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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Ners Journal of Pharmaceutical and Sciences.
Rossardy, Marzella Dea
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Optimization of the Separation and Validation Method for Ginsenoside Re and Ginsenoside Rg1 Compounds in Panax Ginseng Powder Extract Using the HPLC Method: A Systematic Literature Review Rossardy, Marzella Dea; Azminah
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.7665

Abstract

The analytical methods used to analyze ginsenoside compounds include TLC, HPTLC, HPLC, UPLC, GC and MS. The HPLC method is the most widely used analytical technique with various combinations of UV detection or with ELSD. The HPLC method is a method of separating and purifying chemical compounds or medicinal compounds. To study new information from optimization for the separation of ginsenoside Re and ginsenoside Rg1 compounds, then validate the analytical method to show that the method provides accurate results in accordance with the requirements. The data and information used in this review article come from national and international journals. The data and information search method was carried out using the literature research method. keywords: "Optimization of Separation and Method Validation of Ginsenoside Compounds using the HPLC method" with a journal publication period 2019-2023. Of the 35 research articles found, only 9 journals met the inclusion and exclusion criteria. Studies on ginsenoside compounds Re and Rg1 in ginseng plants are still not well separated. So it’s still necessary to optimize the analytical method using the HPLC method and then validate the analytical method to show that the method provides accurate results in accordance with the requirements.
Studi Fitokimia Senyawa Aktif Ekstrak Batang Nelambo suon (Rubiaceae) Rossardy, Marzella Dea; Muslihin, A.M.; Watora, Wahyuni; Budiyanto, Angga Bayu; Hardia, Lukman; Irwandi, Irwandi; Aponno, Alyssa Mileta; Utami, Hikmahtul Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1333

Abstract

Background: Papua has high biodiversity with significant potential as a source of traditional medicinal plants, including Nelambo suon (Rubiaceae), which has been empirically used by local communities. However, scientific information regarding the active compounds in its stem bark remains limited. Objective: This study aimed to identify the secondary metabolite groups present in the ethanol extract of Nelambo suon stem bark through phytochemical screening. Methods: The research was conducted experimentally using the maceration method with 80% ethanol as the solvent. The stem bark simplicia was extracted and qualitatively screened for alkaloids, flavonoids, tannins, and saponins using specific reagents. Results: The results showed that the ethanol extract of Nelambo suon stem bark contained alkaloids, flavonoids, tannins, and saponins, indicated by characteristic color changes, precipitate formation, and foam production. Conclusion: These findings suggest that Nelambo suon stem bark is a potential source of bioactive compounds and may be further developed as a herbal medicinal material based on local wisdom.
Efficacy of Akway (Drymis sp.) Bark Extract in Restoring Hemoglobin Levels: A Preclinical Study in a Sodium Nitrite-Induced Anemia Mice Model Lukman Hardia; Fabanyo, Syahrul H.; Budiyanto, Angga Bayu; Muslihin, A. M.; Rossardy, Marzella Dea; Irwandi, Irwandi; Watora, Wahyuni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44062

Abstract

The high prevalence of anemia prompted us to explore the potential of local herbs in Papua, Indonesia, which is known for its rich natural resources. In this study, we aim to conduct preclinical tests on anemia model test animals to validate the effectiveness of akway bark extract (ABE) as the basis for the development of effective and safe herbal antianemia drugs in the future. This study employs a quantitative analytical approach, utilizing an experimental design with a pre-posttest with a control group design. The research sample used 20 mice test animals, divided into 5 groups consisting of 4 animals each, namely: the control group (positive and negative), and the intervention group using ABE doses of 10, 30, and 50mg/kg. This study was approved by the Health Research Ethics Committee of STIFAR Makassar (Number: 299/EC.1.1.B/III/KEPK/2024). Data analysis showed that a 14-day intervention using ABE was able to increase Hb levels (D% = 52.00±27.13 [ABE dose 10mg/kg]; 49.72±7.86 [ABE dose 50mg/kg] and 42.82±12.75 [ABE dose 30mg/kg]) significantly (p<0.05) when compared with the negative control (D% = 4.54±5.14), but when compared with the positive control (D% = 52.57±10.85) the average increase in Hb levels was not significant (p>0.05). In conclusion, our study showed that mice of the anemia model, intervened using ABE at doses of 10, 30, and 50mg/kg once daily for 14 days, experienced increased Hb levels.
Studi Etnofarmasi dan Skrining Fitokimia Kulit Batang Nelambo Suon (Rubiceae) Sebagai Antimalaria Suku Tehit Papua Watora, Wahyuni; Astuti, Ratih Arum; Rossardy, Marzella Dea
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.54145

