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All Journal Jurnal Maternitas Kebidanan AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh
Hamsi, Ulpah Zahara
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Effects Of Combination Sunkist and Lime Peel Nanoparticle Granules on Oxidative Stress and Heart Histopathology in Diabetes Rats Sihotang, Widya Yanti; Mutia, Maya Sari; Chairul, Muhammad; Irwanda, Desi Danilah; Nabila, Putri; Hamsi, Ulpah Zahara
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 10 No.2 November 2024
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v10i2.18973

Abstract

Diabetes mellitus and its consequences are significantly influenced by oxidative stress. Sunkist and lime oranges are a nutritional powerhouse, offering a range of health benefits due to their high content of antioxidants, vitamins, minerals, and fiber. Key compounds like anthocyanins, flavanones, and hydroxycinnamic acid contribute to their potential positive impact to reduce oxidative stress. Therefore, the effect of nanoparticle granules combination of sunkist orange peel and lime peel was investigated on diabetic rats. Twenty male Wistar rats were randomly distributed:  Group 1 as control group given distilled water, Group 2 as DM group with alloxan, Group 3 with DM + NGSLP 100mg / kgBW, Group 4 with DM + NGSLP 200mg / kgBW. Rats with diabetes were treated by intraperitoneal injection with 100 mg/kg alloxan. NGSLP treatment was given for 14 days to each treatment group. At the end, the blood and heart tissue were collected and used to determine the GPx enzyme, SOD, MDA, CAT and histological evaluation. Diabetes induction increased the level of MDA and decreased after treated with NGSLP. In diabetic rats treated with NGSLP showed an increase in SOD, GPX and CAT in blood. Histopathological findings of heart tissue showed the protective effect of NGSLP in rats with diabetic. This study revealed that NGSLP has antioxidant effects in the blood and heart of alloxan-induced diabetic rats.
Ekstrak Granul Nanopartikel Kulit Jeruk Sunkist (Citrus Sinensis (L.) Osbeck) Dan Ekstrak Kulit Jeruk Nipis (Citrus Aurantifolia) Terhadap Gambaran Perlemakan Hati Pada Tikus (Rattus Norvegicus) Model Diabetes) Mutia, Maya Sari; Nabila, Putri; Hamsi, Ulpah Zahara; Lubis, Yolanda Eliza Putri
Jurnal Maternitas Kebidanan Vol. 9 No. 2 (2024): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v9i2.5623

Abstract

Sunkist oranges (Citrus sinensis (L.) Osbeck have a high content of anthocyanins (95% of which are cyanidin-3-glucoside and cyanidine-3-6"-malonyl-glucoside), flavanone (hesperidin and narirutin), as well as hydroxynamic acid (caffeic acid, cumaric acid, cinnamic acid, and ferulic acid), carotenoids, sugars, minerals, and fiber, considered a good food source of bioactive substances with beneficial effects on health. This study aims to examine the potential for liver improvement in mice with a diabetes model after the administration of nanoparticle granules combining sunkist orange peel and lime peel. The design of this experimental research is Post Test Only Control Group Design. Twenty-five male rats of the wistar strain were used which were divided into 5 groups at random, namely the negative control group (aloxan), the positive control group (aquadest), Treatment 1 (aloxan + nanoparticle granules 50mg/kgBB), Treatment 2 (aloxan + nanoparticle granules 100mg/kgBB) Treatment 3 (aloxan + nanoparticle granules 200mg/kgBB). The liver organ was prepared for observation with 10x ocular magnification and 40x objective lens magnification. Liver improvement had an effect on the decrease of SGPT, SGOT, and Histopathological picture of the liver in diabetic model mice after the administration of nanoparticle granules combined with sunkist orange peel and lime peel at concentrations of 50 mg/KgBB, 100 mg/KgBB and 200 mg/KgBB showed significant differences. The best liver improvement is by administering nanoparticle granules a combination of sunkist orange peel and lime peel at a concentration of 200 mg/KgBB. Keyword: Diabetes Mellitus, Sunkist orange and lime peel extracts, fatty live.  
Co-Authors Chairul, Muhammad Irwanda, Desi Danilah Mutia, Maya Sari Nabila, Putri Widya Yanti Sihotang Yolanda Eliza Putri Lubis