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SCOPING REVIEW: TANTANGAN TRANSPLANTASI GINJAL DI NEGARA BERKEMBANG Reza, Muhammad Alfi; Suweleh, Yasser Zein; Ghiffary, Muamar; Fauzi, Ahmad Nur; Pramanugraha, Randi Satria
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.38280

Transplantasi ginjal merupakan salah satu solusi utama bagi pasien dengan gagal ginjal terminal, namun implementasinya di negara berkembang menghadapi berbagai tantangan besar. Oleh karena itu, penelitian ini bertujuan untuk memetakan dan menganalisis tantangan-tantangan utama dalam transplantasi ginjal di negara berkembang melalui pendekatan scoping review. Pendekatan scoping review digunakan untuk mengidentifikasi, memetakan, dan menganalisis berbagai bukti yang ada terkait dengan transplantasi ginjal di negara berkembang. Proses pencarian dilakukan secara sistematis di beberapa basis data, termasuk PubMed, Scopus, dan Google Scholar, dengan menggunakan kata kunci yang relevan seperti "kidney transplantation in developing countries", "challenges in kidney transplantation", dan "organ donation barriers". Artikel yang diterbitkan antara tahun 2018 hingga 2023 dipilih dan dievaluasi berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil analisis menunjukkan bahwa tantangan medis utama dalam transplantasi ginjal di negara berkembang meliputi keterbatasan fasilitas medis, kurangnya tenaga medis terlatih, serta masalah terkait imunosupresan dan ketidaksesuaian HLA antara donor dan penerima. Tantangan sosial dan budaya juga berperan penting, dengan rendahnya kesadaran masyarakat mengenai pentingnya donor organ dan adanya stigma terkait donor hidup. Secara ekonomi, biaya tinggi untuk prosedur transplantasi dan perawatan pasca-operasi menjadi hambatan utama. Kebijakan yang lemah dan kurangnya regulasi donor organ turut memperburuk situasi ini. Kesimpulan penelitian ini adalah untuk mengatasi tantangan-tantangan tersebut, diperlukan peningkatan fasilitas medis, pelatihan tenaga medis, serta kebijakan yang mendukung donor organ.

A Critical Appraisal of Global Guidelines on Obturator Nerve Block in TURP: Urological and Anesthetic Collaboration: Penilaian Kritis terhadap Pedoman Global tentang Blok Saraf Obturator pada TURP: Kolaborasi Urologi dan Anestesi Supardi, Alif Zulfikar; Reza, Muhammad Alfi; Krisna, Muhammad Sidharta; Wirawan, Nur Surya
Journal of Aafiyah Health Research (JAHR) Vol. 6 No. 1 (2025): JANUARY-JUNE
Publisher : Postgraduate Program in Public Health, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52103/jahr.v6i1.2010

ABSTRACT Background: Obturator nerve block (ONB) is increasingly recognized as a crucial component in transurethral resection of the prostate (TURP) to prevent complications such as the obturator reflex, which can lead to intraoperative risks including bladder perforation. While ONB has been incorporated into various global clinical guidelines, its implementation remains inconsistent. Objective: This study critically examines the role of ONB in TURP by analyzing global guidelines, comparing different ONB techniques, and evaluating the integration of ONB with other surgical modalities to improve patient safety and procedural outcomes. Method: A comprehensive review of literature and clinical guidelines was conducted to assess the effectiveness, safety, and best practices related to ONB in TURP. Key parameters examined include the efficacy of ultrasound-guided ONB, multimodal approaches combining ONB with bipolar energy or laser techniques, and the impact of training programs for anesthesiologists. Results: Global guidelines from major urological and anesthesiology associations recommend ONB as a beneficial but non-mandatory procedure in TURP, particularly for high-risk patients. Evidence suggests that ultrasound-guided ONB improves procedural success rates and reduces complications. The combination of ONB with newer surgical modalities offers enhanced safety, and structured training programs can further facilitate its adoption in clinical practice. Conclusion: Although ONB is not universally required for TURP, its application significantly improves intraoperative safety. Standardizing protocols, expanding training programs, and integrating ONB with advanced surgical techniques can enhance the efficacy and reliability of TURP globally. Future research should focus on long-term outcomes and cost-effectiveness to refine clinical recommendations.

