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All Journal Ranah Research : Journal of Multidisciplinary Research and Development Kartika : Jurnal Ilmiah Farmasi
Wulantresna, Dewi
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Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Transportation Other

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MASKER WAJAH DENGAN BAHAN AKTIF EKSTRAK CEMPAKA KUNING Wulantresna, Dewi; Zuhrotun, Ade; Chaerunisaa, Anis Yohana
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 1 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i1.648

Abstract

Sediaan kosmetika masker wajah yang mengandung bahan alami saat ini telah banyak beredar dipasaran, namun belum ada sediaan masker wajah dengan bahan aktif ekstrak bunga cempaka kuning. Adanya aktivitas antioksidan bunga cempaka kuning telah dilaporkan dari ekstrak dengan nilai IC50 5,12 µg/mL dan dari masker gel peel off yang mengandung ektrak bunga dengan nilai persen peredaman sebesar 51,75% mengandung 2 x IC50 (F2)  dan 54,5% mengandung 3 x IC50 (F3). Namun sediaan masker gel tersebut belum diketahui keamanan dan kestabilan fisik sediaannya. Studi literatur ini bertujuan untuk melihat dan mengetahui potensi ekstrak cempaka kuning dalam pengembangan pada sediaan masker wajah dan beberapa pengujian kualitas dan kestabilan sediaan masker wajah. Metode dalam kajian literatur ini adalah pencarian artikel jurnal dan buku yang bersumber dari database PubMed, Sciencedirect dan Google Scholar. Hasil penelusuran pustaka diperoleh 99 artikel dipilih untuk skrining awal. Berdasarkan kajian literatur dapat disimpulkan bahwa ekstrak cempaka dapat memungkinkan untuk dikembangkan menjadi bentuk sediaan masker wajah, baik masker peel off atau sediaan masker lainnya. Kata kunci: Antioksidan, ekstrak bunga cempaka kuning, masker wajah Abstract Face mask as cosmetic preparations containing natural ingredients are currently widely distributed in the market, but there is no face mask preparation with the active ingredient yellow champaka flower extract. Antioxidant activity of yellow champaka flower has been reported from extract with an IC50 value of 5.12 µg/mL and from a peel off gel mask containing this extract with a percent inhibition of 51.75% containing 2xIC50 (F2) and 54.5% containing 3xIC50 (F3). However, this gel mask preparation is not yet known for its safety and physical stability. This literature study aims to know the potential of yellow champaka extract in the development of facial mask preparations and its several quality and stability tests. The method in this literature review is the search for journal articles and books sourced from the PubMed, Sciencedirect and Google Scholar databases. The results of the literature search obtained 99 articles selected for initial screening. Based on the literature review, it can be concluded that champaka extract can allow it to be developed into a face mask dosage form, either a peel off mask or other mask preparations. Keywords: Antioxidant, yellow champaka flower extract, face mask
Transethosomes as Vesicular Drug Delivery : a Modified Form of Ethosomes and Transfersomes Rosmiati, Meiti; Wulantresna, Dewi; Emelia, Rida
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 7 No. 3 (2025): Ranah Research : Journal Of Multidisciplinary Research and Development
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/rrj.v7i3.1432

Abstract

Liposomal vesicle formulations can be classified into two categories, namely rigid hard vesicles such as liposomes and elastic vesicles such as transferosome. One of the shortcomings of conventional liposomes is their permeation strength in the stratum corneum, so that in later generations liposomes are designed to be able to better overcome these obstacles. Deformable liposomes, also known as transfersomes, are liposomes that contain edge activators/surfactants. The combination of phospolipids with membrane softening agents allow the transfersome to penetrate pores that are five times smaller than their own diameter, even after it passes through small pores. Ethosomes are liposomes with modified ethanol that act as reservoir systems and offer the continuous delivery of drugs to the desired site. The high concentration of ethanol content in the manufacture of ethosome systems makes this system different from other vesicle systems, because the ethanol content will interfere with the double layer of skin lipids and thus increase the ability of vesicles to penetrate into the stratum corneum. Phospholipids in ethosomes serve as vesicular-forming components. Phospholipids are also reported to act synergistically with ethanol to improve drug permeation in ethosome formulations. Transethosomes are ethanol-based lipid vesicular systems resulting from modifications of ethosome and transfersome systems that can increase penetration in the skin. It is a new generation of the ethosome system which developed by increasing the flexibility of vesicles by redistributing edge activators and lipids on the skin. The mechanism of action of transethosomes is a combination of advantages of both transferosome systems and ethosomes.
Co-Authors Ade Zuhrotun Anis Yohana Chaerunisaa, Anis Yohana Emelia, Rida Rosmiati, Meiti