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All Journal Indonesian Journal of Pharmaceutical Science and Technology Cakradonya Dental Journal
Sastradipura, Dewi Fatma Suniarti
Unknown Affiliation
Computer Science & IT Dentistry Medicine & Pharmacology Public Health

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The Role of Veillonella in The Pathogenesis of Periodontitis: Systematic Review Rohmah, Devi Kartika; Soekanto, Sri Angky; Djais, Ariadna Adisattya; Theodorea, Citra Fragrantia; Sastradipura, Dewi Fatma Suniarti
Cakradonya Dental Journal Vol 17, No 2 (2025): Agustus 2025
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v17i2.43973

Abstract

Veillonella is a common species found in the human oral cavity that plays a significant role in biofilm ecology. Veillonella is known to play a supporting role in colonizing other, more pathogenic species. Its abundant presence in supra- and sub-gingival biofilms is thought to have an associated relationship with red-complex bacterial species. These bacteria are known to be the causative of periodontal disease. Their ability to establish this mutualistic relationship is an important factor that we need to know to expand our understanding of their relationship to the pathogenesis of periodontal disease and to develop more effective treatments.
Mapping the Anticancer Mechanism of Asiatic Acid : A systematic review of preclinical evidence Sari, Rina Kartika; Dalimunthe, Rahmi Syaflida; Amir, Lisa Rinanda; Wimardhani, Yuniardini Septorini; Musfiroh, Ida; Sastradipura, Dewi Fatma Suniarti
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62028

Abstract

Studies have demonstrated that Asiatic acid (AA) from Centella asiatica has anticancer properties in cancer cell lines, but translating these findings into clinical research remains challenging. This review aims to provide a robust scientific foundation for enhancing the translational potential of AA-based anticancer therapy. The PubMed, Scopus, and ScienceDirect databases were searched electronically using specific keywords and screened in accordance with the PRISMA 2020 guidelines.  Fourteen studies meet the criteria. All research was conducted in vitro; four studies were conducted both in vitro and in vivo, and three were conducted in silico.Asiatic acid (AA) demonstrates potent anticancer activity by modulating key signaling pathways, including PI3K/Akt and NF-κB, thereby inhibiting proliferation, promoting apoptosis, and reducing metastasis. Its cytotoxic effects are time- and dose-dependent (1–50 µM) and minimal in normal cells. While AA and its derivatives consistently outperform controls, limitations such as missing control dose data warrant further investigation. Future studies should focus on in vivo validation, clinical translation, and advanced strategies such as targeted delivery and AI-assisted drug development to fully realize AA’s therapeutic potential.
Co-Authors Amir, Lisa Rinanda Dalimunthe, Rahmi Syaflida Djais, Ariadna Adisattya Ida Musfiroh -, Ida Musfiroh Rohmah, Devi Kartika Sari, Rina Kartika Sri Angky Soekanto Theodorea, Citra Fragrantia Yuniardini Septorini Wimardhani