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All Journal JPBIO (Jurnal Pendidikan Biologi) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal MedScientiae
Sudrajat, Susana Elya
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Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effect of The Addition of Lime (Citrus aurantifolia) on Total Phenolic and Antioxidant of Turmeric Infusion (Curcuma domestica Val.) Rukmana, Dewi Samudra Putri Aliffa; Rumiati, Flora; Sudrajat, Susana Elya
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3459

Abstract

Turmeric is a traditional drink that has been known since ancient times in Indonesia. Turmeric is an herbal ingredient that is efficacious as an antioxidant and is usually combined with tamarind. The added tamarind serves to add to the efficacy of turmeric. In this study, the role of tamarind from sour turmeric drink was replaced with lime fruit. The purpose of this study was to determine the effect of lime powder on pH, antioxidant activity and total phenol of turmeric infusion. Lime turmeric infusion is made by adding water at 900C for 15 minutes. The lime turmeric infusion solution was then tested for pH, total phenol, and antioxidant levels using the DPPH method. Turmeric infusion without the addition of lime fruit powder has a pH of 4.8, total phenol content of 1.324 ± 0.013 mgGAE/g, and antioxidant of 312.55 ± 0.62 ppm. While the turmeric infusion with the addition of lime has a pH of 3.4, a total phenol content of 1.852 ± 0.004 mgGAE/g, and an antioxidant value of 31.80 ± 1.22 ppm. The addition of lime fruit to turmeric infusion resulted in a decrease in pH, an increase in total phenol levels, and antioxidant levels.
The Phytochemical constituents and biological activities of sungkai (Peronema canescens Jack) leaves hydroethanolic extracts Rahayu, Ika; Sudrajat, Susana Elya; Sancnia, Sancnia; Puspasari, Monica; Timotius, Kris Herawan
JPBIO (Jurnal Pendidikan Biologi) Vol 9, No 1 (2024): April 2024
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v9i1.3398

Abstract

Peronema canescens, Jack commonly known as "sungkai," has been traditionally used as a herbal medicine for various health conditions. This study aimed to explore the bioactive compound of the P. canescens leaves hydroethanolic extract, along with assessing its antioxidant and antimutagenic properties. Liquid chromatography-mass spectrometry (LC-MS) was utilized for phytochemical analysis of the hydroethanolic extracts, while antioxidant activity was evaluated through the DPPH radical scavenging method. Quantification of total phenolic and flavonoid content was achieved via colorimetric analysis. Furthermore, the DNA protection activity was assessed using plasmid pBR322 subjected to free radical treatment. The primary bioactive compounds identified in the P. canescens hydroethanolic extracts belonged to the alkaloid and flavonoid groups. The antioxidant activity of P.canescens leaves hydroethanolic extracts showed an IC50 value of 0.02±0.00 µg/mL. Additionally, the total flavonoid and phenolic content were measured at 33,769±3,626 µg QE/mL and 638,924±6,683 µg GAE/mL, respectively. Notably, P.canescens exhibited significant potential in mitigating DNA damage. In conclusion, the P. canescens leaves hydroethanolic extracts demonstrate promising attributes as a herbal medicine, highlighting notable antioxidant and antimutagenic effects.
In silico study of the bioactive compounds in Peronema canescens Jack (Sungkai) leaf infusion targeting VEGFR-2: Insights into anticancer potential rahayu, Ika; Sudrajat, Susana Elya; Timotius, Kris Herawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art6

Abstract

Background: Peronema canescens Jack, commonly known as sungkai, is a medicinal plant traditionally consumed as a herbal infusion. It has demonstrated potential anticancer properties attributed to its bioactive constituents, particularly clerodane-type diterpenoids known as peronemins. The anticancer potential of these compounds can be preliminarily explored using in silico approaches. Of particular interest are the reported the cytotoxic effects of sungkai leaves against cancer cell lines and their interactions with angiogenesis-related targets, including vascular endothelial growth factor receptor-2 (VEGFR-2). VEGFR-2 is a critical tyrosine kinase receptor that regulates angiogenesisa and Its aberrant activation contributes to tumor growth and metastasis. Consequently, VEGFR-2 represents a well-established target for anticancer therapy development. Objectives: This study aims to investigate the bioactive compounds present in sungkai leaf infusion using liquid chromatography-mass spectrometry (LC-MS), and to predict their interactions with VEGFR-2 through in silico molecular docking analysis. Methods: Phytochemical profiling of the leaf infusion was conducted using LC-MS. Molecular docking was performed using PyRx 0.8 integrated with AutoDock Vina to assess ligand-protein interactions between selected compounds and VEGFR-2 (PDB ID: 2QU5). The resulting interactions were visualized using Discovery Studio.Results: LC-MS analysis identified ten major compounds in the leaf infusion, consisting of one alkaloid (gentiatibetine) and nine flavonoids. Molecular docking analysis revealed that genkwanin and acacetin-7-galactoside exhibited strong binding affinities toward VEGFR-2 (−9.6 and −9.2 kcal/mol, respectively), approaching that of the referencesorafenib (−11.2 kcal/mol). Both compounds interacted with key catalytic residues, suggesting their potential to inhibit VEGFR-2 by stabilizing its inactive conformation.Conclusion: This study provides the first to report that sungkai leaf infusion is rich in flavonoid compounds two of which exhibit strong anti-VEGFR-2 activity. These findings suggest the potential of sungkai leaf infusion as a natural anticancer agent and support the needfor further in vitro and in vivo validation.
Tinjauan Pustaka: Potensi Aktivitas Antioksidan Spirulina sp Terhadap Penyakit-penyakit Metabolik dan Proses Degeneratif Patadan, Arya; Rumawas, Marina Astrid; Sudrajat, Susana Elya
Jurnal MedScientiae Vol 2 No 3 (2023): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2978

Abstract

Free radicals are normal metabolites in the form of molecules of one or more unpaired electrons, so they are highly reactive and can cause cell damage and disrupt homeostasis. Depletion of antioxidants or accumulation of free radicals can cause oxidative stress, which plays a role in various disease processes such as inflammation, cancer, hemochromatosis, emphysema, high blood pressure to the aging process. Spirulina platensis is also known as blue-green filamentous algae because it is a colony-forming blue-green autotroph where columnar cells are arranged in columns to form twisted filaments resembling helices. C-Phycocyanin is one of the major groups of water-soluble and widely distributed phycobiliprotein in spirulina. The purpose of writing this literature review is to determine the potential antioxidant activity of Spirulina platensis against metabolic diseases and degenerative processes. This writing is in the form of a literature study by searching for data using two databases, Pudmed and Google Scholar. The keywords used are, Spirulina platensis, antioxidant activity, metabolic and degenerative diseases. After being selected based on inclusion and exclusion criteria, 21 references were obtained for review. Spirulina platensis has shown antioxidant, antidiabetic and antihypertensive effects in vitro and in vivo.
Co-Authors Anggreni, Dewi Flora Rumiati Harahap, Elisabeth Dasmareta Ika Rahayu Kris Herawan Timotius Patadan, Arya Puspasari, Monica Renjaan, Maria Rukmana, Dewi Samudra Putri Aliffa Rumawas, Marina Astrid Sancnia, Sancnia