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All Journal Berkala Ilmiah Kedokteran Duta Wacana Patria : Jurnal Pengabdian Kepada Masyarakat Jurnal Kedokteran Meditek
Widowati, Galuh
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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ROLE OF HYPOXIA INDUCIBLE FACTOR-1? IN LYMPH NODE METASTASIS OF BREAST CANCER Widowati, Galuh
Berkala Ilmiah Kedokteran Duta Wacana Vol. 9 No. 2 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v9i2.1014

Abstract

Background: Lymph node metastasis in breast cancer is a clinical parameter used to predict a patient’s prognosis. Lymph node metastasis is affected by numerous factors, one of which is hypoxic conditions that trigger the expression of HIF-1?, a transcription factor expressed by cells in hypoxia. To date, the role of HIF-1? in lymph node metastasis in breast cancer requires further research. Objective: This review aimed to describe the possible role of HIF-1? in breast cancer lymph node metastasis. Methods: PubMed and Google Scholar databases were searched for articles using Boolean operations with keywords related to HIF-1? expression and lymph node metastasis of breast cancer. We have limited the 10 years of publication to be included in this review. Results: HIF-1? has the potential to induce epithelial-mesenchymal transition, extracellular matrix invasion, matrix degradation, and lymphangiogenesis through various target gene expression and signaling pathways, leading to lymph node metastasis of breast cancer cells.
Edukasi Bahaya Merokok dan Kanker Payudara serta Lokakarya Berhenti Merokok dan SADARI di SMA Immanuel Kalasan Yogyakarta Saputra, Lili Ananta; Widowati, Galuh; Jayadi, Tejo; Haryaningtyas, Estherina Fajar; Jawa, Tresia
Patria : Jurnal Pengabdian Kepada Masyarakat SPECIAL ISSUE - SENDIMAS IX
Publisher : Universitas Katolik Soegijapranata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24167/patria.v1i1.12727

Abstract

Kanker menjadi penyebab kematian kedua terbanyak di dunia. Provinsi Daerah Istimewa Yogyakarta (DIY) berada pada peringkat pertama prevalensi kanker terbanyak. Edukasi mengenai kanker diharapkan dapat membantu meningkatkan kesadaran masyarakat untuk menjauhi faktor risiko kanker dan melakukan deteksi dini sehingga angka kejadian kanker dapat berkurang.  Departemen Patologi Anatomik Fakultas Kedokteran Universitas Kristen Duta Wacana (PA FK UKDW) mengadakan program pengabdian masyarakat berupa edukasi dengan topik bahaya merokok dan kanker payudara, dilanjutkan dengan lokakarya berhenti merokok dan pemeriksaan payudara sendiri (SADARI) di SMA Immanuel Kalasan, Yogyakarta. Target peserta yang hadir adalah seluruh guru dan siswa sebanyak 46 orang. Metode yang digunakan dalam kegiatan ini adalah ceramah interaktif. Materi edukasi yang disampaikan adalah mengenai definisi, gejala, pencegahan, dan deteksi dini kanker payudara serta bahaya merokok. Lokakarya dibagi menjadi 2 kelompok. Peserta laki-laki mengikuti lokakarya berupa diskusi dan komitmen untuk berhenti merokok. Peserta perempuan mengikuti lokakarya SADARI, dibagi menjadi kelompok kecil dan masing-masing memeragakan Teknik SADARI. Peserta antusias mengikuti kegiatan ini dengan mengajukan pertanyaan dan berpartisipasi aktif dalam lokakarya. Diharapkan dengan adanya kegiatan ini, pengetahuan mengenai kanker pada usia sekolah semakin meningkat dan juga meningkatkan kesadaran untuk SADARI dan berhenti merokok. Program edukasi kesehatan dan lokakarya ini diharapkan dapat terus berlanjut dengan target sasaran yang lebih luas.
Analysis of Intra-Articular Injection of Triamcinolone Acetonide on Changes in The Quality of Life of Patients With Knee Osteoarthritis Lestari, Dewi; Widowati, Galuh
Jurnal Kedokteran Meditek Vol 31 No 4 (2025): JULI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i4.3503

Abstract

Introduction: Knee osteoarthritis is the most common articular disease in developed countries that caused chronic disability and reduction of the quality of life in the elderly. Intra-articular (IA) injections are selected if other conservative therapies are ineffective. Purpose: This study aimed to measure the effect of IA injection of triamcinolone acetonide on the quality of life in knee osteoarthritis’s patients. Methods: This observational research was conducted in three steps: filling out questionnaires by patients, interviewing patients, and retrieving patients' data from medical records. The patients' quality of life scores measure before and 4 weeks after therapy, using the AIMS2-SF score, VAS EQ-5D-5L, and Indonesian EQ-5D-5L. The result will be declared statistically significant if p<0.05. Results: No statistically significant difference found in AIMS2-SF scores (p> 0.05) for Symptoms, Social, Occupational domains, and in VAS EQ-5D-5L (p> 0.05). A significant difference was found in AIMS2-SF scores for Physical, Emotional domains and in the EQ-5D-5l Score. Multivariate analysis showed that patients' characteristics and knee osteoarthritis disease did not affect the AIMS2-SF, EQ-5D-5L, and VAS score. Conclusion: IA injection of triamcinolone acetonide has a potential effect to increase the number of domains in the patient's quality of life after 4 weeks of therapy.
Co-Authors Dewi Lestari Haryaningtyas, Estherina Fajar Jawa, Tresia SAPUTRA, LILI ANANTA Tejo Jayadi, Tejo