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The Role of Transforming Growth Factor-Beta, Fibroblast Growth Factor, Platelet-derived Growth Factor, Epidermal Growth Factor, Insulin-like Growth Factor, Vascular Endothelial Growth Factor, and Sonic Hedgehog in the Non-syndromic cleft lip with or without cleft palate development: A Scoping Review Ullah, Irfan; Khan, Muhammad Salman; Nasroen, Saskia Lenggogeni; Maskoen, Ani Melani; Sarilita, Erli
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.51493

Non-syndromic cleft lip with or without cleft palate (NSCLP) birth defect, it imposes an enormous stress on society and requires nutrition, dental, speech, behavioural, and surgical therapies. The NSCLP multifactorial aetiology, including the environment and genetic factors. The environment and genetic factors affect the cellular mechanism, cell proliferation, cell differentiation, and cell migration and signalling pathways. Genetic growth factors including Transforming Growth Factor-Beta (TGF-β), Fibroblast Growth factors (FGFs), Platelet-derived Growth factors (PDGFs), Epidermal Growth factor (EGF), Insulin-like growth factors (IGF), Vascular Endothelial Growth factor (VEGF), Sonic Hedgehog (SHH). The study aims to understand the role of the growth factors “TGF-β, FGFs, PDGFs, EGF, IGF, VEGF, and SHH” in NSCLP development. Preferential Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standards were followed when performing this scoping review. The 942 articles were extracted, and the following inclusion and exclusive criteria 43 articles were eligible for review. Twenty-seven studies identify 26 genes and 25 single-nucleotide polymorphisms (SNPs)/variants of the growth factors that are a significant risk for NSCLP development. In conclusion, the analysis of diverse populations and growth factors including TGF-β, FGFs, PDGFs, EGF, IGF, VEGF, and SHH were associated with NSCLP. The growth factors were involved in the cellular mechanism, cell proliferation, cell differentiation cell migration and signalling pathways that lead to the pathogenesis of NSCLP.

Age estimation of ancient skeletons based on the molar teeth attrition Ramadhani, Triane Ayu; Sarilita, Erli; Malinda, Yuti; Yondri, Lutfi; Cunningham, Craig A; Oscandar, Fahmi
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.222-230

Background: Two ancient skeletons (Subang Men) were excavated at the Subanglarang site, Subang Regency, West Java, Indonesia. The partial jaw containing set of teeth from the two skeletons was examined to determine the level of dental attrition present which was then used to estimate age at death.Objective: The aim of this study was therefore to determine the pattern of attrition on the molar teeth and use this to estimate the age at death of the Subang Men.Methods: The pattern of attrition in each cusp of the first molar (M1) and second molar (M2) was examined clinically and then compared with the Average Stage of Attrition (ASA) method. Estimated age was then estimated using formula that are outlined in the Average Stage of Attrition (ASA) method.Results: The results showed that the level of attrition that occurred in the M1 and M2 teeth of the two ancient man was significant. The estimated age at death calculated based on the attrition pattern of molar teeth for skeleton 1 was 38.9 and skeleton 2 was 61.9-64.6.Conclusion: Dental attrition which is caused by physiologic and pathologic teeth friction is related to age. Therefore, age estimation can be determined based on the attrition pattern that occurs in the teeth.

Age estimation of ancient skeletons based on the molar teeth attrition Ramadhani, Triane Ayu; Sarilita, Erli; Malinda, Yuti; Yondri, Lutfi; Cunningham, Craig A; Oscandar, Fahmi
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.222-230

Background: Two ancient skeletons (Subang Men) were excavated at the Subanglarang site, Subang Regency, West Java, Indonesia. The partial jaw containing set of teeth from the two skeletons was examined to determine the level of dental attrition present which was then used to estimate age at death.Objective: The aim of this study was therefore to determine the pattern of attrition on the molar teeth and use this to estimate the age at death of the Subang Men.Methods: The pattern of attrition in each cusp of the first molar (M1) and second molar (M2) was examined clinically and then compared with the Average Stage of Attrition (ASA) method. Estimated age was then estimated using formula that are outlined in the Average Stage of Attrition (ASA) method.Results: The results showed that the level of attrition that occurred in the M1 and M2 teeth of the two ancient man was significant. The estimated age at death calculated based on the attrition pattern of molar teeth for skeleton 1 was 38.9 and skeleton 2 was 61.9-64.6.Conclusion: Dental attrition which is caused by physiologic and pathologic teeth friction is related to age. Therefore, age estimation can be determined based on the attrition pattern that occurs in the teeth.

