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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Pharmaceutical and Sciences.
Rossardy, Marzella Dea
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Studi Fitokimia Senyawa Aktif Ekstrak Batang Nelambo suon (Rubiaceae) Rossardy, Marzella Dea; Muslihin, A.M.; Watora, Wahyuni; Budiyanto, Angga Bayu; Hardia, Lukman; Irwandi, Irwandi; Aponno, Alyssa Mileta; Utami, Hikmahtul Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1333

Abstract

Background: Papua has high biodiversity with significant potential as a source of traditional medicinal plants, including Nelambo suon (Rubiaceae), which has been empirically used by local communities. However, scientific information regarding the active compounds in its stem bark remains limited. Objective: This study aimed to identify the secondary metabolite groups present in the ethanol extract of Nelambo suon stem bark through phytochemical screening. Methods: The research was conducted experimentally using the maceration method with 80% ethanol as the solvent. The stem bark simplicia was extracted and qualitatively screened for alkaloids, flavonoids, tannins, and saponins using specific reagents. Results: The results showed that the ethanol extract of Nelambo suon stem bark contained alkaloids, flavonoids, tannins, and saponins, indicated by characteristic color changes, precipitate formation, and foam production. Conclusion: These findings suggest that Nelambo suon stem bark is a potential source of bioactive compounds and may be further developed as a herbal medicinal material based on local wisdom.
Efficacy of Akway (Drymis sp.) Bark Extract in Restoring Hemoglobin Levels: A Preclinical Study in a Sodium Nitrite-Induced Anemia Mice Model Lukman Hardia; Fabanyo, Syahrul H.; Budiyanto, Angga Bayu; Muslihin, A. M.; Rossardy, Marzella Dea; Irwandi, Irwandi; Watora, Wahyuni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44062

Abstract

The high prevalence of anemia prompted us to explore the potential of local herbs in Papua, Indonesia, which is known for its rich natural resources. In this study, we aim to conduct preclinical tests on anemia model test animals to validate the effectiveness of akway bark extract (ABE) as the basis for the development of effective and safe herbal antianemia drugs in the future. This study employs a quantitative analytical approach, utilizing an experimental design with a pre-posttest with a control group design. The research sample used 20 mice test animals, divided into 5 groups consisting of 4 animals each, namely: the control group (positive and negative), and the intervention group using ABE doses of 10, 30, and 50mg/kg. This study was approved by the Health Research Ethics Committee of STIFAR Makassar (Number: 299/EC.1.1.B/III/KEPK/2024). Data analysis showed that a 14-day intervention using ABE was able to increase Hb levels (D% = 52.00±27.13 [ABE dose 10mg/kg]; 49.72±7.86 [ABE dose 50mg/kg] and 42.82±12.75 [ABE dose 30mg/kg]) significantly (p<0.05) when compared with the negative control (D% = 4.54±5.14), but when compared with the positive control (D% = 52.57±10.85) the average increase in Hb levels was not significant (p>0.05). In conclusion, our study showed that mice of the anemia model, intervened using ABE at doses of 10, 30, and 50mg/kg once daily for 14 days, experienced increased Hb levels.
Co-Authors A. M. Muslihin Angga Bayu Budiyanto Aponno, Alyssa Mileta Fabanyo, Syahrul H. Irwandi Irwandi Lukman Hardia Utami, Hikmahtul Putri Watora, Wahyuni