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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Ibrahimiyah, Nur Aisah
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Health Professions Medicine & Pharmacology

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Polymorphic CAG and GGN repeats in Cryptorchidism patient risk: A meta-analytical study Lutfiana, Nurul Cholifah; Purnomo, Athaya Febriantyo; Ibrahimiyah, Nur Aisah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.22603

Abstract

Genetic mutations in the androgen receptor (AR) gene have been identified as the cause of androgen insensitivity syndrome. These mutations are linked to inconsistent development of the Wolffian duct and may result in conditions such as micropenis, hypospadias, and cryptorchidism. The androgen receptor has two polymorphic sites located in exon 1, which consists of varying amounts of CAG and GGN repeats. These repetitions lead to the formation of polyglutamine and polyglycine stretches of varied lengths. Increased CAG repeats lead to a decrease in androgen receptor transcriptional activity, but the impact of GGN triplets is less well understood. This research examined the CAG and GGN repeat lengths in males who had a past medical record of cryptorchidism. Prospective and retrospective observational studies from PubMed, Science Direct, and Embase were systematically searched up to 15th November 2020. Primary outcomes were analyzed using a fixed or random effect model regarding its heterogeneity and continued with multilevel modeling of each polymorphism and ethnicity. CAG and GGN repeat polymorphism was found to be significantly different compared to control in contributing to cryptorchidism (CAG: 0.55 [CI 95%=0.19-0.91]; p-value=0.003 and GGN 0.90 [CI95%=0.65-1.15]; p value<0.000).  In conclusion, CAG and GGN repeat polymorphism have an essential role in the incidence of cryptorchidism.
Pengaruh Pemberian Minyak Atsiri Aetoxylon sympetalum terhadap Tingkat Ketahanan Fokus Mahasiswa Tahun Pertama Fakultas Kedokteran Primadina, Nova; sari, Nilam; Levani, Yelvi; Ibrahimiyah, Nur Aisah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.23675

Abstract

First-year medical students tend to experience stress, which can affect how they maintain focus on their work. One alternative treatment that can be done is through relaxation techniques using aromatherapy in the form of essential oils. Crocodile agarwood (Aetoxylon sympetalum) is one of the plants that can provide anxiolytic and antidepressant effects that can be associated with these problems. This study aims to determine the effect of giving Aetoxylon sympetalum essential oil on the level of ability to maintain the focus of first-year students of the medical faculty. This quasi-experiment research method with a nonequivalent control group design was conducted on 34 samples which were divided into control and treatment groups with the same number to see the effect of essential oil on both groups. The research data were analyzed using Spearman's rho test and showed a significance value of 0.004 and a correlation coefficient value of 0.661, meaning that a significant correlation was obtained, the level of correlation between variables was strong and unidirectional. So it can be concluded that the more often inhaling Aetoxylon sympetalum essential oil, the ability to maintain focus will increase.
Co-Authors Lutfiana, Nurul Cholifah Nilam Sari Nova Primadina Purnomo, Athaya Febriantyo Yelvi Levani