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All Journal Jurnal Biosains Pascasarjana Jurnal Farmamedika (Pharmamedica Journal) Journal of Medical Laboratory in Infectious and Degenerative Diseases
Anggia Destiawan, Rian
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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EFFECT OF Clitoria ternatea INFUSION ON THE NEUTROPHIL CELLS AND LYMPHOCYTE CELLS IN A MODEL OF Salmonella typhimurium INFECTION Anggia Destiawan, Rian; Imroatul Muflihah, Ahdiah; Hidayati, Sholihatil; Hariani Nurjanah, Mutia; Sandi Basuki, Aditya Occy; Asista Indarusanti, Delvia; Hayati, Farhatul; Amalia, Nabila
Jurnal Biosains Pascasarjana Vol. 26 No. 2 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i2.2024.185-192

Abstract

Salmonellosis is caused by infection with the bacterium Salmonella sp. which causes immune dysregulation and damage to digestive epithelial cells. So there is a need to increase immunity to fight Salmonella sp. The purpose of this study is to determine the effect of telang flower infusion on the number of Nuetrophophil cells and Lomfosyte cells on Salmonella typhimurium infection. The study was divided into 6 groups, negative, positive, Stimuno (0.26ml/20gBB), therapy 1 (0.25 ml/20gBB), therapy 2 (0.5 ml/20gBB), therapy 3 (1 ml/20gBB). Infusion making, Bacterial infection, infusa therapy, Giemsa staining, and 95% p-value data analysis. The results showed that there was a significant difference in the number of neutrophil cells in each group (p<0.05). Meanwhile, the number of lymphocytes after the anova test showed a significant increase in the number of lymphocytes (0.00<0.05). The conclusion of this study is that the infusion of telang flowers from low to high doses has an effect on increasing the number of neutrophil cells and lymphocyte cells
EVALUASI FORMULA DAN AKTIVITAS ANTIOKSIDAN SEDIAAN GRANUL EFFERVESCENT DAUN PEPAYA JEPANG (CNIDOSCOLUS ACONITIFOLIUS) Hidayati, Sholihatil; Ayu Susanti, Dhina; Anggia Destiawan, Rian; Angger Putri M. Soleh, Ayu; Salsa Safitri, Avrillia; Kalyana Meta, Nilanda
Jurnal Farmamedika (Pharmamedika Journal) Vol 9 No 2 (2024): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v9i2.413

Abstract

Stres oksidatif bertanggung jawab pada permulaan dan/atau perkembangan beberapa penyakit kanker, diabetes, gangguan metabolisme, aterosklerosis, dan penyakit kardiovaskular. Antioksidan dapat menghambat ROS melalui proses donor elektron sehingga ROS lebih stabil. Antioksidan alami dapat menurunkan insiden penyakit degeneratif akibat stres oksidatif dan meningkatkan kapasitas antioksidan dalam tubuh. Salah satu sumber bahan alam yang berpotensi sebagai antioksidan daun papaya jepang. Penelitian ini bertujuan untuk mencari formulasi terbaik ekstrak daun papaya jepang dalam sediaan granul effervescent. penelitian dilakukan dengan membuat formulasi granul effervescent dengan metode granulasi basah dengan perbedaan konsentrasi mannitol dan PVP sebagai bahan pengikat. Evaluasi mutu fisik terdiri atas uji laju aliran dan penentuan sudut istirahat, bulk density, tapped density, compressibility index (CI) dan hausner ratio (HR), waktu buih, stabilitas fisik. aktivitas antioksidan di lakukan dengan metode DPPH menggunakan instrument spektrofotometer pada Panjang gelombang 517 nm. Analisis data dilakukan dengan menggunakan aplikasi SPSS uji anova dan uji lanjutan post hoc (Tukey) dengan nilai signifikansi di p<0,05. Berdasarkan hasil evaluasi granul effervescent daun pepaya jepang pada formula FI, FII dan FIII telah memenuhi standar dengan hasil laju alir 6,25 g/mL - 7,17 g/mL, sudut istirahat 25,75o - 28,18°, tapped density 0,50 g/mL - 0,55 g/mL, compressibility index 5,78% -14,49%, hausner ratio 0,855 - 0,92, waktu buih 1 menit 31 detik - 1 menit 33 detik, organoleptis berwarna hijau tua, berbentuk granul kasar, aroma khas pepaya dengan pH 5,4 - 5,6 dan kadar lembab 0,62% - 84%. Aktivitas antioksidan dengan nilai IC50 adalah FI 22,75 μg/mL, FII 26,87 μg/mL dan FIII 24,84 μg/mL. Kesimpulan dari penelitian ini adalah formulasi FI merupakan formulasi terbaik yang diperoleh dari formulasi granul effervescent daun pepaya jepang karena mempunyai sifat fisik yang baik dan mempunyai aktivitas antioksidan paling kuat.
Effectiveness of The Larvicide Combination Extract of Basil (Ocimum basilicum) Leaves And Soursop (Annona muricata) Leaves Against Aedes aegypti Larva Shafrina Rohma, Hanna; Mufidah, Hartalina; Anggia Destiawan, Rian; Trianggaluh Fauziah, Dina
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 2 No. 2 (2024): December
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v2i2.28

