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All Journal Equilibrium: Jurnal Pendidikan Journal of Stem Cell Research and Tissue Engineering Jurnal Bastra (Bahasa dan Sastra)
Harmin
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Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Social Sciences Veterinary Other

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LONG-TERM EVALUATION OF THE SAFETY AND EFFECTIVENESS OF NEURAL STEM CELL TRANSPLANTATION FOR CHRONIC THORACIC SPINAL CORD INJURY Harmin; Maharani, Hanisa Aulia
Journal of Stem Cell Research and Tissue Engineering Vol. 9 No. 1 (2025): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v9i1.73556

Abstract

Spinal cord injury (SCI) is a debilitating neurological condition that leads to partial or complete loss of motor and sensory function, depending on the injury’s severity and location. Conventional therapies focus on surgical stabilization, prevention of secondary damage, and rehabilitation. However, these approaches often fall short in restoring long-term functionality. In recent years, cell-based therapies have emerged as promising alternatives, particularly those involving neural stem cells (NSCs). This literature review explores the long-term safety and effectiveness of NSC transplantation for chronic thoracic SCI, based on studies published between 2010 and 2025. Research shows that fetal-derived NSCs, such as HuCNS-SC, demonstrate a high safety profile and low risk of tumor formation due to their committed neural lineage. Clinical trials report early signs of motor improvement and reduced spasticity in chronic SCI patients following transplantation. Additionally, mesenchymal stem cells (MSCs) have shown the ability to migrate to injury sites and exert therapeutic effects, though these benefits tend to be short-lived. The post-injury inflammatory microenvironment poses a significant barrier to the success of NSC therapies by impairing stem cell differentiation and survival. Therefore, immunosuppressive regimens are often employed to enhance NSC efficacy by creating a more supportive environment. Overall, while both NSCs and MSCs offer promising avenues for SCI treatment, long-term recovery likely requires multimodal approaches that address both neural regeneration and immune modulation. Continued research is essential to optimize these therapies and translate them into effective clinical treatments for patients with chronic SCI.
DECODING YAP-DRIVEN MALIGNANT REPROGRAMMING IN ORAL EPITHELIAL STEM CELLS THROUGH SINGLE-CELL ANALYSIS Putri, Indah Salsabila Febriana; Harmin; Maharani, Hanisa Aulia
Journal of Stem Cell Research and Tissue Engineering Vol. 9 No. 1 (2025): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v9i1.73558

Abstract

Oral squamous cell carcinoma (OSCC), a major subtype of head and neck squamous cell carcinoma (HNSC), is characterized by high mortality rates and cellular heterogeneity that complicates early detection and treatment. Recent advances in cancer biology suggest that tumorigenesis involves reprogramming of epithelial progenitor cells into cancer stem-like cells (CSCs), driven by oncogenic signaling such as Yes-associated protein (YAP) activation. YAP, a key effector of the Hippo pathway, regulates transcriptional programs involved in cell proliferation, dedifferentiation, and inhibition of differentiation. However, the specific mechanisms by which YAP reprograms oral epithelial stem cells remain incompletely understood. This literature review systematically explores findings from studies published between 2020 and 2025 that investigate the role of YAP in malignant reprogramming, particularly through single-cell analysis approaches. Articles were sourced from PubMed and Google Scholar using defined inclusion criteria, focusing on original studies involving in vitro, in vivo, or bioinformatic models. The review highlights that YAP activation in oral epithelial cells induces stemness-associated genes (e.g., SOX2, NANOG, OCT4), represses differentiation pathways (Notch, p63), and promotes epithelial-mesenchymal transition (EMT) markers (ZEB1, SNAI2, VIM). Single-cell RNA sequencing (scRNA-seq) has revealed dynamic and hybrid cell states, supporting the view that YAP-driven transformation is gradual and reversible. YAP also shapes the tumor microenvironment by inducing cytokines that recruit tumor-supportive immune and stromal cells. Key YAP-regulated targets such as CTGF, AXL, and ITGA6 emerge as potential therapeutic entry points, as their inhibition reduces proliferation and stemness. These findings underscore YAP’s central role in oral carcinogenesis and its promise as a molecular target for early intervention and therapy.
Padi Berume sebagai Perwujudan Ketahanan Pangan di Desa Pangkal Niur Kabupaten Bangka: Pelestarian Kearifan Lokal di Tengah Terpaan Kerentanan Harmin; Ebin; Ilham Rizki Juliansyah; Herza, Herza
Equilibrium: Jurnal Pendidikan Vol. 13 No. 3 (2025): EQUILIBRIUM: JURNAL PENDIDIKAN
Publisher : Universitas Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/9y6zdt87

