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Formulation And Physical Characteristic Of Hard Candy Lozenge Of Citrus Limon Essential Oil On Various Types Of Sugar Free Candy Base (Isomalt, Mannitol, Sorbitol) Nawatila, Roisah; Azminah
Pharmaceutical Journal of Indonesia Vol. 10 No. 1 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.010.01.8

Abstract

Citrus limon is a natural ingredient that has potential as an anti-anxiety. The effect of increasing dopamine on the brain barrier due to consuming citrus limon essential oil can help relieve stress, fatigue, dizziness, and anxiety. This study aims to formulate citrus limon essential oil hard candy lozenge with various types of sugar free candy bases and evaluate its effect on the physical characteristic of the lozenge. Previously, this study was preceded by identifying the D-Limonene compounds as an active material on the citrus limon essential oil using the GC-MS method. There are three formulas used in this study, including F1 (isomalt), F2 (mannitol), and F3 (sorbitol). Physical characteristic tests carried out include organoleptics, weight variations, dimension, hardness, friability, dissolved pH, dissolve time, and hedonic tests. The identification test of citrus limon essential oil showed the presence of D-Limonene compound, in accordance with CoA and comparative literature. Thus, it can be concluded that the raw material of the oil used in this study was in accordance with the established quality. In addition, the results of physical characteristic showed that the organoleptic test of F1 and F3 yields better results than F2 (murky white color and rough texture). In addition, the evaluation of weight variation, friability, and dissolve time of F1 and F3 met specifications, while F2 did not meet specifications. Therefore, the sugar free candy base that can be developed into a hard candy lozenge in this study was by using isomalt (F1) and sorbitol (F3).
Formulation And Physical Characteristic Of Hard Candy Lozenge Of Citrus Limon Essential Oil On Various Types Of Sugar Free Candy Base (Isomalt, Mannitol, Sorbitol) Nawatila, Roisah; Azminah
Pharmaceutical Journal of Indonesia Vol. 10 No. 1 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.010.01.8

Abstract

Citrus limon is a natural ingredient that has potential as an anti-anxiety. The effect of increasing dopamine on the brain barrier due to consuming citrus limon essential oil can help relieve stress, fatigue, dizziness, and anxiety. This study aims to formulate citrus limon essential oil hard candy lozenge with various types of sugar free candy bases and evaluate its effect on the physical characteristic of the lozenge. Previously, this study was preceded by identifying the D-Limonene compounds as an active material on the citrus limon essential oil using the GC-MS method. There are three formulas used in this study, including F1 (isomalt), F2 (mannitol), and F3 (sorbitol). Physical characteristic tests carried out include organoleptics, weight variations, dimension, hardness, friability, dissolved pH, dissolve time, and hedonic tests. The identification test of citrus limon essential oil showed the presence of D-Limonene compound, in accordance with CoA and comparative literature. Thus, it can be concluded that the raw material of the oil used in this study was in accordance with the established quality. In addition, the results of physical characteristic showed that the organoleptic test of F1 and F3 yields better results than F2 (murky white color and rough texture). In addition, the evaluation of weight variation, friability, and dissolve time of F1 and F3 met specifications, while F2 did not meet specifications. Therefore, the sugar free candy base that can be developed into a hard candy lozenge in this study was by using isomalt (F1) and sorbitol (F3).
STRATEGY FOR IMPROVING LEMONGRASS AGRICULTURE BASED ON SMART FARMING IN JATIJEJER VILLAGE Gondokesumo, Marisca Evalina; Azminah; Ardiansyahmiraja, Bobby; Suryaningsih, Retna
Jurnal Pemberdayaan Masyarakat Madani (JPMM) Vol. 9 No. 1 (2025): Jurnal Pemberdayaan Masyarakat Madani (JPMM) (DOAJ & SINTA 4 Indexed)

Publisher : Fakultas Ekonomi dan Bisnis Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JPMM.009.1.01

