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All Journal Heart Science Journal Indonesian Journal of Cancer
Zenjaya, Kellyn Trycia
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Systemic Immune-Inflammation Index (SII) and NeutrophilLymphocyte Ratio (NLR) as a Promising Predictor for Advanced Stage Events during the Follow-Up Period in Hepato-Gastrointestinal Cancer Patients Zenjaya, Kellyn Trycia; Biutifasari, Verna; Yudadi, Redemptus; Wibowo, Prajogo
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1186

Abstract

Background: Tumor microenvironment has shown the role of inflammation in its progressivity. The heterogeneity of prognosis at the same TNM stage makes it difficult to classify patients who are more at risk of developing advanced stages. This study aimed to provide a deeper insight into the potential of cheap inflammation markers based on the Systemic ImmuneInflammation Index (SII) and Neutrophil-Lymphocyte Ratio (NLR) to predict the advanced stage during the follow-up period in patients with hepato-gastrointestinal cancer.Methods: Case-control research was conducted using 120 data of patients with hepatogastrointestinal cancer (Colorectal cancer (CRC), hepatocellular carcinoma (HCC), gastrointestinal stromal tumor (GIST), esophageal adenocarcinoma (EAC), pancreatic ductal adenocarcinoma (PDAC), cholangio carcinoma (CCA)) taken from patient medical records. The patients were divided into case and control groups based on the presence of advanced stage events during the follow-up period that were further classified by the NLR and SII value. The advanced-stage events were analyzed and compared between the two groups using Chi-Square and logistic regression analysis to perceive the predictive value of each ratio. Results: Patients with advanced-stage hepato-gastrointestinal cancer had higher NLR and SII than patients without advanced stage (p 0.001). The group of patients with advanced stages had an average NLR of 18.45 and an SII of 6588.13. The group of patients without advanced stages had an average NLR of 5.12 and SII of 1545.01. The cut-off value was determined using the ROC curve, for NLR was 6.48 (92.5% sensitivity and 71.2% specificity), and for SII was 2264.24 (92.5% sensitivity and 76.2% specificity).Conclusions: NLR and SII are cheap markers and have considerable potential for predicting advanced stage during the follow-up period in patients with hepato-gastrointestinal cancer. SII is more accurate as a predictor than NLR. These tools can be very useful in identifying the high-risk patients among the same TNM stage.
A potential coronary angiographic burden estimation (CABE) index based on age, fasting blood glucose, and atherogenic index of plasma Zenjaya, Kellyn Trycia; Priscilla, Kezia Rachel; Velisia, Maria Angela; Sukmawati, Sang Ayu Putu Wulan; Aditama, Dedi; Jovie, Benny; Diarsvitri, Wienta
Heart Science Journal Vol. 7 No. 4 (2026): Navigating High-Risk Cardiovascular Subsets: Premature Disease, Plaque Complexi
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.04.11

Abstract

Background: Coronary artery disease remains a major contributor to morbidity and mortality worldwide. Simple and accessible tools for estimating coronary angiographic disease burden may facilitate risk stratification, particularly in settings with limited resources.Objective: To develop and temporally internally validate a practical index for estimating coronary angiographic disease burden using routinely available clinical and metabolic parameters.Methods:  We retrospectively analyzed medical records of 414 patients for model derivation and 166 patients for temporal internal validation, who underwent coronary angiography at Dr. Ramelan Naval Central Hospital between 2024 and 2025. Angiographic burden was classified as mild (Gensini score <11) or moderate-to-severe (≥11). Candidate predictors were  evaluated using logistic regression, and model performance was assessed  using receiver operating characteristic (ROC) analysis.Result: Older age, higher fasting blood glucose (FBG), and atherogenic index of plasma (AIP) were independently associated with greater CAD burden (all p < 0.05), and were incorporated into the Coronary Angiographic Burden Estimation (CABE) Index. The model demonstrated fair discrimination in the derivation cohort (AUC 0.726;60.5% sensitivity and 73.2% specificity at the predefined cutoff) and showed consistent performance in the temporal validation cohort (AUC 0.729). Conclusion: The CABE index is a simple, association-based tool that estimates the likelihood of higher coronary angiographic burden using routinely available clinical and metabolic parameters. . The index demonstrated fair discrimination and consistent temporal validation performance. Further external multicenter validation is required before its broader application in clinical decision-making.
Co-Authors Aditama, Dedi JOVIE, BENNY Priscilla, Kezia Rachel Redemptus Yudadi Sukmawati, Sang Ayu Putu Wulan Velisia, Maria Angela Verna Biutifasari Wibowo, Prajogo Wienta Diarsvitri