduce morbidity and improve outcomes in this vulnerable population.
Extracorporeal Liver Support in Liver Failure: A Comprehensive Review of MARS, SPAD, Prometheus, ADVOS, and Bioartificial Systems Synthana, Meta Restu; Jufan, Akhmad Yun; Wisudarti, Calcarina Fitriani Retno; Deviatika, Fiandila Elvana
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 5, No 2 (2025): October 2025
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v5i2.107158

Abstract

Background : Acute and chronic liver failure are life-threatening conditions often requiring liver transplantation as definitive therapy. To delay or substitute the need for transplantation, various extracorporeal liver support systems have been developed. This article aims to review current artificial and bioartificial liver support systems including the Molecular Adsorbent Recirculating System (MARS), Single Pass Albumin Dialysis (SPAD), Prometheus, ADVanced Organ Support (ADVOS), and Bioartificial Liver (BAL) devices.Discussion : MARS and SPAD utilize albumin-based dialysis to remove protein-bound and water-soluble toxins. Prometheus applies a fractionated plasma separation and adsorption approach, while ADVOS enables individualized acid-base correction. Bioartificial liver systems integrate hepatocyte bioreactors with plasma dialysis to provide more physiological metabolic support. While these systems show promise in improving clinical outcomes, long-term survival benefit remains under investigation.Conclusion :  Extracorporeal liver support systems offer essential bridging and supportive therapies for patients with liver failure. Selection should be tailored to patient condition, therapeutic goals, and technology availability.
Co-Authors Akhmad Yun Jufan Bhirowo Yudo Pratomo Calcarina Fitriani Retno Wisudarti Deviatika, Fiandila Elvana Fatmi Eka Putri Juni Kurniawaty Muhdar Abubakar Djayanti Sari