Abstract

Lemongrass (Cymbopogon citratus) and citronella (Cymbopogon nardus L.) are flagship crops cultivated by farmers in Jatijejer Village. Lemongrass is commonly used as a culinary spice, while citronella is widely utilized for producing essential oil rich in citronellal, geraniol, and citronellol. The essential oil from citronella has high economic value due to its applications in the cosmetics and health industries. This community service activity aims to enhance local farmers' understanding and skills in proper lemongrass cultivation and the potential processing of essential oils as value-added products. The program focuses on strategies to optimize agricultural potential using proper cultivation techniques with organic farming systems based on smart farming technology. Farmers were educated on the stages of lemongrass cultivation, including land preparation, planting, crop maintenance, fertilization, pest and disease control, as well as harvesting and post-harvest handling. Participants were given pre-tests and post-tests to assess their understanding. The test results showed a significant improvement in participants' comprehension of proper lemongrass cultivation using smart farming methods, as well as the benefits and processing of essential oils. This activity successfully raised awareness of the importance of innovation in the agricultural sector and laid the foundation for the development of local businesses based on natural resources.
PREDIKSI ADMET DAN MOLECULAR DOCKING METABOLIT SEKUNDER CENTELLA ASIATICA SEBAGAI CALON ANTIKANKER PAYUDARA Fadhilah Faza, Farah; Kesuma, Dini; Azminah
Pharmacoscript Vol. 7 No. 1 (2024): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v7i1.1413

Abstract

Kanker payudara merupakan penyakit yang ditandai oleh pembelahan sel payudara yang tidak terkendali, karena mutasi atau perubahan abnormal. Doxorubicin adalah agen kemoterapi standart untuk kanker payudara, namun memiliki efek samping dan dapat menyebabkan resistensi obat. Pemanfaatan bahan alam Indonesia dapat digunakan sebagai sarana pengobatan alternatif/komplementer, dengan keunggulan efek samping relatif kecil dibanding bahan kimia sintetis. Centella asiatica adalah salah satu tanaman yang dapat dimanfaatkan untuk pengobatan tradisional antikanker. Dalam pengembangan dan penemuan obat baru membutuhkan biaya yang besar, waktu yang lama serta tenaga yang banyak karena perlu dilakukan uji coba dan sintesis pada sebagian besar prosesnya tanpa adanya desain atau alasan yang jelas. Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik metabolit sekunder Centella asiatica, secara in silico. Pengujian yang dilakukan adalah prediksi sifat fisikokimia druglikeness, ADME-Tox, serta molecular docking metabolit sekunder dan obat pembanding Doxorubicin terhadap target reseptor SIRT1 (kode PBD: 4I5I.pdb) mengguankan program Autodock Vina. Dengan hasil energi ikatan yang lebih baik daripada obat pembanding Doxorubicin (-9,46kkal/mol), yaitu 3-O-cis-Caffeoylquercetin (-10.34kkal/mol), Quercetin (-10.28kkal/mol), dan 3-O-cis-Coumaroyl-kaempferol (-10.19kkal/mol). Maka metabolit sekunder Centella asiatica terbaik secara in sillico, yang dapat digunakan sebagai calon antikanker payudara adalah 3-O-cis-Caffeoylquercetin.
Optimization of the Separation and Validation Method for Ginsenoside Re and Ginsenoside Rg1 Compounds in Panax Ginseng Powder Extract Using the HPLC Method: A Systematic Literature Review Rossardy, Marzella Dea; Azminah
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.7665

Abstract

The analytical methods used to analyze ginsenoside compounds include TLC, HPTLC, HPLC, UPLC, GC and MS. The HPLC method is the most widely used analytical technique with various combinations of UV detection or with ELSD. The HPLC method is a method of separating and purifying chemical compounds or medicinal compounds. To study new information from optimization for the separation of ginsenoside Re and ginsenoside Rg1 compounds, then validate the analytical method to show that the method provides accurate results in accordance with the requirements. The data and information used in this review article come from national and international journals. The data and information search method was carried out using the literature research method. keywords: "Optimization of Separation and Method Validation of Ginsenoside Compounds using the HPLC method" with a journal publication period 2019-2023. Of the 35 research articles found, only 9 journals met the inclusion and exclusion criteria. Studies on ginsenoside compounds Re and Rg1 in ginseng plants are still not well separated. So it’s still necessary to optimize the analytical method using the HPLC method and then validate the analytical method to show that the method provides accurate results in accordance with the requirements.