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All Journal Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi Indonesia
Nawatila, Roisah
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pemanfaatan Pati Sagu Pregelatinasi Taut Silang Fosfat sebagai Matriks Tablet Lepas Lambat Natrium Diklofenak Nawatila, Roisah; Wati, Annisa Mahdia; Varasvasti, Jyestha; Aulia, Frea Widia; Avanti, Christina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 1 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.182

Abstract

Sediaan lepas lambat merupakan sediaan yang dirancang agar bahan aktif dapat mencapai pelepasan obat secara perlahan dalam jangka waktu yang lama. Natrium diklofenak memiliki waktu paruh biologis yang relatif singkat (1- 2 jam) sehingga dapat diformulasikan ke dalam bentuk sediaan tablet lepas lambat. Pati sagu memiliki potensi untuk dapat dikembangkan menjadi matriks tablet lepas lambat. Tujuan penelitian ini untuk memanfaatkan pati sagu yang sebelumnya telah dimodifikasi dengan teknik pregelatinasi dan ditaut silang fosfat (PSTF) agar dapat dikembangkan menjadi matriks tablet lepas lambat natrium diklofenak. Pada penelitian ini dibuat PSTF pada konsentrasi 20% (F2), 22,5% (F3), 25% (F4), 27,5% (F5), 30% (F6), dan 32,5% (F7). Selain itu, matriks hidrofilik sintetik yang dapat digunakan dalam sediaan lepas lambat lainnya adalah Hydroxypropyl Methylcellulose (HPMC) dengan konsentrasi 20% sebagai pembanding (F1). Proses pembuatan tablet menggunakan metode granulasi basah. Sediaan tablet yang sudah dibuat selanjutnya dilakukan pengujian mutu fisik dan pengujian pelepasan obat pada jam ke-1, 2, 3, 4, 5, 6, 7, 8, 9, dan 10. Hasil pengujian mutu fisik tablet menunjukkan bahwa semua formula telah memenuhi spesifikasi, walaupun F1 memiliki kekerasan tablet yang paling rendah (4,15 Kp+0,63). Hasil uji disolusi F1 menunjukkan bahwa 3,05% obat dilepaskan selama 1 jam, sedangkan 54,70% obat dilepaskan selama 5 jam, dan sisanya 45% obat dilepaskan dalam sisa 6 jam berikutnya. Hasil uji disolusi F2-F7 pada jam ke-1 berturut-turut melepaskan obat sebesar 89,69%; 56,01%; 85,96%; 65,67%; 68,71%; 85,73%. Hal ini dapat disimpulkan bahwa matriks PSTF belum bisa memberikan pola pelepasan obat yang lambat.
Formulation And Physical Characteristic Of Hard Candy Lozenge Of Citrus Limon Essential Oil On Various Types Of Sugar Free Candy Base (Isomalt, Mannitol, Sorbitol) Nawatila, Roisah; Azminah
Pharmaceutical Journal of Indonesia Vol. 10 No. 1 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.010.01.8

Abstract

Citrus limon is a natural ingredient that has potential as an anti-anxiety. The effect of increasing dopamine on the brain barrier due to consuming citrus limon essential oil can help relieve stress, fatigue, dizziness, and anxiety. This study aims to formulate citrus limon essential oil hard candy lozenge with various types of sugar free candy bases and evaluate its effect on the physical characteristic of the lozenge. Previously, this study was preceded by identifying the D-Limonene compounds as an active material on the citrus limon essential oil using the GC-MS method. There are three formulas used in this study, including F1 (isomalt), F2 (mannitol), and F3 (sorbitol). Physical characteristic tests carried out include organoleptics, weight variations, dimension, hardness, friability, dissolved pH, dissolve time, and hedonic tests. The identification test of citrus limon essential oil showed the presence of D-Limonene compound, in accordance with CoA and comparative literature. Thus, it can be concluded that the raw material of the oil used in this study was in accordance with the established quality. In addition, the results of physical characteristic showed that the organoleptic test of F1 and F3 yields better results than F2 (murky white color and rough texture). In addition, the evaluation of weight variation, friability, and dissolve time of F1 and F3 met specifications, while F2 did not meet specifications. Therefore, the sugar free candy base that can be developed into a hard candy lozenge in this study was by using isomalt (F1) and sorbitol (F3).
Formulation And Physical Characteristic Of Hard Candy Lozenge Of Citrus Limon Essential Oil On Various Types Of Sugar Free Candy Base (Isomalt, Mannitol, Sorbitol) Nawatila, Roisah; Azminah
Pharmaceutical Journal of Indonesia Vol. 10 No. 1 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.010.01.8

Abstract

Citrus limon is a natural ingredient that has potential as an anti-anxiety. The effect of increasing dopamine on the brain barrier due to consuming citrus limon essential oil can help relieve stress, fatigue, dizziness, and anxiety. This study aims to formulate citrus limon essential oil hard candy lozenge with various types of sugar free candy bases and evaluate its effect on the physical characteristic of the lozenge. Previously, this study was preceded by identifying the D-Limonene compounds as an active material on the citrus limon essential oil using the GC-MS method. There are three formulas used in this study, including F1 (isomalt), F2 (mannitol), and F3 (sorbitol). Physical characteristic tests carried out include organoleptics, weight variations, dimension, hardness, friability, dissolved pH, dissolve time, and hedonic tests. The identification test of citrus limon essential oil showed the presence of D-Limonene compound, in accordance with CoA and comparative literature. Thus, it can be concluded that the raw material of the oil used in this study was in accordance with the established quality. In addition, the results of physical characteristic showed that the organoleptic test of F1 and F3 yields better results than F2 (murky white color and rough texture). In addition, the evaluation of weight variation, friability, and dissolve time of F1 and F3 met specifications, while F2 did not meet specifications. Therefore, the sugar free candy base that can be developed into a hard candy lozenge in this study was by using isomalt (F1) and sorbitol (F3).
Co-Authors Aulia, Frea Widia Avanti, Christina Azminah Varasvasti, Jyestha Wati, Annisa Mahdia