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All Journal Biomedical Journal of Indonesia Majalah Kesehatan FKUB Jurnal Info Kesehatan
Sulistomo, Hikmawan Wahyu
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Tinjauan Literatur: POTENSI TERAPI ANTIKANKER ANGGUR LAUT Caulerpa sp. (A SYSTEMATIC REVIEW) Tertiana, Nur Iedha; Permatasari, Happy Kurnia; Sulistomo, Hikmawan Wahyu
Majalah Kesehatan Vol. 12 No. 2 (2025): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2025.012.02.10

Abstract

Kanker adalah penyakit kompleks yang membunuh jutaan orang setiap tahunnya. Menurut World Health Organization (WHO), kanker merupakan penyebab utama kedua kematian di dunia. Kegagalan kemoterapi dilaporkan menjadi masalah serius dan penyebab terjadinya resistensi obat antikanker. Produk alami hasil laut telah digunakan sebagai senyawa untuk penemuan obat. Senyawa polisakarida, polifenol, dan sterol terdapat di dalamnya dan memiliki sifat antioksidan, antiinflamasi, antidiabetes, antikoagulan, dan antikanker. Penelitian ini bertujuan untuk membahas potensi Caulerpa sp. sebagai alternatif agen antikanker baru. Penelusuran pustaka menggunakan mesin pencarian yaitu pada database Pubmed, SpringerLink, dan ScienceDirect. Teknik yang digunakan adalah Boolean operator untuk menghubungkan kata kunci. Dari 14 literatur didapatkan potensi anggur laut Caulerpa sp. sebagai agen antikanker melalui berbagai mekanisme di antaranya adalah induksi apoptosis, aktivitas sitotoksik, dan antiproliferatif. Aktivitas antikanker Caulerpa sp. disebabkan kinerja berbagai kandungan metabolit sekunder pada Caulerpa sp. di antaranya alkaloid bisindole, terpenoid, seskuiterpenoid, diterpenoid, caulerpin, caulersin, racemosin, dan caulerpenyne. Anggur laut Caulerpa sp memiliki potensi yang baik sebagai agen antikanker melalui induksi apoptosis, aktivitas sitotoksik, serta mekanisme antiproliferasi  
Effect of Curcumin Nanoemulsion on Brain Cell Development, Locomotor Function, and Mortality of Zebrafish Larvae Model of Gestational Diabetes Mellitus Subandi, Subandi; Azahra, Mutiara Syifa; Ovinery, Amarsya; Akhmalia, Qorry' Afyu; Asih, Aliyah Tresna; Sulistomo, Hikmawan Wahyu; Nurdiana, Nurdiana; Wiyasa, I Wayan Arsana
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.270

Abstract

Introduction. Gestational diabetes mellitus (GDM) is glucose intolerance in pregnancy due to reduced ability of pancreatic beta cells to produce insulin, causing oxidative stress that triggers various complications such as brain apoptosis to locomotor disorders and decreased head size which has an impact on mortality rates. Pharmacological treatment of GDM has side effects that risk affecting fetal development. Therefore, curcumin as a herbal medicine can be an option for GDM treatment because it can increase insulin sensitivity by activating the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) receptor. Methods. Post Test Only Control Group Design was used in this experimental study which was tested on each research variable consisting of 25 zebrafish embryos divided into 5 treatment groups consisting of a negative control, a positive control exposed to 3% glucose, and a diabetic group given curcumin nanoemulsion with three different doses (0.3125 μg/ml, 0.625 μg/ml, 1.25 μg/ml). One Way ANOVA and Post Hoc Tukey tests were used to analyze the data from this study. Results. P value from One Way ANOVA test p=0.024 for brain apoptosis, p=0.00 for locomotor ability, p=0.04 for head size, and p=0.006 for mortality rate. Turkey Post Hoc test showed significant differences in the control and 3% glucose + 0.625 µg/ml curcumin nanoemulsion groups (p<0.05). Conclusion. Curcumin nanoemulsion therapy has an effect on decreasing brain apoptosis, increasing locomotor, inhibiting the decrease in head size, and decreasing the mortality rate in zebrafish with gestational diabetes. The most effective dose of curcumin nanoemulsion is 0.625 µg/ml.
The Effect of Sub-Acute Inhalation Exposure to Polyethylene Micro-Nano Plastics on the Histopathological Features of the Mammary Glands in Female Wistar White Rats (Rattus Norvegicus) Kusuma, Ihda Dian; Janasti, Laksmitha; Sari, Riana Trinovita; Nanda, Britania Laila; Sulistomo, Hikmawan Wahyu; Nurdiana, Nurdiana
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1534

