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All Journal Quality : Jurnal Kesehatan Prosiding Seminar Nasional Unimus
Afriansyah, M. Ardi
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Humanities Engineering Health Professions Nursing Public Health

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BIOPROSPECT OF BACTERIAL FIBRINOLYTIC PROTEASE FROM BEKASAM OF LONGTAIL TUNA AS ANTITHROMBOTIC AGENT: LITERATURE REVIEW AND BIBLIOGRAPHY STUDY Trianes, Juwy; Ethica, Stalis N.; Afriansyah, M. Ardi; Darmawati, Sri; Rahmani, Nanik; Zilda, Dewi S.
Quality : Jurnal Kesehatan Vol. 18 No. 2 (2024): Quality : Jurnal Kesehatan
Publisher : Politeknik Kesehatan Kemenkes RI Jakarta I

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36082/qjk.v18i2.2016

Abstract

Introduction:Cardiovascular disease (CVD) is the leading cause of death worldwide, with thrombosis being a significant risk factor. Fibrinolytic proteases have potential as antithrombotic agents and could be developed into CVD drugs. Indonesia's traditional fermented products, such as fish Bekasam, are rich in microorganisms, including fibrinolytic protease-producing bacteria, yet their potential for CVD treatment is underexplored. Fish paste in Indonesia serves as a protein source and a reservoir of bacterial diversity, which could aid in discovering new antithrombotic agents. Objective: This literature review examines research trends over the past decade on fibrinolytic protease-producing bacteria in traditional fermented products, with a focus on Bekasam made from Longtail Tuna. This fermented food is an alternative source for obtaining bacteria with antithrombotic properties. Methods: Data for this review were sourced from Google Scholar, PubMed, and the dimension.ai database, using the keyword "bacterial fibrinolytic protease" from 2015 to 2024. Visualization of global research trends was performed using VOS viewer software. Results: The review found a scarcity of studies on fibrinolytic proteases from Bekasam bacteria. Lactic acid bacteria involved in Bekasam fermentation possess proteolytic enzymes that degrade fish protein into peptides and amino acids, potentially offering antithrombotic properties. This suggests natural protease sources from traditional fermented foods have significant biomedical potential. Research on fibrinolytic protease-producing bacteria from Bekasam in Indonesia is limited and requires further development. Exploring these local fermented products could yield innovative sources for thrombosis treatment
Pengaruh Lama Penundaan Spesimen Darah K2EDTA Terhadap Morfologi Leukosit Pada Apusan Darah Tepi Aunisajidah, Noviyani; Afriansyah, M. Ardi
Prosiding Seminar Nasional Unimus Vol 7 (2024): Transformasi Teknologi Menuju Indonesia Sehat dan Pencapaian Sustainable Development G
Publisher : Universitas Muhammadiyah Semarang

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Abstract

Tahap pra- analitik berkontribusi besar sekitar 50-70% dari total kesalahan laboratorium, salah satunyakarena lama penundaan spesimen. Lamanya penundaan spesimen darah K2EDTA dapat mempengaruhihasil pemeriksaan sediaan apusan darah tepi terutama pada morfologi leukosit dimana batas waktupenyimpanan pada suhu ruang hanya 1 jam. Tujuan dari penelitian ini yakni untuk mengetahui pengaruhlama penundaan spesimen darah K2EDTA terhadap morfologi leukosit pada sediaan apusan darah tepi.Jenis penelitian eksperimental. Sampel didapat dengan simple random sampling sebanyak 9 sampel.Analisis data dengan uji chi square. Hasil penelitian didapatkan spesimen darah K2EDTA yang segeradikerjakan pembuatan apusan darah tepi sebanyak 9 preparat (100%) baik yaitu tidak ditemukan kelainanvakuolisasi, piknosis, dan lobulasi nukleus, pada penundaan 2 jam didapatkan 9 preparat (100%) sedangyaitu ditemukannya kelainan vakuolisasi, dan penundaan selama 5 jam didapatkan 9 preparat (100%)sedang yaitu ditemukan vakuolisasi yang semakin membesar. Berdasarkan analisis uji chi square diperolehnilai p value 0.000 (<0.05) hal ini dapat diartikan bahwa terdapat pengaruh penundaan spesimen darahK2EDTA terhadap morfologi leukosit pada sediaan apusan darah tepi. Kata Kunci : Penundaan Spesimen, K2EDTA, Morfologi leukosit, SADT.
Co-Authors Aunisajidah, Noviyani Ethica, Stalis N. NANIK RAHMANI Sri Darmawati Trianes, Juwy Zilda, Dewi S.