Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Bioscientist : Jurnal Ilmiah Biologi
Khoirunnisa Sidabutar
Universitas Islam Negeri Sumatera Utara
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Social Sciences

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Potential Effects of Gandaria (Bouea macrophylla Griff.) Fruit Ethanol Extract on IL-6 Gene Expression in the Brain of Carbon Tetrachloride (CCl₄)-Induced White Rats (Rattus norvegicus L.) Khoirunnisa Sidabutar; Zahratul Idami; Leni Widiarti; Nurlian Augustin Ningrum
Bioscientist : Jurnal Ilmiah Biologi Vol. 14 No. 3 (2026): September
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v14i3.21417

Abstract

This study aimed to evaluate the effect of gandaria fruit ethanol extract on IL-6 expression in the brain tissue of CCl₄-induced rats. A completely randomized experimental design was employed using 20 male white rats (Rattus norvegicus L.), which were assigned to five groups: normal control (KN), positive control (K+), treatment group 1 (P1) receiving 100 mg/kgBW of gandaria fruit ethanol extract, treatment group 2 (P2) receiving 150 mg/kgBW, and treatment group 3 (P3) receiving 200 mg/kgBW. IL-6 gene expression in brain tissue was analyzed using reverse transcription polymerase chain reaction (RT-PCR), followed by band intensity and relative density analyses. The relative density analysis revealed that the greatest reduction in IL-6 gene expression occurred in the P1 treatment group administered 100 mg/kgBW of gandaria fruit ethanol extract, with a fold change value of 2.5. These findings suggest that gandaria fruit ethanol extract may attenuate the inflammatory response induced by CCl₄ exposure through the suppression of IL-6 expression, with the 100 mg/kgBW dose exhibiting the most pronounced reduction based on relative density analysis.
Co-Authors Leni Widiarti Nurlian Augustin Ningrum Zahratul Idami