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Putriana, Susanti
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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The Evaluation of Clove oil Concentration on Physicochemical and Antimicrobial Activity in the Laponite Gel Delivery System Ermawati, Dian Eka; Putriana, Susanti; Setyowati, Tri; Kuntari, Tabita Putri; Salsabila, Fitri; Kartikasari, M. Nur Dewi
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15875

Abstract

Recurrent Aphthous Stomatitis (SAR) is inflammation in the oral mucosa. One of the factors that can cause SAR is bacterial and fungal infections of the oral mucosa. Clove oil is an essential oil that contains eugenol and has antimicrobial, analgesic, anti-inflammatory, and antioxidant activities. Clove oil in this study resulted from steam distillation with an eugenol content of 71.06%. Clove oil as an antimicrobial topical requires a drug delivery system that is easy and comfortable to apply. Laponite is a synthetic hydrophilic layered silicate that can hydrate and expand when water is added, is compatible with the properties of active ingredients, and is without an emulsifier. Please state the objective of this research. This research aims to determine the effect of variations in the concentration of clove oil incorporated in laponite on the gel's physicochemical properties and antimicrobial activity. Laponite with a concentration of 2.5% was developed in water and then added to clove oil with a concentration of 2%, 4% and 6%. Physicochemical properties test of oral gel preparations includes organoleptic tests, homogeneity, pH, adhesion, and spreadability tests. Antimicrobial activity test to Streptococcus mutans bacteria and Candida albicans fungi. The research showed that a gel preparation using laponite with a concentration of 2.5% was semi-solid with a clove oil odor. Clove oil, with an eugenol content of 71.06%, has potent antimicrobial activity. The higher concentration of clove oil increases the viscosity and sticky time but decreases the pH and spreadability. The adhesive time and pH of the gel are suitable for application to the oral mucosa with mouth ulcers, and 2.5% laponite can form a gel preparation that meets the gel's physicochemical properties and antimicrobial activity.
The Evaluation of Clove oil Concentration on Physicochemical and Antimicrobial Activity in the Laponite Gel Delivery System Ermawati, Dian Eka; Putriana, Susanti; Setyowati, Tri; Kuntari, Tabita Putri; Salsabila, Fitri; Kartikasari, M. Nur Dewi
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15875

Abstract

Recurrent Aphthous Stomatitis (SAR) is inflammation in the oral mucosa. One of the factors that can cause SAR is bacterial and fungal infections of the oral mucosa. Clove oil is an essential oil that contains eugenol and has antimicrobial, analgesic, anti-inflammatory, and antioxidant activities. Clove oil in this study resulted from steam distillation with an eugenol content of 71.06%. Clove oil as an antimicrobial topical requires a drug delivery system that is easy and comfortable to apply. Laponite is a synthetic hydrophilic layered silicate that can hydrate and expand when water is added, is compatible with the properties of active ingredients, and is without an emulsifier. Please state the objective of this research. This research aims to determine the effect of variations in the concentration of clove oil incorporated in laponite on the gel's physicochemical properties and antimicrobial activity. Laponite with a concentration of 2.5% was developed in water and then added to clove oil with a concentration of 2%, 4% and 6%. Physicochemical properties test of oral gel preparations includes organoleptic tests, homogeneity, pH, adhesion, and spreadability tests. Antimicrobial activity test to Streptococcus mutans bacteria and Candida albicans fungi. The research showed that a gel preparation using laponite with a concentration of 2.5% was semi-solid with a clove oil odor. Clove oil, with an eugenol content of 71.06%, has potent antimicrobial activity. The higher concentration of clove oil increases the viscosity and sticky time but decreases the pH and spreadability. The adhesive time and pH of the gel are suitable for application to the oral mucosa with mouth ulcers, and 2.5% laponite can form a gel preparation that meets the gel's physicochemical properties and antimicrobial activity.
The Effect of Citronella oil Concentration on Physicochemical Properties of Laponite Hydrogel and Antimicrobial Activity Test to Streptococcus aureus ATCC 25923 and Candida albicans ATCC 14053 Ermawati, Dian Eka; Putriana, Susanti; Susanto, Nindita Claurisa Amaris
Smart Medical Journal Vol 7, No 2 (2024): August
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v7i2.92213

Abstract

Introduction: The Citronella plant produces 78 -85% citral oil. This oil has antimicrobial activity. The oil was developed as an antimicrobial topical and incorporated into laponite hydrogel for optimal use. Laponite hydrogel has a cooling sensation and is compatible with polar and non-polar active substances. This study aims to evaluate the effect of citronella oil concentration on physicochemical properties and examine its antimicrobial activity.Methods: The Citronella plant was distilled using the steam distillation method and analyzed using the GC-MS. The laponite hydrogel was prepared with three concentrations: 6%, 8%, and 10%. Physicochemical properties included pH value, viscosity, stickiness, spreadability, and organoleptics, and the chosen formula was tested for antimicrobial activity. The research data were compared with relevant literature, and ANOVA statistics were analyzed with a confidence level of 95%.Results: Based on the research results, increasing the concentration of citronella oil caused the laponite hydrogel to become increasingly cloudy, viscosity, and sickness but decreased the pH and spreadability. Citronella oil concentration of 8% is the chosen formula that fulfills the best hydrogel preparation with evaluation results of pH value of 7.24 ± 0.064, spreadability of 5.68 ± 0.320 cm, thickness of 1.25 ± 0.012 seconds, and viscosity of 23596.3 ± 227.55 mPa. s. The citronella oil hydrogel has antibacterial and antifungal properties and moderate strong inhibitory.Conclution: As a delivery system for citronella oil, Laponite can be developed as a pharmaceutical preparation to treat mouth ulcers as an alternative synthetic product with good antimicrobial potential.
Co-Authors ERMAWATI, DIAN EKA Kuntari, Tabita Putri M. Nur Dewi Kartikasari Salsabila, Fitri Setyowati, Tri Susanto, Nindita Claurisa Amaris