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All Journal Journal of Health Science and Medical Therapy WASATHON Medicor : Journal of Health Informatics and Health Policy Brawijaya Journal of Urology
Syuaib, Achmad
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Humanities Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Antimalarial Activity of Brown Alga Extract Sargassum sp on Liver Cell of Mouse (Mus musculus) Infected with Plasmodium berghei Ukratalo, Abdul M; Syuaib, Achmad; Pangemanan, Victory O; Embisa, Yushar A; Kaliky, Arief Rahman S; Loilatu, Muhammad Fitrah
Journal of Health Science and Medical Therapy Том 3 № 01 (2025): Journal of Health Science and Medical Therapy
Publisher : PT. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/jhsmt.v3i01.1313

Abstract

Sargassum sp is rich in steroid, alkaloid, phenol, flavonoid, saponin, and tannin components, which have anti-malarial and immunomodulatory properties. This study aimed to assess the anti-malarial effects of an extract from brown algae Sargassum sp on liver cells in Plasmodium berghei-infected house mouse (Mus musculus). Twenty to thirty-gramme house mice were infected with Plasmodium berghei at a dosage of 0.1 ml per tail and monitored until the parasitemia level reached 1-5%. Subsequently, house mice (Mus musculus) were administered methanol extract of brown algae Sargassum sp at 10, 100, and 200 mg/g BW doses for four consecutive days, from day 0 to day 6. On day 6, surgery was performed to extract the liver organ and prepare histological preparations. The findings demonstrated that applying Sargassum sp extract effectively improved the restoration of liver damage in house mice infected with Plasmodium berghei.
Pometia pinnata Leaf Extract As a Natural Larvicide For aedes aegypti Mosquitoes, A Vector Of Dengue Haemorrhagic Fever (DHF) Disease Ukratalo, Abdul M; Manery, Dodikrisno E; Syuaib, Achmad; Muhammad, Alfaro; Nanere, Bill E; Assagaf, Abdur Rahman
Medicor : Journal of Health Informatics and Health Policy Vol. 2 No. 1 (2024): January 2024
Publisher : Indonesian Scientific Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61978/medicor.v2i1.200

Abstract

Dengue Haemorrhagic Fever (DHF) is a rapid-onset infection caused by the Dengue virus that can lead to severe shock and even death. Pometia pinnata, a plant found in the Maluku region, possesses untapped therapeutic potential despite the presence of secondary metabolite chemicals believed to have larvicidal properties. This study aims to evaluate the biolarvicidal efficacy of the leaf extract of Pometia pinnata against Aedes aegypti's larvae, a DHF carrier. The extraction process used the maceration technique employing ethanol as the solvent. A larvicidal experiment was performed to evaluate the bioactivity against Aedes aegypti larvae. The findings indicated that the leaf extract of Pometia pinnata possesses larvicidal properties against Aedes aegypti larvae, as evidenced by an LC50 value of 0.101%. The results offer insights into the possible utilisation of Pometia pinnata leaf extract as a viable source of active compounds for developing biolarvicides to control dengue vectors.
A Systematic Review and Meta-Analysis of Non-Antibiotic Agents in Comparison to Antibiotic Therapies for Prevention of Recurrent Urinary Tract Infection Munawwir, Abdul; Syuaib, Achmad
Brawijaya Journal of Urology Vol. 5 No. 02 (2025): Brawijaya Journal of Urology
Publisher : Department of Urology, Faculty of Medicine, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/bjurology.2025.005.02.3

Abstract

Introduction. Prolonged antibiotic usage can lead to modifications in the normal gastrointestinal tract and vaginal microbiome, which contributes to the UTI recurrence. This study aims to assess the impact of non-antibiotic therapies compared to antibiotic interventions in the prevention of recurrent urinary tract infections (UTIs). Methods. A systematic literature search was carried out from the PubMed, Google Scholar, Cochrane, and ScienceDirect databases published from 2013–2023, adjusted for inclusion and exclusion criteria. Keywords and Medical Subject Headings (MeSH) used were urinary tract infection, UTI, recurrent UTI, antibiotics, anti-bacterial agents, antimicrobial versus non antibiotic agents, probiotics, cranberries, D-mannose, vitamins, NSAID, prevention, treatment. The RevMan 5.3 program was used to analyze the risk of recurrent UTIs. Forest plot analysis was used to present relative risk estimates from individual studies and combined meta-analysis results. Results. Six studies were deemed eligible for quantitative synthesis and were included in this meta-analysis. This meta-analysis study showed a large heterogeneity, with p= 0.006 and I²= 85%. Pooled analysis using a fixed effect model showed the development of recurrent UTI was significantly lower in women with symptomatic UTI who were given non-antibiotic interventions compared to antibiotic interventions, with a relative risk of 0.75 (95% confidence interval (CI)= 0.61–0.92). This shows that non-antibiotic interventions significantly reduce the incidence of recurrent UTI compared to antibiotic interventions. Conclusion. Non-antibiotics interventions such as cranberry extract, D-mannose, NSAIDs, and herbal medicines can prevent recurrent UTI, and the results appear to be better or the same as antibiotic interventions. Meta-analyses should consider small numbers of studies with varying study designs and quality as well as small overall sample sizes.
Skrining Tekanan Darah dan Gula Darah pada Masyarakat di Desa Buki, Kabupaten Selayar, Sulawesi Selatan Syuaib, Achmad; Ukratalo, Abdul M; Assagaf, Abdur Rahman
WASATHON Jurnal Pengabdian Masyarakat Vol 3 No 01 (2025)
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/wasathon.v3i01.1494

Abstract

Non-communicable diseases (NCDs) such as hypertension, diabetes mellitus, and coronary heart disease are among the leading causes of death in Indonesia. Health screening is an effective method in the prevention of NCDs, particularly for measuring blood pressure and blood glucose levels. The objective of this community service activity is to identify individuals at high risk of developing hypertension and diabetes mellitus, as well as to raise public awareness about the importance of adopting a healthy lifestyle as a preventive measure against these two diseases. This activity utilized a social health service approach, with the main focus being to provide free healthcare services to the community in Buki Village, Selayar Regency, South Sulawesi. A total of 50 participants attended this activity. The program was divided into three phases: preparation, implementation, and evaluation. The results of the community service show that, out of the 50 participants who underwent health screening, 6 individuals were found to have hypertension and 2 individuals had diabetes mellitus. This activity not only helped increase public awareness of the risks of NCDs but also served as an effective preventive step to avoid the progression of more serious health conditions in the future.
Co-Authors Assagaf, Abdur Rahman Embisa, Yushar A Kaliky, Arief Rahman S Loilatu, Muhammad Fitrah Manery, Dodikrisno E Muhammad, Alfaro Munawwir, Abdul Nanere, Bill E Pangemanan, Victory O Ukratalo, Abdul M