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Effect of Moringa Leaf Infusion (Moringa oleifera) on Reducing Blood Glucose and Total Cholesterol Levels in Mice (Mus musculus) with Diabetic Ulcers Napitupulu, Helen Debora; Siahaan, Jekson Martiar; Simangunsong, Batara
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.799

Background: Diabetes mellitus is a chronic disease in the form of metabolic disorders, which is characterized by blood glucose levels (KGD) that exceed normal limits and are accompanied by impaired metabolism of carbohydrates, lipids, and proteins, as a result of abnormalities in insulin secretion. Diabetics are known to have slow wound healing. Moringa oleifera leaves or moringa plants contain flavonoid compounds, which can decrease glucose absorption. This study aims to determine the effect of moringa leaf infusion on blood sugar levels, glucose tolerance, cholesterol levels, body weight, and wound healing speed in mouse model animals. Subject and Method: This study is experimental using a posttest only controlled group design, using 25 male mice (Mus musculus) divided into 5 groups. The study was conducted at the Phytochemistry and Animal House Laboratory, Faculty of Medicine, Methodist University Indonesia from March to May 2022. The bound variables were body weight measured using a scale, current blood glucose levels and blood glucose levels with glucose loading measured with strips and glucometers, total cholesterol levels measured using strips and cholesterol measuring devices, and the length of mice wounds measured using a ruler. The free variable is the variation in the dose of moringa leaf infusion. The data were analyzed using the Anova and Kruskal-Wallis tests. Results: The administration of moringa leaf infusion had a significant effect on the reduction of the levels of each variable, namely a dose of 10% in body weight, a dose of 30% in KGD, 20% in KGD with glucose loading, 20% in cholesterol, and 20% in wound closure, which was proven based on the results of statistical tests. Conclusion: Moringa leaf infusion can lower blood sugar levels, blood sugar levels by glucose depletion, cholesterol levels, body weight, and accelerate wound healing in sucrose-induced mice, high fat diet, and PTU.

PENYULUHAN PENCEGAHAN STUNTING PADA ANAK DI SD NEGERI 060919 Tarigan, Juliyanti; Syahrir, Lesmana; Tiji, Wijaya Taufik; Simangunsong, Batara; Pasaribu, Sumihar M.R.; Gea, Melfan J.; Harianja, Ester G.; Tampubolon, Gelberd V.M.; Simalango, Penina T.; Ginting, Lucky A.B.; Sibuea, Charina T.Y.; Pangaribuan, Megaria Evhiphanias; Simanullang, Yolanda K.H.R.; Ginting, Mischkel A.; Meha, Panahian M.
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 3 No 2 (2023): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol3No2.pp208-211

Stunting is a situation where a child's height is stunted compared to the height of children his age. In Indonesia, stunting is a problem in the health sector that is still high. This condition occurs because children are malnourished for a long time with signs of failure in the child's growth and development (growth faltering) which starts from pregnancy until the child is 2 years old. This is the formulation of our problem in holding outreach activities on the topic of Stunting at SD Negeri 060919, Kec. Medan Sunggal, Medan city. This article was created with the aim of providing education and information regarding stunting prevention. Thus, this activity is very useful in providing information about how to prevent and reduce the incidence of stunting. It is hoped that this activity will be carried out at SD Negeri 060919, Kec. Medan Sunggal, Medan City to pay more attention to the nutritional intake of mothers and children, so that the incidence of stunting in Indonesia is reduced.

PENYULUHAN PENCEGAHAN STUNTING PADA ANAK DI SD NEGERI 060919 Tarigan, Juliyanti; Syahrir, Lesmana; Tiji, Wijaya Taufik; Simangunsong, Batara; Pasaribu, Sumihar M.R.; Gea, Melfan J.; Harianja, Ester G.; Tampubolon, Gelberd V.M.; Simalango, Penina T.; Ginting, Lucky A.B.; Sibuea, Charina T.Y.; Pangaribuan, Megaria Evhiphanias; Simanullang, Yolanda K.H.R.; Ginting, Mischkel A.; Meha, Panahian M.
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 3 No 2 (2023): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol3No2.pp208-211

Stunting is a situation where a child's height is stunted compared to the height of children his age. In Indonesia, stunting is a problem in the health sector that is still high. This condition occurs because children are malnourished for a long time with signs of failure in the child's growth and development (growth faltering) which starts from pregnancy until the child is 2 years old. This is the formulation of our problem in holding outreach activities on the topic of Stunting at SD Negeri 060919, Kec. Medan Sunggal, Medan city. This article was created with the aim of providing education and information regarding stunting prevention. Thus, this activity is very useful in providing information about how to prevent and reduce the incidence of stunting. It is hoped that this activity will be carried out at SD Negeri 060919, Kec. Medan Sunggal, Medan City to pay more attention to the nutritional intake of mothers and children, so that the incidence of stunting in Indonesia is reduced.

Pengaruh Infusa Daun Kelor (Moringa oleifera) terhadap Penurunan Kadar Glukosa Darah dan Kolesterol Total pada Mencit (Mus musculus) yang Mengalami Ulkus Diabetikum: Pengaruh Infusa Daun Kelor (Moringa oleifera) Napitupulu, Helen Debora; Siahaan, Jekson Martiar; Simangunsong, Batara
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1671

Background: Diabetes mellitus is a chronic disease in the form of metabolic disorders, which is characterized by blood glucose levels (BGL) that exceed normal limits and are accompanied by disorders of carbohydrate, lipid, and protein metabolism, as a result of abnormalities in insulin secretion. Diabetics are known to have slow wound healing. Moringa oleifera leaves contain flavonoid compounds, which can reduce glucose absorption. Objective: This study aims to determine the effect of Moringa leaf infusion on blood sugar levels, glucose tolerance, cholesterol levels, body weight, and speed of wound healing in mice model. Method : A total of 25 male mice aged 2-3 months weighing 25-30 grams were divided into 5 experimental groups namely: negative control, positive control, 10% Moringa infusion, 20% infusion, 30% infusion. The negative control was not given any treatment. Positive controls were induced by high fat diet and PTU and given sucrose for 3 weeks. The infusion group was the same as the positive control but at the end of each week, 10%, 20%, and 30% Moringa leaf infusion were given successively. Moringa leaf intervention was given for 3 weeks after feed induction and observations were made at that range. The wound was made after feeding induction on the back 1 cm long. Result : Moringa leaf infusion had a significant effect on reducing the levels of each variable, namely a dose of 10% on body weight, a dose of 30% on KGD, 20% on KGD with glucose loading, 20% on cholesterol, and 20% on wound closure, which proved based on the results of statistical tests. Conclusion: Moringa leaf infusion can reduce blood sugar levels, blood sugar levels by loading glucose, cholesterol levels, body weight, and accelerate wound healing in mice induced by sucrose, high fat diet, and PTU.

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