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All Journal Jurnal Riset Kesehatan Poltekkes Depkes Bandung Quality : Jurnal Kesehatan
Trianes, Juwy
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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BIOPROSPECT OF BACTERIAL FIBRINOLYTIC PROTEASE FROM BEKASAM OF LONGTAIL TUNA AS ANTITHROMBOTIC AGENT: LITERATURE REVIEW AND BIBLIOGRAPHY STUDY Trianes, Juwy; Ethica, Stalis N.; Afriansyah, M. Ardi; Darmawati, Sri; Rahmani, Nanik; Zilda, Dewi S.
Quality : Jurnal Kesehatan Vol. 18 No. 2 (2024): Quality : Jurnal Kesehatan
Publisher : Politeknik Kesehatan Kemenkes RI Jakarta I

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36082/qjk.v18i2.2016

Abstract

Introduction:Cardiovascular disease (CVD) is the leading cause of death worldwide, with thrombosis being a significant risk factor. Fibrinolytic proteases have potential as antithrombotic agents and could be developed into CVD drugs. Indonesia's traditional fermented products, such as fish Bekasam, are rich in microorganisms, including fibrinolytic protease-producing bacteria, yet their potential for CVD treatment is underexplored. Fish paste in Indonesia serves as a protein source and a reservoir of bacterial diversity, which could aid in discovering new antithrombotic agents. Objective: This literature review examines research trends over the past decade on fibrinolytic protease-producing bacteria in traditional fermented products, with a focus on Bekasam made from Longtail Tuna. This fermented food is an alternative source for obtaining bacteria with antithrombotic properties. Methods: Data for this review were sourced from Google Scholar, PubMed, and the dimension.ai database, using the keyword "bacterial fibrinolytic protease" from 2015 to 2024. Visualization of global research trends was performed using VOS viewer software. Results: The review found a scarcity of studies on fibrinolytic proteases from Bekasam bacteria. Lactic acid bacteria involved in Bekasam fermentation possess proteolytic enzymes that degrade fish protein into peptides and amino acids, potentially offering antithrombotic properties. This suggests natural protease sources from traditional fermented foods have significant biomedical potential. Research on fibrinolytic protease-producing bacteria from Bekasam in Indonesia is limited and requires further development. Exploring these local fermented products could yield innovative sources for thrombosis treatment
THE ROLE OF KOMBUCHA IN HEALTH: BIBLIOMETRICS ANALYSIS Bastian, Bastian; Nurhidayanti, Nurhidayanti; Trianes, Juwy
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 2 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i2.2905

Abstract

Kombucha adalah minuman fermentasi yang secara tradisional dibuat dari teh hijau atau hitam menggunakan kultur simbiotik bakteri dan ragi (SCOBY). Minuman ini telah dikonsumsi secara luas di Asia Timur selama berabad-abad dan kini semakin menarik minat ilmiah global karena potensi manfaat kesehatannya. Studi ini bertujuan untuk menganalisis tren publikasi ilmiah tentang fermentasi kombucha dan aspek kesehatannya melalui pendekatan bibliometrik, guna mengidentifikasi titik panas penelitian dan celah yang perlu dieksplorasi di masa depan. Studi bibliometrik kuantitatif deskriptif dilakukan menggunakan basis data Google Scholar, PubMed, dan Scopus. Kata kunci “fermentasi kombucha” digunakan untuk mengidentifikasi artikel yang diterbitkan antara tahun 2016 dan 2025, menghasilkan 30 publikasi ilmiah. Tren publikasi dan jaringan ko-munculan kata kunci divisualisasikan dan dipetakan menggunakan perangkat lunak VOSviewer. Analisis menunjukkan bahwa penelitian kombucha terutama berfokus pada kandungan probiotiknya, aktivitas antioksidan dan antimikroba, serta produksi senyawa bioaktif seperti polifenol dan asam glukuronat. Senyawa-senyawa ini berkontribusi pada efek pendukung kesehatan, termasuk detoksifikasi hati. Namun, hanya sebagian kecil (kurang dari 20%) dari publikasi yang ditinjau memberikan wawasan rinci tentang mekanisme molekuler atau studi in vivo. Meskipun fermentasi kombucha telah menunjukkan potensi biomedis yang signifikan, studi komprehensif tentang jalur biokimia spesifik, senyawa aktif, dan efek klinisnya masih terbatas, terutama di Indonesia dan negara-negara berkembang lainnya. Oleh karena itu, penelitian di masa depan perlu memperluas cakupan ke penyelidikan molekuler dan klinis untuk memaksimalkan peran kombucha sebagai terapi pendukung inovatif untuk penyakit degeneratif.
Co-Authors Afriansyah, M. Ardi Bastian Bastian Ethica, Stalis N. NANIK RAHMANI Nurhidayanti, Nurhidayanti Sri Darmawati Zilda, Dewi S.