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All Journal Biomedical Journal of Indonesia Majalah Kesehatan FKUB
Sulistomo, Hikmawan Wahyu
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Tinjauan Literatur: POTENSI TERAPI ANTIKANKER ANGGUR LAUT Caulerpa sp. (A SYSTEMATIC REVIEW) Tertiana, Nur Iedha; Permatasari, Happy Kurnia; Sulistomo, Hikmawan Wahyu
Majalah Kesehatan Vol. 12 No. 2 (2025): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2025.012.02.10

Abstract

Kanker adalah penyakit kompleks yang membunuh jutaan orang setiap tahunnya. Menurut World Health Organization (WHO), kanker merupakan penyebab utama kedua kematian di dunia. Kegagalan kemoterapi dilaporkan menjadi masalah serius dan penyebab terjadinya resistensi obat antikanker. Produk alami hasil laut telah digunakan sebagai senyawa untuk penemuan obat. Senyawa polisakarida, polifenol, dan sterol terdapat di dalamnya dan memiliki sifat antioksidan, antiinflamasi, antidiabetes, antikoagulan, dan antikanker. Penelitian ini bertujuan untuk membahas potensi Caulerpa sp. sebagai alternatif agen antikanker baru. Penelusuran pustaka menggunakan mesin pencarian yaitu pada database Pubmed, SpringerLink, dan ScienceDirect. Teknik yang digunakan adalah Boolean operator untuk menghubungkan kata kunci. Dari 14 literatur didapatkan potensi anggur laut Caulerpa sp. sebagai agen antikanker melalui berbagai mekanisme di antaranya adalah induksi apoptosis, aktivitas sitotoksik, dan antiproliferatif. Aktivitas antikanker Caulerpa sp. disebabkan kinerja berbagai kandungan metabolit sekunder pada Caulerpa sp. di antaranya alkaloid bisindole, terpenoid, seskuiterpenoid, diterpenoid, caulerpin, caulersin, racemosin, dan caulerpenyne. Anggur laut Caulerpa sp memiliki potensi yang baik sebagai agen antikanker melalui induksi apoptosis, aktivitas sitotoksik, serta mekanisme antiproliferasi  
Effect of Curcumin Nanoemulsion on Brain Cell Development, Locomotor Function, and Mortality of Zebrafish Larvae Model of Gestational Diabetes Mellitus Subandi, Subandi; Azahra, Mutiara Syifa; Ovinery, Amarsya; Akhmalia, Qorry' Afyu; Asih, Aliyah Tresna; Sulistomo, Hikmawan Wahyu; Nurdiana, Nurdiana; Wiyasa, I Wayan Arsana
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.270

Abstract

Introduction. Gestational diabetes mellitus (GDM) is glucose intolerance in pregnancy due to reduced ability of pancreatic beta cells to produce insulin, causing oxidative stress that triggers various complications such as brain apoptosis to locomotor disorders and decreased head size which has an impact on mortality rates. Pharmacological treatment of GDM has side effects that risk affecting fetal development. Therefore, curcumin as a herbal medicine can be an option for GDM treatment because it can increase insulin sensitivity by activating the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) receptor. Methods. Post Test Only Control Group Design was used in this experimental study which was tested on each research variable consisting of 25 zebrafish embryos divided into 5 treatment groups consisting of a negative control, a positive control exposed to 3% glucose, and a diabetic group given curcumin nanoemulsion with three different doses (0.3125 μg/ml, 0.625 μg/ml, 1.25 μg/ml). One Way ANOVA and Post Hoc Tukey tests were used to analyze the data from this study. Results. P value from One Way ANOVA test p=0.024 for brain apoptosis, p=0.00 for locomotor ability, p=0.04 for head size, and p=0.006 for mortality rate. Turkey Post Hoc test showed significant differences in the control and 3% glucose + 0.625 µg/ml curcumin nanoemulsion groups (p<0.05). Conclusion. Curcumin nanoemulsion therapy has an effect on decreasing brain apoptosis, increasing locomotor, inhibiting the decrease in head size, and decreasing the mortality rate in zebrafish with gestational diabetes. The most effective dose of curcumin nanoemulsion is 0.625 µg/ml.
Co-Authors Akhmalia, Qorry' Afyu Asih, Aliyah Tresna Azahra, Mutiara Syifa Bambang Rahardjo Gusti, Kharisma Ciptaning Happy Kurnia Permatasari Ihda Dian Kusuma Janasti, Laksmitha Kusworini Handono Nanda, Britania Laila Nurdiana Nurdiana Ovinery, Amarsya Safrina Dewi Ratnaningrum, Safrina Dewi Sari, Riana Trinovita Setyowati, Anisa Situmorang, Melani Chysti Subandi Subandi Subandi Subandi Sulistiani, Ita Tertiana, Nur Iedha Wardani, Dewi Azar Nuria Wiyasa, I Wayan Arsana