Impact of Head and Neck Radiotherapy on Perioperative Airway Management in Urological Surgeries: An Anesthetic and Vascular Perspective: Dampak Radioterapi Kepala dan Leher terhadap Manajemen Jalan Napas Perioperatif pada Bedah Urologi: Perspektif Anestesi dan Vaskular Ghiffary, Muamar; Reza, Muhammad Alfi; Sayati, Muhammad Satir; Awaluddin, Muhammad; Fauzi, Ahmad Nur
Journal of Aafiyah Health Research (JAHR) Vol. 6 No. 1 (2025): JANUARY-JUNE
Publisher : Postgraduate Program in Public Health, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52103/jahr.v6i2.2026

ABSTRACT Background: Radiotherapy is a primary treatment for various types of cancer, but it can cause long-term complications, including tissue fibrosis, vascular stenosis, and urological dysfunction. These effects influence anesthetic strategies, surgical technique selection, and postoperative management. Objective: This study aims to compare the effectiveness of endovascular techniques and open vascular reconstruction in managing post-radiotherapy vascular complications, as well as to evaluate the anesthetic and urological implications of radiation-induced tissue fibrosis. Method: This study reviews literature and clinical data on the effects of radiotherapy on the vascular system, airway, and urological system. The comparison between endovascular techniques and open vascular reconstruction is analyzed based on effectiveness, complication risks, and durability. Results: Endovascular techniques offer a minimally invasive approach with faster recovery but carry a higher risk of restenosis compared to open vascular reconstruction, which provides better long-term outcomes despite greater perioperative complications. In patients with post-radiotherapy fibrosis, carotid artery and jugular vein stenosis increase the risk of stroke, while radiation-induced urethral strictures require reconstructive approaches tailored to severity. In anesthesiology, patients with airway changes due to fibrosis are more safely managed with regional anesthesia and multimodal analgesia techniques. Conclusion: The management of post-radiotherapy patients requires a multidisciplinary approach involving anesthesiology, interventional radiology, urology, and vascular surgery specialists. Combining minimally invasive techniques with more aggressive reconstructive strategies can improve clinical outcomes in patients with vascular and urological complications resulting from radiotherapy.

The Role of Clusterin (CLU) in the Pathogenesis of Benign Prostatic Hyperplasia: Mechanisms and Potential as a Biomarker: Peran Clusterin (CLU) dalam Patogenesis Hiperplasia Prostat Jinak: Mekanisme dan Potensi sebagai Biomarker Reza, Muhammad Alfi; Krisna, Muhammad Sidharta; Diennillah, Fathannia Rizky; Putri, Jihan Asma; Yulianto, Andy
Journal of Aafiyah Health Research (JAHR) Vol. 5 No. 1 (2024): JANUARY-JUNE
Publisher : Postgraduate Program in Public Health, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52103/jahr.v5i1.2036

ABSTRACT Background: Benign Prostatic Hyperplasia (BPH) is a common urological condition characterized by excessive proliferation of prostate epithelial and stromal cells, leading to lower urinary tract symptoms. Clusterin (CLU), a multifunctional glycoprotein, has been implicated in various cellular processes, including apoptosis regulation, inflammation, and autophagy. However, its exact role in BPH pathogenesis remains unclear. Objective: This study aims to analyze the role of CLU in the molecular mechanisms underlying BPH and evaluate its potential as a biomarker for disease progression. Method: A comprehensive analysis of recent literature was conducted to examine CLU expression in BPH tissues and its interactions with inflammatory pathways, hormonal regulation, and cellular homeostasis mechanisms such as apoptosis and autophagy. The study also reviewed CLU’s involvement in epithelial-stromal interactions and its correlation with disease severity. Results: Increased CLU expression in hyperplastic prostate tissues is associated with chronic inflammation, contributing to aberrant cell proliferation and apoptosis resistance. CLU interacts with inflammatory markers such as TNF-α and IL-6, promoting a microenvironment conducive to disease progression. Additionally, CLU is involved in autophagy dysregulation, which may further sustain cellular survival and resistance to apoptosis. Evidence suggests that hormonal factors, particularly androgens and estrogens, regulate CLU expression, linking it to prostate tissue remodeling. These findings highlight CLU as a potential biomarker for assessing BPH severity and progression. Conclusion: CLU plays a critical role in BPH pathogenesis by modulating inflammatory responses, apoptosis, and cellular homeostasis. Its increased expression in hyperplastic prostate tissues suggests that it may serve as a novel biomarker for disease progression. However, further studies are needed to validate its clinical applicability and explore targeted therapies aimed at CLU modulation to improve BPH management.

