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All Journal Jurnal Riset Biologi dan Aplikasinya Jurnal Tadris IPA Indonesia
Nur Faizah, Ulinnuha
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Immunology & microbiology Medicine & Pharmacology Physics Social Sciences

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Morpho-histological Study of the Rat Spleen Post-Induction of Sodium Nitrite and Acorus calamus L. Rhizome Ethanolic Extract Amira, Siti; Febriani, Husnarika; Syukriah, Syukriah; Nur Faizah, Ulinnuha
Jurnal Riset Biologi dan Aplikasinya Vol. 5 No. 2 (2023)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jrba.v5n2.p89-97

Abstract

Sodium nitrite (NaNO2) is one of the most inorganic salts and is often used in processed meat products. Long-term consumption of sodium nitrite has been reported to cause of oxidative stress and spleen histological changes. Therefore, anti-oxidative effects are needed from natural ingredients such as Acorus calamus L. The study aims to determine the effect of A.calamus L. rhizome extract on anatomical structure and histological changes in the rat spleen induced with NaNO2. We used a completely randomized design with twenty-five male rats divided into 5 groups. Negative control (NC) was given 0.5% CMC for 40 days; positive control (PC) on days 1-15 was given NaNO2 (50 mg/kg BW); on days 16-30 given (50 mg/kg BW) NaNO2 + 0.5% CMC and on days 31-40 given 0,5% carboxy methyl cellulose (CMC). Treatment 1 (T1), Treatment 2 (T2), and Treatment 3 (T3) on days 1-15 were given NaNO2 doses of 50 mg; and; on days 16-30, groups T1, T2, and T3 were given NaNO2 + extract with each predetermined dose (250 mg/kg BW for T1, 500 mg/kg BW for T2, and 750 mg/kg BW for T3). For days 31-40 groups T1, T2, and T3 were given extracts with each predetermined dose. Results revealed that the extract of the A. calamus L. rhizome affects weight, length, and width of the spleen (P<0.05); and bleeding lesions; while having no noticeable effect (P<0.05) and having a noticeable effect on the area of the white pulp (P<0.05). Administration of ethanol extract of A. calamus L. at a dose of 250 mg/kg BW has an impact on improving spleen length; a dose of 500 mg/kg BW has an impact on the weight and length of the spleen; and a dose of 750 mg / kg BW has an impact on improving spleen length, but the size variation is still in the normal category. While extracts at doses of 250 and 500 mg/kg BW have a repair impact on tissue shrinkage in damaged white pulp. 
Efektivitas Model Pembelajaran Problem Based Learning (PBL) Berbasis Pendekatan Socioscientific Issues (SSI) untuk Meningkatkan Kemampuan Berpikir Kreatif di MTs Al-Islam Joresan Ayu Rahmadhani, Agna; Nur Faizah, Ulinnuha
Jurnal Tadris IPA Indonesia Vol. 5 No. 1 (2025)
Publisher : Tadris IPA IAIN Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/jtii.v5i1.3812

Abstract

Education plays an important role in developing students' knowledge through learning and teaching processes such as developing students' skills, abilities and learning interests. Science learning in the 21st century also prioritizes students' skills to be actively involved in the classroom to build their knowledge. In fact, many students are still passive and unable to develop creative thinking skills. There is a need to implement learning strategies to improve students' creative thinking abilities. This research aims to determine the implementation of the learning model both in terms of the implementation of the learning model, determine student activities based on creative thinking abilities, determine the effectiveness of the problem based learning (PBL) learning model based on socioscientific issues (SSI) to improve students' creative thinking abilities at MTs Al-Islam Joresan . Quantitative research type, quasi-experimental method and nonequivalent control group design. Data collection was done through observation sheets and pretest-posttest questions. Data obtained was analyzed through descriptive statistical tests and inferential statistics such as independent tests, linearity tests, Ancova tests, Cohen's d Effect Size tests and N-Gain tests. Based on the results of data analysis, it shows that (1) the implementation of the problem based learning model based on socioscientific issues in terms of teacher implementation and student activities can be carried out very well. (2) Student activities based on creative thinking abilities also include creative criteria for all indicators. (3) The problem based learning model is effective in improving students' creative thinking abilities.
Co-Authors Amira, Siti Ayu Rahmadhani, Agna Husnarika Febriani, Husnarika Syukriah Syukriah, Syukriah