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All Journal Proceeding Mulawarman International Conference on Tropical Public Health Jurnal Info Kesehatan
Nanda, Britania Laila
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Public Health

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The Effect of Sub-Acute Inhalation Exposure to Polyethylene Micro-Nano Plastics on the Histopathological Features of the Mammary Glands in Female Wistar White Rats (Rattus Norvegicus) Kusuma, Ihda Dian; Janasti, Laksmitha; Sari, Riana Trinovita; Nanda, Britania Laila; Sulistomo, Hikmawan Wahyu; Nurdiana, Nurdiana
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1534

Abstract

Most household appliances are made of plastic derived from synthetic petroleum and result from polymerization processes. One type of plastic is Polyethylene (PE). Polyethylene (PE) contains antimony trioxide compounds that are carcinogenic if ingested in excessive amounts, triggering cancer and oxidative stress. This effect can be assessed by measuring malondialdehyde (MDA) levels in the body. This study aims to determine the proliferation of abnormal cells in the lactiferous ducts and mammary gland acini, as well as the increase in MDA levels. The research method used is a true experimental design with a Randomized Post Test Only Group Design. This study used the mammary organs and blood of female white rats exposed to PE for 28 days. The number of samples used in this study was 12 female white rats. The results showed significant differences in the mammary glands' histopathological features and MDA levels. Based on the Independent T-Test results on the number of cell layers in the lactiferous ducts, acini, and the number of acini (p<0.05) and the Mann-Whitney test on MDA levels (p<0.05). Significant changes in the histopathological features and MDA levels were observed in the mammary glands exposed to polyethylene (PE) plastic. Exposure to micro-nano plastics of PE type at a dose of 15 mg/m3 for 28 days differed significantly in the MDA levels of mammary glands, histopathological picture of mammary glands at cell proliferation events, both in the lactiferous ducts and acini cells. In addition, exposure to PE plastic has the potential to cause health problems in the breast organs if exposed for a long time and in excess doses.
Maternal Mental Well-Being and Infant Feeding Outcomes: A Systematic Review and Meta-analysis Kurniasari, Eri; Chusna, Safira Mauliyatul; Farokah, Atik; Nanda, Britania Laila; Maharani, Wafa Aulia; Fitriana, Salsabila; Pramesti, Zelin Patarena Dawi
Mulawarman International Conference on Tropical Public Health Vol. 2 No. 2 (2025): The 4th MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

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Abstract

Background : Maternal mental well-being is a crucial determinant of infant feeding outcomes. Psychological conditions such as postpartum depression, anxiety, and stress may influence a mother’s ability and motivation to initiate or sustain breastfeeding. However, the direction and magnitude of this association remain unclear. Objective : This systematic review and meta-analysis aimed to assess the association between maternal mental well-being and infant feeding outcomes, including exclusive breastfeeding practices. Research Methods/ Implementation Methods : A comprehensive literature search was conducted in Scopus, ScienceDirect, and PubMed databases for studies published between 2015-2025. Both observational and interventional studies examining maternal mental health and infant feeding outcomes were included. Data were synthesized using a random-effects model following PRISMA guidelines. Results : Three studies met the inclusion criteria and were included in the meta-analysis. The pooled odds ratio indicated no statistically significant association between maternal mental well-being and infant feeding outcomes (OR = 0.61; 95% CI = 0.18–2.00; p = 0.41). Considerable heterogeneity was observed among studies (I² = 87%), which may be attributed to variations in study design, population characteristics, and measurement instruments Conclusion/Lesson Learned : Although several individual studies suggest that poor maternal mental health may adversely affect breastfeeding and other infant feeding practices, the pooled results did not reveal a significant association. The high heterogeneity highlights the need for future longitudinal studies with standardized assessments of maternal mental well-being and infant feeding behaviors.
Co-Authors Atik Farokah Chusna, Safira Mauliyatul Fitriana, Salsabila Ihda Dian Kusuma Janasti, Laksmitha Kurniasari, Eri Maharani, Wafa Aulia Nurdiana Nurdiana Pramesti, Zelin Patarena Dawi Sari, Riana Trinovita Sulistomo, Hikmawan Wahyu