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All Journal Jurnal Komplikasi Anestesi
Gentong, Metia Gledis Gilang
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Medicine & Pharmacology

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Tablet Gabapentin sebagai Analgesia Multimodal Perioperatif dalam Anestesi Umum Widodo, Untung; Sarosa, Pandit; Gentong, Metia Gledis Gilang
Jurnal Komplikasi Anestesi Vol 6 No 2 (2019): Volume 6 Number 2 (2019)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v6i2.7355

Abstract

Multimodal analgesia is a combination of different drugs with different actions and targets in the nervoussystem, producing addictive effects or synergistic analgesia by reducing the side effects of single drug. The response of the humoral and neuronal complexes that occur due to surgery requires balanced perioperative pain management. Multimodal use can reduce the dose of each drug and reduce the incidence of side effects of drugs used for the treatment of perioperative pain, which can shorten hospitalization time, speed-up recovery and function of the body, and reduce health costs. Today, the American Society of Anesthesiologists Task Force on Acute Pain Management advocates the use of multimodal analgesia.
Efikasi Profilaksis Granisetron 40 mcg/kgBB Dibandingkan Ondansetron 8 mg dan Meperidine 0,4 mg/kgBB dalam Mencegah Shivering Paska Anestesi Spinal di RSUP Dr. Sardjito Gentong, Metia Gledis Gilang; Kurniawaty, Juni; Sudadi, Sudadi
Jurnal Komplikasi Anestesi Vol 11 No 3 (2024): Volume 11 Number 3 (2024)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v11i3.13178

Abstract

Background. Spinal anesthesia induced hypothermia resulting in shivering and inducing adverse complications for the patient. Meperidine effectively prevent the incidence of shivering but has many side effects. Granisetron and ondasetron are known to prevent shivering with minimal side effects when working in thermoregulation. Aim. Efficacy of granisetron compared to ondansetron and meperidine in preventing shivering after spinal anesthesia. Method. The study was a double-blind randomized clinical trial of 97 male/female subjects, aged 18-65 years, physical status ASA I and II with emergency or elective surgery in RSUP Dr. Sardjito Yogyakarta. Subjects divided into three groups: Granisetron 40 mcg/kgbw (group G), Ondansetron 8 mg (Group O) and Meperidine 0.4 mg/kgbw (group M). Results. We found shivering in Group G showed 10 subjects (31.3%), group O showed 15 subjects (45.5%) and group M showed 10 subjects (31.3%) (p=0.386). Group G decreased the severity of shivering because grade 3 and 4 did not occur at 60 minutes, better than group O, which showed 5 subjects (15.2%) experiencing grade 3 and 1 subject (5%) experiencing grade 4. (p=0.044). Conclusion. Prophylactic granisetron 40 mcg/kgbw before spinal anesthesia reduces the severity of shivering compared to ondansetron 8 mg. Prophylactic granisetron 40 mcg/kgbw and ondansetron 8 mg reduced the incidence of shivering same as meperidine 0.4 mg/kgbw. Keywords. Shivering, Spinal Anesthesia, Granisetron, Ondansetron, Meperidine.
Co-Authors Juni Kurniawaty Muhdar Abubakar Djayanti Sari Sarosa, Pandit SATRIYAS ILYAS Untung Widodo, Untung