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All Journal Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi Indonesia
Nawatila, Roisah
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pemanfaatan Pati Sagu Pregelatinasi Taut Silang Fosfat sebagai Matriks Tablet Lepas Lambat Natrium Diklofenak Nawatila, Roisah; Wati, Annisa Mahdia; Varasvasti, Jyestha; Aulia, Frea Widia; Avanti, Christina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 16 No 1 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.182

Abstract

Sustained release tablets include any drug delivery system that achieves slow release of drug over an extended period. Diclofenac sodium has a relatively short biological half-life (1-2 hours), it can be formulated into a sustained release tablet. Sago starch has the potential to be developed as a matrix for sustained release tablets. The aim of this study was to utilize sago starch which has been modified using pregelatinizing and phosphate cross linked techniques (PSTF), to be developed into a diclofenac sodium sustained release matrix. In this study, PSTF was prepared at concentration of 20% (F2); 22,5% (F3); 25% (F4); 27,5% (F5); 30% (F6); 32,5% (F7). In addition, HPMC as a synthetic hydrophilic matrix was used as reference formula (F1) at 20%. The method used in this study was wet granulation. Tablets that were produced were then tested for physical quality and drug release (at 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 hours). The results of the physical quality tablet showed that all formulas met specifications, although F1 had the lowest hardness (4,15 Kp+0,63). The results of drug release profile of F1 showed that 3,05% of drug was released during first 1 hours, while 54,07% drug was released within initial 5 hours, and the remaining 45% of the drug was released in remaining 5 hours. In addition, the drug release of F2-F7 at the 1 hours was 89,69%; 56,01%; 85,96%; 65,67%; 68,71%; 85,73%, respectively. It can be concluded that PSTF has not provided a sustained release pattern of drug.
Formulation And Physical Characteristic Of Hard Candy Lozenge Of Citrus Limon Essential Oil On Various Types Of Sugar Free Candy Base (Isomalt, Mannitol, Sorbitol) Nawatila, Roisah; Azminah
Pharmaceutical Journal of Indonesia Vol. 10 No. 1 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.010.01.8

Abstract

Citrus limon is a natural ingredient that has potential as an anti-anxiety. The effect of increasing dopamine on the brain barrier due to consuming citrus limon essential oil can help relieve stress, fatigue, dizziness, and anxiety. This study aims to formulate citrus limon essential oil hard candy lozenge with various types of sugar free candy bases and evaluate its effect on the physical characteristic of the lozenge. Previously, this study was preceded by identifying the D-Limonene compounds as an active material on the citrus limon essential oil using the GC-MS method. There are three formulas used in this study, including F1 (isomalt), F2 (mannitol), and F3 (sorbitol). Physical characteristic tests carried out include organoleptics, weight variations, dimension, hardness, friability, dissolved pH, dissolve time, and hedonic tests. The identification test of citrus limon essential oil showed the presence of D-Limonene compound, in accordance with CoA and comparative literature. Thus, it can be concluded that the raw material of the oil used in this study was in accordance with the established quality. In addition, the results of physical characteristic showed that the organoleptic test of F1 and F3 yields better results than F2 (murky white color and rough texture). In addition, the evaluation of weight variation, friability, and dissolve time of F1 and F3 met specifications, while F2 did not meet specifications. Therefore, the sugar free candy base that can be developed into a hard candy lozenge in this study was by using isomalt (F1) and sorbitol (F3).
Formulation And Physical Characteristic Of Hard Candy Lozenge Of Citrus Limon Essential Oil On Various Types Of Sugar Free Candy Base (Isomalt, Mannitol, Sorbitol) Nawatila, Roisah; Azminah
Pharmaceutical Journal of Indonesia Vol. 10 No. 1 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.010.01.8

Abstract

Citrus limon is a natural ingredient that has potential as an anti-anxiety. The effect of increasing dopamine on the brain barrier due to consuming citrus limon essential oil can help relieve stress, fatigue, dizziness, and anxiety. This study aims to formulate citrus limon essential oil hard candy lozenge with various types of sugar free candy bases and evaluate its effect on the physical characteristic of the lozenge. Previously, this study was preceded by identifying the D-Limonene compounds as an active material on the citrus limon essential oil using the GC-MS method. There are three formulas used in this study, including F1 (isomalt), F2 (mannitol), and F3 (sorbitol). Physical characteristic tests carried out include organoleptics, weight variations, dimension, hardness, friability, dissolved pH, dissolve time, and hedonic tests. The identification test of citrus limon essential oil showed the presence of D-Limonene compound, in accordance with CoA and comparative literature. Thus, it can be concluded that the raw material of the oil used in this study was in accordance with the established quality. In addition, the results of physical characteristic showed that the organoleptic test of F1 and F3 yields better results than F2 (murky white color and rough texture). In addition, the evaluation of weight variation, friability, and dissolve time of F1 and F3 met specifications, while F2 did not meet specifications. Therefore, the sugar free candy base that can be developed into a hard candy lozenge in this study was by using isomalt (F1) and sorbitol (F3).
Co-Authors Aulia, Frea Widia Avanti, Christina Azminah Varasvasti, Jyestha Wati, Annisa Mahdia