Developing collaborative strategies to address challenges and leverage opportunities in traditional arts digital preservation Rafianti, Laina; Khadijah, Ute Lies Siti; Sarilita, Erli; Martina, Martina; Juliandri, Arfan
Jurnal Informatio Vol 6, No 1 (2026): 2026
Publisher : Faculty of Communication, Padjadjaran University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/inf.v6i1.68333

Background: The rapid advancement of digital technologies has transformed how cultural heritage is preserved, accessed, and disseminated. While digitalization offers new opportunities to revitalize traditional arts and engage younger generations, it raises concerns related to cultural authenticity, technical capacity, and ethical governance.Purpose: This study examines (1) how digital technologies contribute to the preservation and revitalization of traditional arts, (2) the key challenges faced by artists and cultural practitioners in adapting to digital environments, and (3) the collaborative strategies required to ensure culturally grounded and sustainable digitalization. Methods: A qualitative approach was employed using semi-structured interviews with five informants, including traditional artists, academics, and cultural practitioners involved in heritage-related activities in Indonesia. Data were analyzed thematically to identify recurring patterns related to digital preservation practices, challenges, and forms of collaboration.Results: Findings show that digitalization strengthens preservation by expanding accessibility, protecting fragile archives, and creating immersive experiences through technologies such as virtual reality and digital platforms. However, informants highlight significant constraints, including digital literacy gaps, inadequate infrastructure, financial barriers, and intellectual property risks. They emphasize that authentic cultural values must remain central in digital transformation. Effective digitalization requires multi-stakeholder collaboration—linking artists, communities, academics, government, and technology actors to ensure accuracy, cultural integrity, and sustainable implementation. Conclusions: Digital technologies hold meaningful potential for revitalizing traditional arts when applied ethically and collaboratively. Sustainable digital preservation requires culturally sensitive approaches, institutional support, and coordinated multi-stakeholder engagement. Future research should involve broader participant groups and comparative cultural contexts to deepen understanding of long-term digital preservation strategies.

Geometric Morphometric Analysis in Human Craniofacial Research: Diagnostic Value and Clinical Implications – A Systematic Review Sovira, Gita Dwi Jiwanda; Sarilita, Erli
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Background: Geometric morphometric analysis has become an essential quantitative approach for evaluating complex craniofacial morphology beyond traditional linear measurements. Advances in three-dimensional imaging have expanded its application in diagnosis, treatment planning, and outcome assessment in craniofacial and dental practice. However, a comprehensive synthesis of its clinical relevance remains limited. Method: This systematic review was conducted in accordance with PRISMA 2020 guidelines. Literature searches were performed in PubMed, Scopus, and Google Scholar for articles published between 2019 and 2024. Eligible studies included original research involving human subjects that applied geometric morphometric analysis to craniofacial structures with reported diagnostic or therapeutic relevance. Study selection, data extraction, and qualitative synthesis were performed independently. Results: Eight studies met the inclusion criteria. The findings demonstrated that geometric morphometrics is widely applied in odontological analysis and orthognathic surgery. Applications in forensic and anthropological research further highlighted its utility in population and individual identification. Conclusion: Geometric morphometric analysis provides a objective framework for craniofacial diagnosis and treatment planning. Its integration with three-dimensional imaging technologies enhances diagnostic accuracy and supports data-driven clinical decision-making. Future studies should focus on protocol standardization and large-scale clinical validation to facilitate broader implementation in routine practice.

The Effectiveness of Omega-3 Fatty Acid Supplementation in the Management of Periodontal Disease in Patients with Type 2 Diabetes Mellitus Rafisa, Anggun; Dewi Marhaeni Diah Herawati; Tjahajawati, Sri; Sarilita, Erli
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Type 2 diabetes mellitus is closely associated with periodontitis through chronic inflammation and impaired tissue healing, resulting in a bidirectional relationship that adversely affects both metabolic control and periodontal health. Omega-3 fatty acids possess anti-inflammatory and pro-resolving properties and have been proposed as adjunctive host-modulatory agents in periodontal therapy for patients with diabates. This systematic review aimed to evaluate the effectiveness of omega-3 fatty acid supplementation, alone or in combination with other adjunctive therapies, on periodontal and systemic outcomes in patients with periodontitis and type 2 diabetes mellitus. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted in PubMed and Scopus databases for randomized controlled trials published between 2015 and 2025. Eligible studies investigated omega-3 fatty acid supplementation as an adjunct to nonsurgical periodontal therapy in patients with periodontitis and diabetes mellitus. Data were extracted and synthesized descriptively. Six randomized controlled trials met the inclusion criteria. Adjunctive omega-3 fatty acid supplementation consistently demonstrated greater improvements in periodontal parameters, including probing depth, clinical attachment level, and gingival inflammation, compared with nonsurgical periodontal therapy alone. Omega-3–based interventions were associated with significant reductions in inflammatory and cardiometabolic biomarkers, such as interleukins, pentraxin, chemerin, malondialdehyde, and glycated hemoglobin. Combined interventions, particularly omega-3 with low-dose aspirin or omega-3–enriched cranberry juice, yielded the most pronounced periodontal and metabolic benefits. Omega-3 fatty acids appear to be a promising adjunctive therapy for improving periodontal and systemic outcomes in patients with type 2 diabetes mellitus.

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