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All Journal Journal of Pharmaceutical Care and Sciences Promotor: Jurnal Mahasiswa Kesehatan Masyarakat
Deviani, Norma
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Literature Review: Guava Leaves (Psidium Guajava) for Treating Diarrhea Rohama, Rohama; Febriani, Agnesia; Khairunnisa, Aisya F.; Mawarid, M.T.F.; Deviani, Norma
PROMOTOR Vol. 7 No. 5 (2024): OKTOBER
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v7i5.835

Abstract

Diarrhea is a significant health problem, especially in developing countries. Guava leaves (Psidium guajava) have long been used in traditional medicine to treat diarrhea. This study aims to review the literature on the effectiveness of guava leaves in treating diarrhea by focusing on ten aspects: raw material name, raw material content, raw material composition, active substance content, efficacy claims, empirical data, raw material standardization, preclinical test, toxicity test, and clinical trial. The results of several studies show that guava leaves contain tannins, flavonoids, saponins, and essential oils that play a role in the antidiarrheal effect. Preclinical research shows a reduction in the frequency of bowel movements and an increase in stool consistency in animal models. Although empirical claims and preclinical trials support the use of guava leaves as a treatment for diarrhea, more research is still needed regarding the standardization of raw materials, toxicity tests, and clinical trials to ensure its overall efficacy and safety.
P Penetapan Kadar Flavonoid Total dan Nilai Sun Protection Factor (SPF) Fraksi Ekstrak Etanol Daun Sirih Muda (Piper betle L.) Deviani, Norma; Hakim, Ali Rakhman; Ikeh, Tri Sulapmi D.; Nastiti, Kunti
Jurnal Pelayanan Kefarmasian dan Sains Vol 5 No 1 (2024): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v5i1.617

Abstract

Background: Betel leaf (Piper betle L.) is a plant that contains many important secondary metabolite compounds, one of which is the flavonoid group. empirically in the community, especially in South Kalimantan, who use these leaves as a mixture of cold powder using young betel leaves as protection against sunlight.Objective: To determine the total flavonoid content of the young betel leaf extract fraction (Piper betle L.) and the sun protection factor (SPF) value in the distilled water and ethyl acetate fractions.Methods: The experimental method with a posttest-only control group design involved qualitative analysis using thin layer chromatography (TLC) and quantitative data using UV-Vis spectrophotometry to determine total flavonoid levels and sun protection factor (SPF) values using the Mansur method.Results: The TLC analysis confirmed the presence of flavonoid compounds. Quantitative analysis using UV-Vis spectrophotometry showed total flavonoid content of 14.4 mg EQ/g (1.44%) in distilled water and 16.4 mg EQ/g (1.64%) in the ethyl acetate fraction. The highest SPF value was 17.29 at 600 ppm in the ethyl acetate fraction (ultra protection), while the lowest was in the distilled water fraction at 200 ppm (minimum category).Conclusion: The young betel leaf extract fractions showed that the distilled water fraction contained 14.4 mg EQ/g (1.44%) flavonoids, while the ethyl acetate fraction had 16.4 mg EQ/g (1.64%). The highest SPF value of 17.29 (ultra protection) was found in the ethyl acetate fraction at 600 ppm.
Co-Authors Ali Rakhman Hakim Febriani, Agnesia Ikeh, Tri Sulapmi D. Khairunnisa, Aisya F. Mawarid, M.T.F. Nastiti, Kunti Rohama, Rohama