Abstract

This study aims to explore in depth the reasons why the majority of the Pangkal Niur Village community maintains the tradition of berume dryland rice farming amid various vulnerabilities, examine the manifestations of the reasons why the Pangkal Niur Village community maintains the tradition of dryland rice farming today, and analyze the local government's response to the vulnerabilities faced by dryland rice farmers. In this study, the researcher used a qualitative research method with a case study approach. Data were obtained through interviews, observations, and documentation, then analyzed using Pierre Bourdieu's social practice theory, which includes the concepts of habitus, capital, and arena. The results of the study show that there are several motives for the persistence of the berume tradition, including: (1) the manifestation of habitus that has become a tradition passed down from generation to generation; (2) the rationality that berume is more economical than paddy fields; (3) berume is a form of local food security; (4) the existence of mutual cooperation and togetherness values that continue to be upheld. In addition, the berume tradition is manifested in: (1) the continued use of traditional subsistence methods amid the modernization of farmers; (2) the use of berume rice in the nisab and memere/ngebaru (ngeberas baru) traditions; (3) intercropping rice fields with 1-3-year-old oil palm trees; (4) preserving forests because they are considered a source of freedom. Furthermore, the government, through the Bangka Food and Agriculture Service, has released local rice varieties and distributed fertilizers and pesticides to field farmers, although it is now more focused on paddy rice because of its higher production.
KEMAMPUAN MENULIS SURAT LAMARAN PEKERJAAN SISWA KELAS XII SMK NEGERI 1 MORAMO Harmin
Jurnal Bastra (Bahasa dan Sastra) Vol. 9 No. 4 (2024): JURNAL BASTRA EDISI OKTOBER 2024
Publisher : Program Studi Pendidikan Bahasa dan Sastra Indonesia, FKIP, Universitas Halu Oleo Kampus Bumi Tridharma Andounohu Kendari, Provinsi Sulawesi Tenggara – Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36709/bastra.v9i4.510

Abstract

Job application letters are very useful information in laying the foundation for understanding Indonesian and at the same time a strong foundation for the formation of students' scientific character. The research problem is "How is the ability of class XII students of SMK Negeri 1 Moramo in writing job application letters?" The purpose of this study is to describe the ability of class XII students of SMK Negeri 1 Moramo in writing job application letters. The instrument used in this study was writing a job application letter with three indicators as a reference, namely the systematic form of the letter, the suitability of the letter with EYD and the effectiveness of the letter sentences. The results of the study can be obtained information that from 35 respondents who were sampled in this study can be classified as follows, 29 respondents (94.28%) obtained the very capable category and 4 respondents (11.43%) obtained the capable category and 2 respondents (5.72%) obtained the less capable category. The highest category is the very capable category, so it can be concluded that the ability of class XII students of Moramo State Vocational School in writing job application letters in three aspects of ability is in the very capable category. It was concluded that on average the ability of class XII students of Moramo 1 State Vocational School in writing job application letters reached 82.31%. The average value is in the range of 65% - 84% with the capable criteria.
Co-Authors Ebin Herza, Herza Ilham Rizki Juliansyah Maharani, Hanisa Aulia Putri, Indah Salsabila Febriana