The Long-Term Urological Consequences of Anabolic Steroid Abuse: A Narrative Review: Konsekuensi Urologi Jangka Panjang dari Penyalahgunaan Steroid Anabolik: Sebuah Narasi Reza, Muhammad Alfi; Krisna, Muhammad Sidharta; Diennillah, Fathannia Rizky; S. , Suriani; Yulianto, Andy
Journal of Aafiyah Health Research (JAHR) Vol. 5 No. 2 (2024): JULY-DECEMBER
Publisher : Postgraduate Program in Public Health, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52103/jahr.v5i2.2037

ABSTRACT Background: Anabolic-Androgenic Steroids (AAS) have been widely used to enhance muscle mass and physical performance. However, their prolonged use has been associated with various adverse effects on urological health, including hypogonadism, infertility, erectile dysfunction (ED), and benign prostatic hyperplasia (BPH). Suppression of the hypothalamic-pituitary-gonadal (HPG) axis due to AAS leads to significant hormonal imbalances and long-term reproductive consequences. Objective: This study aims to review the urological effects of AAS, focusing on their impact on testosterone levels, spermatogenesis, erectile function, and prostate health. The review highlights potential risks and clinical implications for individuals using AAS. Method: A narrative review was conducted by analyzing relevant studies from PubMed, Scopus, and Science Direct published between 2014-2024. Articles were selected based on their relevance to the impact of AAS on urological health, particularly hypogonadism, infertility, ED, and BPH. Data from clinical trials, cohort studies, and systematic reviews were synthesized to provide a comprehensive analysis. Results: Chronic AAS use significantly reduces endogenous testosterone production, leading to hypogonadism and associated symptoms such as fatigue, decreased libido, and mood disturbances. Studies indicate a strong correlation between AAS use and impaired spermatogenesis, with some cases resulting in irreversible infertility. Moreover, AAS users have a higher prevalence of ED compared to non-users due to hormonal imbalances and psychological factors. Excessive androgen stimulation is also linked to an increased risk of prostate enlargement, potentially leading to urinary complications. Conclusion: The long-term use of AAS poses substantial risks to urological health, necessitating awareness and early intervention. Regular medical monitoring and cessation strategies are essential to mitigate these adverse effects. Further research is needed to develop effective rehabilitation and treatment options for individuals experiencing AAS-related urological complications.

Analisis Faktor Risiko Infeksi Saluran Kemih (ISK) Berdasarkan Diagnosis Dokter Umum di Puskesmas Tanralili Maros Tahun 2022-2023: Studi Retrospektif Cross Sectional: Analysis of Risk Factors for Urinary Tract Infection (UTI) Based on General Practitioner Diagnosis at the Tanralili Maros Community Health Center in 2022-2023: Retrospective Cross Sectional Study Reza, Muhammad Alfi; Diennillah, Fathannia Rizky
Journal of Aafiyah Health Research (JAHR) Vol. 5 No. 1 (2024): JANUARY-JUNE
Publisher : Postgraduate Program in Public Health, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52103/jahr.v4i1.1711

