Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh
Irwanda, Desi Danilah
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Effects Of Combination Sunkist and Lime Peel Nanoparticle Granules on Oxidative Stress and Heart Histopathology in Diabetes Rats Sihotang, Widya Yanti; Mutia, Maya Sari; Chairul, Muhammad; Irwanda, Desi Danilah; Nabila, Putri; Hamsi, Ulpah Zahara
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 10 No.2 November 2024
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v10i2.18973

Abstract

Diabetes mellitus and its consequences are significantly influenced by oxidative stress. Sunkist and lime oranges are a nutritional powerhouse, offering a range of health benefits due to their high content of antioxidants, vitamins, minerals, and fiber. Key compounds like anthocyanins, flavanones, and hydroxycinnamic acid contribute to their potential positive impact to reduce oxidative stress. Therefore, the effect of nanoparticle granules combination of sunkist orange peel and lime peel was investigated on diabetic rats. Twenty male Wistar rats were randomly distributed:  Group 1 as control group given distilled water, Group 2 as DM group with alloxan, Group 3 with DM + NGSLP 100mg / kgBW, Group 4 with DM + NGSLP 200mg / kgBW. Rats with diabetes were treated by intraperitoneal injection with 100 mg/kg alloxan. NGSLP treatment was given for 14 days to each treatment group. At the end, the blood and heart tissue were collected and used to determine the GPx enzyme, SOD, MDA, CAT and histological evaluation. Diabetes induction increased the level of MDA and decreased after treated with NGSLP. In diabetic rats treated with NGSLP showed an increase in SOD, GPX and CAT in blood. Histopathological findings of heart tissue showed the protective effect of NGSLP in rats with diabetic. This study revealed that NGSLP has antioxidant effects in the blood and heart of alloxan-induced diabetic rats.
Co-Authors Chairul, Muhammad Hamsi, Ulpah Zahara Mutia, Maya Sari Nabila, Putri Widya Yanti Sihotang