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All Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Cermin Dunia Kedokteran
Luvianto, Juven
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Health Professions Medicine & Pharmacology Public Health

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Euphorbia milii and propolis combination tea reduced hepatic steatosis and hepatocyte apoptosis in high-fat diet rat model Linawati, Ni Made; Sundari, Luh Putu Ratna; Widarta, I Wayan Rai; Arijana, I Gusti Kamasan Nyoman; Wande, I Nyoman; Luvianto, Juven
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art10

Abstract

Background: Dyslipidemia can cause various organ disorders, such as fatty liver disease. Over time, fatty liver disease has become more commonplace worldwide and may cause mortality if the progression worsens. Natural components from Euphorbia milii (E. milii) and propolis (EMP) have been demonstrated as immunomodulators that reduce total cholesterol levels.Objective: To prove the effect of EMP tea on inhibiting fatty liver and hepatocyte apoptosis in high-fat diet (HFD)-induced rats.Methods: This study applied a post-test-only control group design using 18 Wistar rats, which were divided into three groups: K0 (received standard feed), KN (received HFD of 2 g/200 g Body weight (BW) in a day), and P (received HFD of 2 g/200 g BW in a day and EMP of tea 40 mg/100 g BW in a day). The interventions were conducted for 30 days, followed by termination on day 31 for liver tissue collection and analysis. We calculated the hepatic steatosis with the help of hematoxylin-eosin (HE) staining. Hepatocyte apoptosis was also determined with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining.Results: The K0 group had a lower hepatic steatosis percentage (17.87 ± 1.81) than KN (63.75 ± 15.88). We also found no hepatocyte apoptosis in the K0 but a high hepatocyte apoptosis index in the KN (3.98 ± 0.29). The combination of EMP tea in HFD-induced rats significantly reduced hepatic steatosis and apoptosis percentage (25.33 ± 1.17 and 0.91 ± 0.61, respectively). Conclusion: We demonstrated that combining EMP tea reduced hepatic steatosis and hepatocyte apoptotic index in HFD-induced rats, suggesting its potential as a treatment for these conditions.                                       
Perdarahan Limpa Tertunda: Tinjauan Pustaka Luvianto, Juven; Periadijaya, I Wayan
Cermin Dunia Kedokteran Vol 53 No 02 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i02.1711

Abstract

Delayed spleen hemorrhage (DSH) is defined as rupture or hemorrhage of the spleen occurring 48 hours or more after blunt trauma. Although relatively uncommon, DSH is associated with a higher mortality rate compared to acute splenic injury. The interval between the initial traumaand the onset of DSH may range from several days to weeks or even months, and it may also occur following minor trauma. The spleen is a highly vascular organ, making splenic injury a potentially life-threatening condition due to the risk of intra-abdominal hemorrhage. DSH can develop in patients who were previously hemodynamically stable and had no radiological evidence of splenic injury on initial imaging. Diagnosis is often challenging because clinical manifestations may be nonspecific and long time interval since the trauma. Imaging studies, particularly computed tomography, play a crucial role in confirming the diagnosis and assessing the severity of splenic injury. Management of DSH depends on the patient’s hemodynamic status and the grade of the splenic injury, and may include non-operative management, embolization, or surgical intervention. Early recognition is essential to improving clinical awareness, accelerating diagnosis, and reducing morbidity and mortality risks.
Co-Authors I Gusti Kamasan Nyoman Arijana I Nyoman Wande I Wayan Rai Widarta Luh Putu Ratna Sundari Ni Made Linawati Periadijaya, I Wayan