Abstract

Abstrak Malaria masih menjadi permasalahan kesehatan di wilayah Papua, sehingga pemanfaatan tumbuhan obat tradisional tetap menjadi pilihan utama masyarakat pedalaman. Penelitian ini bertujuan untuk mendeskripsikan pemanfaatan tradisional tumbuhan Nelambo suon oleh masyarakat Suku Tehit di Distrik Teminabuan, Kabupaten Sorong Selatan, serta mengidentifikasi kandungan metabolit sekundernya melalui skrining fitokimia. Penelitian dilakukan melalui wawancara mendalam kepada informan lokal untuk memperoleh data pengetahuan, pengalaman, cara penggunaan, dan keyakinan terhadap efektivitas tanaman tersebut, serta uji fitokimia secara kualitatif terhadap ekstrak kulit batang. Hasil penelitian menunjukkan bahwa kulit batang Nelambo suon secara turun-temurun digunakan sebagai obat antimalaria, dengan cara direbus dan airnya diminum dua kali sehari hingga gejala berkurang. Analisis responden menunjukkan bahwa tingkat pengetahuan dan pengalaman tertinggi terdapat pada kelompok berpendidikan rendah (SD dan SMP), menandakan bahwa pengetahuan tradisional lebih dipengaruhi oleh pewarisan budaya dibandingkan pendidikan formal. Hasil skrining fitokimia menunjukkan adanya kandungan alkaloid, flavonoid, dan tanin, sedangkan saponin tidak terdeteksi. Senyawa-senyawa ini diketahui memiliki aktivitas antiplasmodium, antioksidan, serta antiinflamasi, sehingga mendukung potensi Nelambo suon sebagai kandidat obat tradisional antimalaria berbasis kearifan lokal. Kata Kunci: Etnofarmasi, Nelambo suon, antimalaria, skrining fitokimia. Abstract Malaria remains a major health problem in papua, making traditional medicinal plants an essential therapeutic option for remote communities. this study aims to describe the traditional use of nelambo suon by the tehit community in teminabuan district, south sorong regency, and to identify its secondary metabolites through phytochemical screening. data on traditional knowledge, experience, usage methods, and beliefs were collected through in-depth interviews with local informants, while qualitative phytochemical tests were performed on the stem bark extract. the results show that nelambo suon has been traditionally used for generations as an antimalarial remedy, prepared by boiling the stem bark and consuming the decoction twice daily until symptoms reduce. respondent analysis revealed that the highest levels of traditional knowledge and experience were found among those with lower formal education (elementary and junior high school), indicating that cultural transmission plays a greater role than formal schooling. phytochemical screening confirmed the presence of alkaloids, flavonoids, and tannins, while saponins were absent. these compounds possess antiplasmodial, antioxidant, and anti-inflammatory activities, supporting the potential of nelambo suon as a traditional antimalarial agent grounded in local wisdom. Keywords: ethnopharmacy, Nelambo suon, antimalarial, phytochemical screening.
Evaluasi Mutu Fisikokimia dan Aktivitas Antioksidan Minuman Isotonik Ekstrak Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) Khasanah, Nadziatul; Muslihin, A.M.; Rossardy, Marzella Dea; Fadli, Justitia Cahyani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1529

Abstract

as having potential as a natural antioxidant agent. One potential way to utilize this plant is by innovating it into an isotonic drink product. Objective: This study aimed to evaluate the physicochemical properties and antioxidant activity of an isotonic drink formulated with yellow rope stem extract. Methods: he extraction process was conducted using the maceration method with 70% ethanol as the solvent. The isotonic drink was developed into three formulas, which were then tested for their physicochemical properties and antioxidant activity using the DPPH method. Results: The results indicated that the best formula was FII, with an overall hedonic score of 4,6 (neutral). All three formulas showed identical pH values (4,0) and Total Soluble Solids (TSS) of 7%, while the total acidity decreased progressively: FI (1,024%), FII (0,896%), and FIII (0,704%). The isotonic drinks from yellow rope stem extract for formulas FI, FII, and FIII produced IC50 values of 35,61, 46,56, and 57,69 μg/mL, respectively. Based on these data, FI and FII were identified as having very strong antioxidant intensity, while the FIII showed activity classified in the strong category. Conclusion:.The test results demonstrate that the isotonic drink made from yellow rope stem extract exhibits antioxidant potential with intensity levels ranging from strong to very strong.
Co-Authors A. M. Muslihin Angga Bayu Budiyanto Aponno, Alyssa Mileta Astuti, Ratih Arum Azminah Fabanyo, Syahrul H. Fadli, Justitia Cahyani Irwandi Irwandi Khasanah, Nadziatul Lukman Hardia Utami, Hikmahtul Putri Watora, Wahyuni