Abstract Background: Urinary Tract Infection (UTI) is a clinical condition in the urinary tract where there are bacteria in the urine caused by microorganisms that have the potential to enter the urinary tract. Urinary Tract Infections (UTI) often cause morbidity and can result in significant mortality. Although the urinary tract is normally free from bacterial growth, bacteria that generally rise from the rectum can cause UTIs. Aim: This study aims to explore the risk factors that influence the incidence of Urinary Tract Infections (UTI) at the Puskesmas Tanralili Maros. Methods: This research uses a cross-sectional retrospective descriptive method using total population sampling technique. Data was obtained through medical records for the 2022-2023 period at the Puskesmas Tanralili Maros and 96 medical records were obtained that were diagnosed with UTI by the general practitioner at the Community Health Center. Data processing was carried out using Microsoft Excel in 2016. Results: The results showed that the prevalence of UTI sufferers in 2022 was 8 people (39.58%) and in 2023 there was an increase of 58 people (60.42%). The highest prevalence of UTI was in the 26-45 year age range, 39 people (40.63%), and the lowest prevalence was in the <5 year age range, 1 person (1.04%). The highest prevalence of UTI was found in women as many as 69 people (71.88%) and in male patients as many as 27 people (28.13%). The highest prevalence of UTI in the education category was SMA (Senior High School), namely 38 people (39.58%), and the lowest prevalence was S2, 1 person (1.04%). The highest prevalence of UTI based on marital status was married patients, namely 73 people (76.04%) and the lowest prevalence was those with divorced status, 3 people (3.13%). The highest prevalence of UTI based on the occupation of housewives is the highest prevalence, namely 44 people (45.83), and the lowest prevalence of employment is not working, TNI and Police, namely 1 person each (1.04%) Conclusion: The prevalence of UTI sufferers in 2023 will increase compared to the previous year. The highest prevalence of UTI occurs in the age range 26-45, gender is female, education category is SMA (Senior High School), based on marital status is a married patient, based on occupation is a housewife

Isu Terkini Euthanasia Antara Hak Hidup dan Hak Menentukan Pilihan: Systematic Literature Review: Current Issues in Euthanasia Between the Right to Life and the Right to Choose: A Systematic Literature Review Reza, Muhammad Alfi; Diennillah, Fathannia Rizky
Journal of Aafiyah Health Research (JAHR) Vol. 4 No. 1 (2023): JANUARY-JUNE
Publisher : Postgraduate Program in Public Health, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52103/jahr.v4i1.1712

Abstract Background: Euthanasia up to now, there are still no regulations or regulations that are legally implemented and apply in Indonesia, including criminal responsibility for the perpetrator or family who wants euthanasia. Currently, euthanasia is discussed more often and is equated with the action of a doctor or health worker who carries out the act or act of injecting a patient to death at the request of the patient himself or at the request of the victim's family. There are various opinions about the pros and cons of euthanasia, including being faced with two difficult choices, namely the right to life and the right to make choices. Aim: This research aims to explore the act of euthanasia, both active and passive, along with ethical and moral dilemmas Method: The method used in this writing is a literature review which is a systematic, explicit and reproducible method for identifying, evaluating and synthesizing research works and ideas that have been produced by researchers and practitioners. Results: The research results show that euthanasia is an ethical and moral dilemma in the code of ethics of health professionals because they are faced with a difficult choice between complying or not complying with requests from the patient/family directly and indirectly. Passive euthanasia is still ethically acceptable with several considerations, but active euthanasia is opposed to being carried out on ethical, moral and legal grounds. The right to life must not be revoked arbitrarily or "arbitrarily deprived" which is implemented by limiting the scope of this right, and therefore it is the state's duty to ensure the right to life. Countries that allow euthanasia must provide effective safety procedures so that it is not used as an abuse. Conclusion: Euthanasia is an ethical and moral dilemma in the code of ethics for health professionals because they are faced with a difficult choice between complying or not complying with requests from the patient/family directly and indirectly. Passive euthanasia is still ethically acceptable with several considerations, but active euthanasia is opposed on ethical, moral and legal grounds.

