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All Journal Parapemikir Jurnal Ilmiah Farmasi Jurnal Sains dan Kesehatan
Dewi, Yulisa Raras
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics

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Efektivitas Sun Protecting Factor Serum Ekstrak Biji Pinang (Areca catechu L.) Sebagai Tabir Surya Sawitri, Satwika Budi; Dewi, Yulisa Raras; Suciati, Anugerah; Agustin, Brillian Sindi
Parapemikir : Jurnal Ilmiah Farmasi Vol 14, No 2 (2025): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v14i2.8613

Abstract

The impact of UV exposure on the skin is to increase the risk of skin cancer, cause sunburn, accelerate premature aging, dark spots and various other skin problems. Based on various research data on the activity of areca nut extract, it can support the development of herbal ingredients for the pharmaceutical and cosmetic industries. The purpose of this study was to determine the effectiveness of areca nut extract serum preparations as sunscreen by calculating the SPF value. The research method used was an experimental method in the laboratory by varying the concentration of areca nut extract in the serum preparation at F0 0%; F1 1.5%; F2 3%; F3 4.5% and F4 6%. The results showed that the extract serum with organoleptic brick red preparations, the distinctive aroma of areca nuts and a semi-solid texture. The resulting pH value ranged from 5.10 to 5.63 with a spreadability of the preparation between 5.13 to 6.07 cm and a viscosity of the preparation in the range of 1363.03 to 4703.03 cPs. The test results on the SPF value showed that F4 had the highest SPF value of 7.088 which was included in the maximum protection category. Based on this study, it can be concluded that the areca nut extract serum in the Oneway Anova test obtained a significance value of 0.05, meaning that there was no significant difference in the SPF activity of each sample. So it can be concluded that the difference in the concentration of areca nut extract in the serum formulation does not significantly affect the sun protecting factor value in the areca nut extract serum preparation.
Potensi Antidiabetes Fraksi N-Heksana, Fraksi Metanol, dan Ekstrak Etanol Jahe Merah (Zingiber officinale var. Rubrum) terhadap Penghambatan Enzim Alfa-Amylase: Antidiabetic Potential of N-Hexane Fraction, Methanol Fraction, and Ethanol Extract of Red Ginger (Zingiber officinale var. Rubrum) Towards Inhibiting the Alpha-Amylase Enzyme Rabbaniyyah, Muthi'ah; Dewi, Yulisa Raras; Hasanah, Fauziyyah Al; Fadhilah, Shobiyyah Hasna; Aisyah, Siti Norli
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2307

Abstract

Red ginger is one of the natural ingredients that can be used to treat diabetes mellitus instead of synthetic drugs, which can have too many side effects. The compounds gingerol and shogaol obtained from red ginger have the ability to inhibit the alpha-amylase enzyme's function. Red ginger extract employs a liquid-liquid extraction method with a separating funnel for methanol fractionation and n-hexane fractionation, using a 96% ethanol solvent with an extraction method. The TLC method is utilized to identify the compounds of gingerol and shogaol, and UV-Vis spectrophotometry is employed to measure the inhibition of alpha-amylase enzyme activity. Utilizing the Rf value computation and the IC50 value computation results, data analysis was performed. The result of the methanol fraction of  5,585 µg/ml had the highest IC50 value followed by ethanol extract of 5,778 µg/ml and finally the n-hexane fraction of  5,783 µg/ml.   Keywords:          Fraction, extract, red ginger, inhibition, alpha-amylase enzyme   Abstrak Isi abstrak Pengobatan diabetes melitus dapat menggunakan bahan alam yaitu dengan jahe merah agar dapat mengurangi penggunaan obat-obatan sintesis yang dapat memicu terjadinya efek samping yang berlebih. Jahe merah memiki kandungan senyawa gingerol dan shogaol yang dapat melakukan penghambatan pada aktivitas enzim alfa-amilase. Ekstrak jahe merah menggunakan pelarut etanol 96% dengan metode maserasi, untuk fraksinasi n-heksana dan fraksinasi methanol menggunakan metode ekstraksi cair-cair yang menggunakan corong pisah. Identifikasi senyawa gingerol dan shogaol menggunakan metode KLT untuk uji penghambatan aktivitas enzim alfa-amilase menggunakan spektrofotometri UV-Vis. Analisis data dilakukan dengan menggunakan perhitungan nilai Rf dan hasil perhitungan nilai IC50. Adapun nilai IC50 tertinggi yaitu pada hasil fraksi  metanol sebesar 5.585 µg/ml diikuti dengan ekstrak etanol 5.778 µg/ml dan terakhir fraksi n-heksana sebesar 5.783 µg/ml.   Kata Kunci:         Fraksi, ekstrak, jahe merah, penghambatan, alfa-amylase
Co-Authors Agustin, Brillian Sindi Aisyah, Siti Norli Anugerah Suciati Fadhilah, Shobiyyah Hasna Hasanah, Fauziyyah Al Rabbaniyyah, Muthi'ah Sawitri, Satwika Budi