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All Journal International Journal Of Science, Technology & Management (IJSTM) Jurnal Kebidanan, Keperawatan dan Kesehatan (J-BIKES) International Journal Of Health And Social Behavior
Dasawanti, Yoan
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Transportation

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Formulasi Dan Uji Sediaan Lotion Pelembab Berbasis Ekstrak Etanol Kulit Buah Naga Super Merah (Hylocereus Costaricensis) (F.A.C. Weber) Britton & Rose Dasawanti, Yoan; Samaniyah, Siti
JURNAL KEBIDANAN, KEPERAWATAN DAN KESEHATAN (BIKES) Vol 4, No 1 (2024): J-BIKES JULI
Publisher : Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-bikes.v4i1.82

Abstract

Kulit buah naga super merah (Hylocereus costaricensis (F.A.C. Weber) Britton Rose) mengandung alkaloid, flavonoid, fenolik, karoten, dan fitoalbumin, yang memiliki kapasitas antioksidan tinggi serta efek antiproliferatif. Penelitian ini bertujuan memformulasikan sedian lotion pelembab berbasis ekstrak kulit buah naga super merah. Sampel diambil secara purposive dan diekstraksi menggunakan metode maserasi dengan menggunakan pelarut etanol 70% kemudian dipekatkan menggunakan rotary evaporator. Konsentrasi ekstrak buah naga super merah yang digunakan yaitu 3%, 5%, dan 7%. Stabilitas sediaan lotion dilakukan selama enam siklus (cycling test). Evaluasi sediaan lotion meliputi uji organoleptik, uji homogenitas, uji pH, uji viskositas, uji iritasi kulit, dan uji kelembaban kulit. Hasil menunjukkan bahwa sediaan lotion stabil selama penyimpanan, dengan konsistensi sediaan  lotion berbentuk semi-padat, homogen, pH sediaan lotion 6,03-6,69, viskositas sediaan lotion 900-3459 cP, dan tidak menimbulkan iritasi pada kulit. Berdasarkan uji keseluruhan, ekstrak kulit buah naga super merah dapat diformulasikan menjadi sediaan lotion pelembab yang efektif dan aman digunakan.
Effectiveness Test Of Anti-Acne Emulsigel Preparation Based On Clove Leaf Oil (Syzygium Aromaticum (L.) Merr & Perry) Yoan Dasawanti; Candrika Candrika; Khaira Banu
International Journal of Health and Social Behavior Vol. 2 No. 1 (2025): February: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v2i1.286

Abstract

Acne is a common skin problem caused by the accumulation of oil that blocks the hair follicles. Factors contributing to acne include bacterial colonization by Staphylococcus epidermidis and Propionibacterium acnes, increased sebum production, and follicle disturbances. Generally, acne treatment aims to reduce sebum production, address inflammation, decrease bacterial colonization, and improve skin conditions. The commonly used therapies include antibiotics and retinoids, although challenges such as antibiotic resistance and side effects exist. As an alternative, clove (Syzygium aromaticum) contains eugenol, which has antibacterial properties that are effective against the growth of Propionibacterium acnes. A combination of emulsion and gel (emulsisponge) can be a stable and effective formulation for acne treatment. This study aimed to formulate clove leaf oil into an emulsified gel preparation, evaluate the formulation, and test its antibacterial activity. The study began with distillation of clove leaf oil and its formulation into an emulsion gel. Evaluation of the emulsion included organoleptic, homogeneity, pH, viscosity, particle size, skin irritation, and antibacterial activity tests. The results showed that The emulsified gel was white, aromatic, thick, and homogeneous. The emulsion has pH (4.5-6.5), viscosity (6500-9500 mPa.s), and particle size (8.3-14.1 µm), and remains stable for 12 weeks at room temperature, low temperature, and high temperature, without causing skin irritation. Antibacterial test results indicated that the emulsion exhibited a highly active inhibition zone.
Formulation And Evaluation Of Nanoemulgel Clove Leaf Oil (Sygyzium Aromaticum) (L.) Merr & Perry As Anti-Acne Dasawanti, Yoan; Reveny, Julia; Sumaiyah, Sumaiyah
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.681

Abstract

Acne also known as acne vulgaris, is an inflammatory condition of the polysebaceous layer that is brought on by the buildup of keratin. Active oil glands under the skin cause acne. Androgen hormones function as a stimulant for this activity. Cloves are herbal plants that contain essential oil chemicals. The chemical composition of clove leaf oil is mainly composed of eugenol. Eugenol has pharmacological effects as antibacterial, analgesic and anti-inflammatory. Nanoemulsion is a nanocarrier that gets a lot of attention, because of its small particle size so that it can be thermodynamically stable and can increase drug penetration. Recent advances in nanoemulsion research have created new prospects in a number of industries, including pharmaceuticals, biotechnology, food, and cosmetics. This research was conducted by formulating clove leaf oil into nanoemulgel preparations, followed by evaluation of the preparations and testing of antibacterial activity against acne-causing bacteria. The result of the nanoemulgel formulation is yellow, smells of clove leaf oil, is transparent and homogeneous. Nanoemulgel viscosity 3434-3109 M.Pas, pH 6.15-6.41 and particle size 12.3-13.3 nm. Physical studies of nanoemulgel been carried out for three cycles and there is no change in color, change in odor and phase separation. The results of the antibacterial activity of Staphylococcus epidermidis at NEG1 12.03 mm, NEG2 16.93 mm, NEG3 18.96 mm and EG 18.03 mm. The results of the antibacterial activity of Propionibacterium acnes at NEG1 11.50 mm, NEG2 16.16 mm, NEG3 18.03 mm and EG 17.33 mm. The results of the study concluded that clove leaf oil nanoemulgel with a concentration of 7% was the best formula, because it is stable during storage and has the greatest antibacterial activity compared to emulgel.
Co-Authors Julia Reveny Khaira Banu Siswahyudianto Siti Samaniyah Sumaiyah, Sumaiyah