Abstract

Most household appliances are made of plastic derived from synthetic petroleum and result from polymerization processes. One type of plastic is Polyethylene (PE). Polyethylene (PE) contains antimony trioxide compounds that are carcinogenic if ingested in excessive amounts, triggering cancer and oxidative stress. This effect can be assessed by measuring malondialdehyde (MDA) levels in the body. This study aims to determine the proliferation of abnormal cells in the lactiferous ducts and mammary gland acini, as well as the increase in MDA levels. The research method used is a true experimental design with a Randomized Post Test Only Group Design. This study used the mammary organs and blood of female white rats exposed to PE for 28 days. The number of samples used in this study was 12 female white rats. The results showed significant differences in the mammary glands' histopathological features and MDA levels. Based on the Independent T-Test results on the number of cell layers in the lactiferous ducts, acini, and the number of acini (p<0.05) and the Mann-Whitney test on MDA levels (p<0.05). Significant changes in the histopathological features and MDA levels were observed in the mammary glands exposed to polyethylene (PE) plastic. Exposure to micro-nano plastics of PE type at a dose of 15 mg/m3 for 28 days differed significantly in the MDA levels of mammary glands, histopathological picture of mammary glands at cell proliferation events, both in the lactiferous ducts and acini cells. In addition, exposure to PE plastic has the potential to cause health problems in the breast organs if exposed for a long time and in excess doses.
Evaluation of Hematotoxicity in Female Wistar Rats Following Sub-Acute Inhalation Exposure to Polyethylene Microplastic Sulistomo, Hikmawan Wahyu; Setyowati, Anisa; Situmorang, Melani Chysti; Sulistiani, Ita; Wardani, Dewi Azar Nuria; Gusti, Kharisma Ciptaning; Nurdiana, Nurdiana; Kusuma, Ihda Dian; Rahardjo, Bambang; Reksohusodo, Subandi
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1585

Abstract

Polyethylene (PE) becomes a source of microplastics that can be widely distributed through the digestive and respiratory systems. However, its effects on blood cells are still being investigated. This study aims to analyze the impact of Polyethylene Microplastic (PE-MPs) exposure on the blood of female rats, including erythrocytes, leukocytes, and platelets. This study used female Wistar rats, which were divided into control and PE-MP groups. PE-MP was administered via whole-body inhalation at a concentration of 15 mg/m³ for 4 hours daily for 28 days. The absorption of plastic particles detected in the human bloodstream is likely to occur through mucosal contact (either through ingestion or inhalation). After the exposure period, the rats were euthanized to collect blood samples through the heart. A complete blood count was performed using an automatic hematology analyzer, and blood morphology was analyzed using thin blood smears. This study used the Mann-Whitney test. PE-MP exposure increased erythrocyte and platelet counts without a corresponding rise in leukocytes. Erythrocytes showed abnormal morphology (12.73% with ovalocytes and tear-shaped cells). Erythrocyte indices (MCV, MCH, MCHC) showed no significant differences. Platelet count rose by 1.7% (p-value= 0.017). Leukocyte and neutrophil counts were lower (0.84 and 0.94 times lower, respectively), while lymphocytes and monocytes were higher (1.03 and 1.61 times higher, respectively) in the PE-MP group compared to controls. The neutrophil-to-lymphocyte ratio did not differ significantly. PE-MP exposure in rats disrupts blood parameters, altering erythrocyte morphology and increasing platelet counts. Potential causes include oxidative stress, immune responses, and compensatory mechanisms. Study limitations include a small sample size and exclusive focus on inhalation exposure. Integrating multiple exposure routes (inhalation, ingestion, dermal) could offer a broader view of microplastic impacts. Future research with larger samples, diverse doses and durations, and exploration of additional markers or organ-specific effects is crucial for understanding PE-MP toxicity in real-world scenarios.               
The Effect of Sub-Acute Inhalation Exposure to Polyethylene and Polyvinyl Chloride Micro-Nano Plastics on the Superoxide Dismutase (SOD) Level and Malondialdehyde (MDA) Level in Rat Ovary Sulistomo, Hikmawan Wahyu; Janasti, Laksmitha; Sari, Riana Trinovita; Kusworini, Kusworini; Ratnaningrum, Safrina Dewi; Kusuma, Ihda Dian; Nurdiana, Nurdiana
JURNAL INFO KESEHATAN Vol 22 No 3 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss3.1612

Abstract

Plastic is a synthetic or semi-synthetic organic polymer widely used in daily life and industrial production. Microplastics are widespread contaminants and can enter the human body by consuming foods containing microplastics, inhaling microplastics in the air, and making skin contact with microplastic particles in products. Microplastics can enter the ovaries as foreign bodies and can cause inflammation, oxidative stress, and even ovarian granulosa cell death. Polyethylene plastic shards generally have a higher ability to absorb environmental toxins than other types of plastic. Polyvinyl chloride (PVC) is one of the oldest thermoplastic polymers that is often used as water pipes. PVC has carcinogenic monomers and some harmful additives. This study aims to determine the effect of subacute exposure to micro-nanoplastics per inhalation on SOD and MDA levels in rat ovaries. The research method used is a true experimental design with a Randomize Post Test Only Group Design research design. This study used the ovarian organs of female white rats exposed to PVC and PE for 28 days. The number of samples used in this study amounted to 18 female rats. Subacute exposure to micro-nanoplastics per inhalation can lower SOD levels and significantly increase MDA levels in rat ovaries. This study is expected to provide knowledge and an overview for future research on the mechanism of toxicity of micro-nanoplastic exposure that has an impact on female infertility through free radicals in the ovaries.                   
Co-Authors Akhmalia, Qorry' Afyu Asih, Aliyah Tresna Azahra, Mutiara Syifa Bambang Rahardjo Gusti, Kharisma Ciptaning Happy Kurnia Permatasari Ihda Dian Kusuma Janasti, Laksmitha Kusworini Handono Nanda, Britania Laila Nurdiana Nurdiana Ovinery, Amarsya Safrina Dewi Ratnaningrum, Safrina Dewi Sari, Riana Trinovita Setyowati, Anisa Situmorang, Melani Chysti Subandi Subandi Subandi Subandi Sulistiani, Ita Tertiana, Nur Iedha Wardani, Dewi Azar Nuria Wiyasa, I Wayan Arsana