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The Effects of Black Garlic on Ovarian Malondialdehyde, Oviduct Muscle, and Endometrial Arterioles in Smoke-Exposed Rats Anandasari, Noni Fidya Ayu; Kridayanti, Novalia; Kaspirayanthi, Ni Ketut Devy; Nurseta, Tatit; Raras, Tri Yudani Mardining; Khotimah, Husnul; Reksohusodo, Subandi; Anita, Kenty Wantri; Yudhanto, Hendy Setyo
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1533

Abstract

The effect of cigarette smoke exposure on reproductive health has been widely studied, showing various physiological disorders induced by free radicals and oxidative stress. This study aimed to assess the protective effect of ethanol extract of black garlic (Allium sativum) on some reproductive parameters of female rats Rattus norvegicus exposed to subacute cigarette smoke. A proper experimental method with a post-test-only control group design was used, involving 25 rats divided into five groups with three different doses of the extract. The rats were exposed to cigarette smoke and then treated for 28 days. Results showed a significant decrease in ovarian Malondialdehyde levels and increased fallopian tube smooth muscle thickness in the extract-treated group. In addition, black garlic extract successfully increased the number of endometrial arterioles in the group exposed to cigarette smoke and extract, in contrast to the group exposed to cigarette smoke only. This study concludes that black garlic extract has the potential to be a protective agent against oxidative damage in the reproductive system of rats exposed to cigarette smoke, with effectiveness that depends on the dose of extract given. Further studies should investigate the long-term effects and optimal dosing of black garlic extract in humans. Additionally, exploring the molecular mechanisms behind its protective properties could enhance its application in reproductive health management.                 
Analysis of the Effect of Black Garlic (Allium sativum) Extract on Ovarian Follicular Atresia, Endometrial VEGF Expression, and Fallopian Tube Epithelial Cell Count in Rats (Rattus norvegicus) Exposed to Cigarette Smoke Kridayanti, Novalia; Anandasari , Noni Fidya Ayu; Kaspirayanthi, Ni Ketut Devy; Nurseta, Tatit; Raras, Tri Yudani Mardining; Khotimah, Husnul; Reksohusodo, Subandi; Angelica, Aina; Anita, Kenty Wantri; Yudhanto, Hendy Setyo
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1535

Abstract

Cigarette smoke exposure significantly impairs reproductive function in Rattus norvegicus. This study evaluated the protective effects of black garlic extract against such damage. Using a post-test-only control group design, 25 female Wistar rats were divided into five groups and exposed to cigarette smoke with or without varying doses of black garlic extract. After four weeks, results indicated that black garlic extract significantly increased Vascular Endothelial Growth Factor expression, enhanced fallopian tube secretory epithelial cell counts, and reduced ovarian follicular atresia in rats exposed to cigarette smoke. The group receiving 50 mg/kgBW of black garlic extract showed the most significant improvements. Statistical analysis, including One-way ANOVA, revealed significant differences between groups. Normality was assessed using the Shapiro-Wilk test, and homogeneity was confirmed with the Levene test. Significant decreases in ovarian follicular atresia (p < 0.05) and increases in Vascular Endothelial Growth Factor expression (p < 0.05) and secretory epithelial cell counts (p < 0.05) were observed in the 50 mg/kgBW treatment group compared to controls. In conclusion, black garlic extract offers dose-dependent protection against cigarette smoke-induced reproductive damage, with 50 mg/kgBW being the optimal dose. Further research should explore molecular mechanisms, long-term toxicity, and clinical applications in humans.              
A Positive Communication–Based Family Counseling to Prevent Mental and Reproductive Health Problems among Adolescents: Konseling Keluarga Berbasis Komunikasi Positif untuk Mencegah Masalah Kesehatan Mental dan Reproduksi pada Remaja KASPIRAYANTHI, NI KETUT DEVY
Jurnal Abdi Mahosada Vol. 4 No. 1 (2026): Jurnal Pengabdian Kepada Masyarakat Tahun 2026
Publisher : STIKES Advaita Medika Tabanan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54107/abdimahosada.v4i1.444

Abstract

Abstract Remaja merupakan periode transisi yang rentan terhadap masalah kesehatan mental, perilaku berisiko seperti penyalahgunaan zat, seks pranikah, dan pernikahan dini, yang sangat dipengaruhi oleh kualitas dukungan dan komunikasi dalam keluarga. Berbagai studi terkini menunjukkan bahwa konseling keluarga dan komunikasi orang tua–remaja yang positif berperan penting dalam menurunkan kecemasan, depresi, perilaku adiktif digital, serta meningkatkan perilaku kesehatan reproduksi remaja. Artikel ini bertujuan mendeskripsikan model konseling keluarga berbasis komunikasi positif untuk memperkuat peran keluarga dalam pencegahan masalah kesehatan mental dan reproduksi pada remaja. Metode yang diusulkan adalah pengabdian masyarakat berupa edukasi kesehatan, pelatihan komunikasi positif, dan sesi konseling keluarga berkala dengan melibatkan remaja dan orang tua. Diharapkan intervensi ini meningkatkan pengetahuan keluarga tentang kesehatan reproduksi remaja, memperbaiki kualitas komunikasi, dan menurunkan faktor risiko psikososial remaja. Kata kunci: konseling keluarga, remaja, komunikasi positif, kesehatan mental, kesehatan reproduksi. Abstract Adolescents are in a critical transitional phase and are highly vulnerable to mental health problems and risky behaviors, including substance abuse, premarital sexual activity, and early marriage. These issues are closely related to inadequate family support and ineffective communication between parents and adolescents. Recent evidence highlights the effectiveness of family counseling and positive parent–adolescent communication in reducing anxiety, depression, digital addictive behaviors, and in promoting healthy reproductive behaviors among adolescents.This grant proposal aims to develop and implement a family counseling model based on positive communication to strengthen family capacity in preventing mental and reproductive health problems among adolescents. The program will be conducted as a community-based intervention comprising reproductive health education, positive communication skills training for parents and adolescents, and structured family counseling sessions delivered periodically. The expected outcomes of this program include increased family knowledge of adolescent mental and reproductive health, improved quality of parent–adolescent communication, reduced psychosocial risk factors, and enhanced protective behaviors among adolescents. This program is expected to contribute to sustainable family-based prevention efforts and support national adolescent health promotion initiatives Keywords: family counseling, adolescents, positive communication, mental health, reproductive health.Top of Form