Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Journal of Fundamental and Applied Pharmaceutical Science Journal Of Pharmacy
Putri, Nurdina
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Isolation and Determination of Antioxidant Activity from Methanol Extract of Uncaria cordata (Lour.) Merr. Leaves Rahmawati, Noveri; Endamora; Rizky Rindiana; Husnunnisa; Irfan, Nawwar; Amini, Rahmi; Putri, Nurdina; Putri Tri Hartini; Khazanah Nurain Nurdin; Restu Anisa Putri; Sari Rahmadhani
The Journal Of Pharmacy Vol. 3 No. 2 (2026): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Uncaria cordata (Lour. Merr. is one plants genus Uncaria growing in Indonesia, there has been no publication content of secondary metabolites are active as antioxidants. Antioxidant activity by DPPH test (1,1-diphenyl-2 pikrilhidrazil) generate IC50 n-hexane extract did not have IC50 values ​​and can only inhibit 34.234% at a concentration of 1000 µg/mL, ethyl acetate extract of 704.478 µg/mL, methanol extract of 6.778 µg/mL. Methanol extract with the highest IC50 isolation by column chromatography and obtained compound isolates F2. In the test with the Lieberman Burchard color reagent terpenoids positive (red) compounds derived from class terpenoids possibility. The results UV spectrum gives maximum absorption at a wavelength of 293.50 nm and 310.5 nm. Infrared spectrum showed absorption 3410 cm-1 (OH), 2933 cm-1 (CH), 1690 cm-1 (C = O), 1457 cm-1 (CH), and 1036 cm-1 (CC). The antioxidant activity (IC50) F2 compounds have not active category.
Potential of Polar Subfraction Alkaloids from Ethyl Acetate Fraction of Uncaria nervosa Elmer Leaves on the Migration Effect of MCF-7/HER2 Breast Cancer Cells Rahmawati, Noveri; Putri, Nurdina
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.31373

Abstract

Breast cancer, particularly the HER2-positive subtype, remains a major global health burden. Medicinal plants are increasingly being explored as sources of anticancer agents due to their chemical diversity and multitarget mechanisms of action. Uncaria nervosa Elmer, an Indonesian ethnomedicinal plant, has shown promising anticancer potential; however, evidence at the subfraction level is limited. This study aimed to evaluate the cytotoxic activity and the inhibitory effect on cell migration of the polar subfraction (SF-I) derived from the ethyl acetate fraction of Uncaria nervosa leaves against MCF-7/HER2 breast cancer cells. Cytotoxicity was assessed using the MTT assay, and cell migration was analyzed using the scratch-wound healing assay. The polar subfraction (SF-I) exhibited dose-dependent cytotoxicity and significantly inhibited cell migration at sub-cytotoxic concentrations. These findings indicate that polar constituents of Uncaria nervosa exhibit dual anticancer activity by suppressing cancer cell viability and motility, supporting their potential development as phytopharmaceutical candidates for HER2-positive breast cancer.
Co-Authors Amini, Rahmi Endamora Husnunnisa Irfan, Nawwar Khazanah Nurain Nurdin Noveri Rahmawati Putri Tri Hartini Restu Anisa Putri Rizky Rindiana Sari Rahmadhani