Abstract

Background: Dengue hemorrhagic fever (DHF) is an acute febrile illness caused by dengue virus infection which is transmitted through the bite of the Aedes aegypti mosquito. An alternative method that can be used is a vegetable larvicide to eradicate Aedes aegypti larvae. Basil leaf extracts (Ocimum basilicum) and soursop leaves (Annona muricata) contain flavonoids, saponins, alkaloids, tannins and essential oils as larvicide compounds. Purpose: This study aims to determine the effectiveness of the larvicidal combination of basil (Ocimum basilicum) and soursop (Nnona muricata) leaf extracts against Aedes aegypti larvae at concentrations of 5%, 10%, 15% and 20%. Methods: This type of research is descriptive quantitative research with an experimental design. This study used 6 samples of Aedes aegypti larvae at each concentration. The treatment stage was carried out by adding a combination of basil (Ocimum basilicum) and soursop leaf (Annona muricata) leaf extracts in concentrations of 5%, 10%, 15% and 20% into an Erlenmeyer flask containing larvae and distilled water. Calculate the number of deaths at 30 minutes, 1 hour, 2 hours and 3 hours. Results: The results of this study showed larval mortality at a concentration of 5%, namely 0 larvae in 30 minutes, 1 larva in 1 hour, 2 larvae in 2 hours and 3 larvae in 3 hours. Larval mortality at a concentration of 10% is 1 larva in 30 minutes, 2 larvae in 1 hour, 3 larvae in 2 hours and 0 in 3 hours. Larval mortality at a concentration of 15% is 2 larvae in 30 minutes, 3 larvae in 1 hour, 1 larva in 2 hours and 0 larvae in 3 hours. Larval mortality at a concentration of 20% was 3 larvae in 30 minutes, 3 larvae in 1 hour and 0 larvae in 2 and 3 hours. Conclusions: The combination of basil (Ocimum basilicum) and soursop leaf (Annona muricata) leaf extracts is most effective as a larvicide at a concentration of 20% with a death time of 30 minutes.
Co-Authors Amalia, Nabila Angger Putri M. Soleh, Ayu Asista Indarusanti, Delvia Ayu Susanti, Dhina Hariani Nurjanah, Mutia Hayati, Farhatul Hidayati, Sholihatil Imroatul Muflihah, Ahdiah Kalyana Meta, Nilanda Mufidah, Hartalina Salsa Safitri, Avrillia Sandi Basuki, Aditya Occy Shafrina Rohma, Hanna Trianggaluh Fauziah, Dina