CHARACTERISTICS OF PATIENTS WITH SUSPECTED BENIGN PROSTATIC HYPERPLASIA BASED ON AGE, OCCUPATION, AND EDUCATION LEVEL AT THE PUSKESMAS TANRALILI MAROS 2022-2023 PERIOD : A RETROSPECTIVE CROSS-SECTIONAL STUDY Reza, Muhammad Alfi; Diennillah, Fathannia Rizky
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.26003

Benign prostatic hyperplasia (BPH) adalah diagnosis histologis yang mengacu pada proliferasi jaringan epitel dan otot polos di dalam zona transisi prostat. BPH sering menyebabkan disfungsi pada saluran kemih bagian bawah pria dan paling sering terjadi pada pria lanjut usia. Sekitar 18-25% pria berusia di atas 40 tahun dan lebih dari 90% pria di atas 80 tahun mengalami BPH. Penelitian ini menggunakan metode deskriptif retrospektif cross-sectional dengan menggunakan teknik total populasi sampling. Data diperoleh melalui rekam medis periode 2022-2023 di Puskesmas Tanralili dan diperoleh 21 rekam medis yang didiagnosis suspek BPH oleh Dokter Umum di Puskesmas Tanralili. Pengolahan data dilakukan dengan menggunakan Microsoft Excel 2016. Hasil penelitian menunjukkan prevalensi BPH pada tahun 2022 sebanyak 9 pasien (42,85%) dan pada tahun 2023 terjadi peningkatan sebanyak 12 pasien (57,14%). Disimpulkan bahwa prevalensi BPH tertinggi pada rentang usia 60-69 tahun sebanyak 10 pasien (47,61%), dan prevalensi terendah pada rentang usia 40-49 tahun sebanyak 3 pasien (14,28%). Prevalensi BPH tertinggi pada kategori pekerjaan adalah petani sebanyak 13 pasien (61,90%) dan prevalensi terendah masing-masing 1 pasien adalah pensiunan, TNI/POLRI, dan PNS (4,76%). Prevalensi BPH tertinggi pada kategori tingkat pendidikan adalah SD sebanyak 12 pasien (57,14%) dan terendah pada ? D3 sebanyak 1 pasien (4,76%).

PERAN KAFEIN PADA KOPI DAN TEH SEBAGAI ALTERNATIF PENCEGAHAN PENYAKIT KARSINOMA KULIT NON-MELANOMA : SEBUAH LITERATUR REVIEW Reza, Muhammad Alfi; Diennillah, Fathannia Rizky
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.26084

Insiden kanker kulit meningkat di seluruh dunia, sebagai akibat dari paparan sinar matahari kronis, perubahan iklim dan kondisi individu dan sosial. Secara keseluruhan, kanker kulit termasuk cutaneous melanoma (CM) dan non-melanoma skin cancer (NMSC) yang terutama diwakili oleh karsinoma sel basal (BCC) dan karsinoma sel skuamosa (SCC). Metode yang digunakan dalam penulisan ini adalah literatur review yang merupakan metode secara sistematis, eksplisit dan reprodusibel untuk melakukan identifikasi, evaluasi dan sintesis terhadap karya - karya hasil penelitian dan hasil pemikiran yang sudah dihasilkan oleh para peneliti dan praktisi. Hasil penelitian menunjukkan aplikasi topikal kafein atau kafein natrium benzoat 0,5 jam sebelum penyinaran UVB menghambat pembentukan dimer timin yang diinduksi UVB dan menghambat lesi kulit terbakar akibat sinar matahari yang diinduksi UVB, dan kafein natrium benzoat lebih efektif daripada kafein. Analisis meta ini terdiri dari jumlah penelitian terbesar dibandingkan dengan meta-analisis sebelumnya. Temuan utama adalah penurunan risiko 22% dari ketiga jenis kanker kulit dengan asupan kopi berkafein. Hubungan ini tidak terjadi pada kopi tanpa kafein. Meta analisis lainnya tidak menemukan hubungan yang signifikan antara teh dan kanker kulit, tetapi menurut hasil penelitan tersebut, teh mengalami penurunan sebesar 15 risiko kanker kulit. Hasil ini masuk akal karena kandungan kafein relatif teh sekitar setengah dari kopi. Penurunan risiko BCC, SCC, NMSC, dan melanoma dengan asupan kafein total masing-masing adalah 12%, 23%, 23%, dan 19%. Dengan menggunakan data ini, ditemukan bahwa jumlah kanker kulit dapat dicegah dan penghematan biaya setiap tahun menjadi signifikan.

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