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All Journal HAYATI Journal of Biosciences Engagement: Jurnal Pengabdian Kepada Masyarakat
Joko Raharjo, Sentot
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Earth & Planetary Sciences Education Social Sciences

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Education and Mentoring on Organic Fertilizer Using PGPR Biodecomposer for Karang Taruna BABE in Bakalan, Bululawang, Malang Regency Joko Raharjo, Sentot; In Oktavia, Anggraeni; Oktavia Rahayu, Lina
Engagement: Jurnal Pengabdian Kepada Masyarakat Vol 8 No 2 (2024): November 2024
Publisher : Asosiasi Dosen Pengembang Masyarajat (ADPEMAS) Forum Komunikasi Dosen Peneliti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29062/engagement.v8i2.1671

Abstract

The existence of Minister of Agriculture Regulation Number 10 of 2022 concerning restrictions on national fertilizer subsidies among farmers requires alternative development of fertilizer processing. The aim of this Community Service is to educate and assist the BABE youth organization and residents of Bakalan village, Bululawang, Malang Regency in the Rapid Processing of Organic Fertilizer using the Plant Growth Promoting Rhizobacteria (PGPR) Biodecomposer. The method of this activity is Participatory Action Research (PAR) including a survey of the potential for rapid processing of organic fertilizer, outreach and education as well as assistance in processing it. The result of community service activities is increased knowledge and ability of the community in processing cow dung waste into organic fertilizer products with quality that complies with government regulations. The conclusion of this activity is that education and mentoring to youth organizations and residents of Bakalan village, Bululawang, Malang Regency can increase the knowledge and skills of village residents in the production of Rapid Processing of Organic Fertilizer Using PGPR.
Anti-Inflammatory Activity of Phyllanthus niruri L. Leaf Extract: In Vitro Study on RAW 264.7 Macrophage Cells and In Silico Analysis Intan Wiratmini, Ngurah; Pharmawati, Made; Sukmaningsih, Anak Agung Sagung Alit; Joko Raharjo, Sentot; Widowati, Wahyu
HAYATI Journal of Biosciences Vol. 32 No. 2 (2025): March 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.2.287-299

Abstract

Phyllanthus niruri L. is a medicinal plant recognized for its wide range of therapeutic benefits, particularly its anti-inflammatory properties. This research focused on assessing the impact of P. niruri leaf extract on pro-inflammatory cytokines in vitro using RAW 264.7 macrophage cells, analyze its phytochemical composition, and validate its potential anti-inflammatory mechanisms through molecular docking studies. The extract was analyzed for its phytochemical composition using LC-MS, revealing the presence of sesquiterpene glycosides, flavonoid glycosides, and tannins among the identified compounds. Cell viability tests showed that the extract was not toxic to the cells at concentrations up to 50 µg/ml. Treatment with the extract significantly reduced the levels of pro-inflammatory cytokines TNF-α and IL-1β in LPS-induced RAW 264.7 cells, with the most effective concentration being 50 µg/ml. Molecular docking studies further supported the anti-inflammatory potential of the extract by demonstrating its ability to inhibit COX-2 and TNF-alpha. These findings suggest that P. niruri leaf extract has promising anti-inflammatory properties and needs further investigation as a potential treatment for inflammatory diseases. The in silico study provided insights into the molecular interactions between the extract's compounds and inflammatory targets, supporting its anti-inflammatory mechanism of action.
Co-Authors In Oktavia, Anggraeni MADE PHARMAWATI Ngurah Intan Wiratmini Oktavia Rahayu, Lina WAHYU WIDOWATI