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All Journal Promotif: Jurnal Kesehatan Masyarakat Indonesian Journal of Cancer
Zenjaya, Kellyn Trycia
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Systemic Immune-Inflammation Index (SII) and NeutrophilLymphocyte Ratio (NLR) as a Promising Predictor for Advanced Stage Events during the Follow-Up Period in Hepato-Gastrointestinal Cancer Patients Zenjaya, Kellyn Trycia; Biutifasari, Verna; Yudadi, Redemptus; Wibowo, Prajogo
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1186

Abstract

Background: Tumor microenvironment has shown the role of inflammation in its progressivity. The heterogeneity of prognosis at the same TNM stage makes it difficult to classify patients who are more at risk of developing advanced stages. This study aimed to provide a deeper insight into the potential of cheap inflammation markers based on the Systemic ImmuneInflammation Index (SII) and Neutrophil-Lymphocyte Ratio (NLR) to predict the advanced stage during the follow-up period in patients with hepato-gastrointestinal cancer.Methods: Case-control research was conducted using 120 data of patients with hepatogastrointestinal cancer (Colorectal cancer (CRC), hepatocellular carcinoma (HCC), gastrointestinal stromal tumor (GIST), esophageal adenocarcinoma (EAC), pancreatic ductal adenocarcinoma (PDAC), cholangio carcinoma (CCA)) taken from patient medical records. The patients were divided into case and control groups based on the presence of advanced stage events during the follow-up period that were further classified by the NLR and SII value. The advanced-stage events were analyzed and compared between the two groups using Chi-Square and logistic regression analysis to perceive the predictive value of each ratio. Results: Patients with advanced-stage hepato-gastrointestinal cancer had higher NLR and SII than patients without advanced stage (p 0.001). The group of patients with advanced stages had an average NLR of 18.45 and an SII of 6588.13. The group of patients without advanced stages had an average NLR of 5.12 and SII of 1545.01. The cut-off value was determined using the ROC curve, for NLR was 6.48 (92.5% sensitivity and 71.2% specificity), and for SII was 2264.24 (92.5% sensitivity and 76.2% specificity).Conclusions: NLR and SII are cheap markers and have considerable potential for predicting advanced stage during the follow-up period in patients with hepato-gastrointestinal cancer. SII is more accurate as a predictor than NLR. These tools can be very useful in identifying the high-risk patients among the same TNM stage.
Enhancing Knowledge and Awareness of Routine Hypertension Control and Medication in Panjang Jiwo, Surabaya Zenjaya, Kellyn Trycia; Adiwinoto, Ronald Pratama; Vivien Earlyanti, Callista; Abdul Azis, Bima; Fathir Fadhilah, Yahdiyan; Dinda Umardy, Fairuziah; Dewindra Candra Puspita, Amalia; Kurnia Cahya, Sekar; Nelya Rindayu, Dinnara; Roanna Gabrielle, Vania
Promotif : Jurnal Kesehatan Masyarakat Vol. 15 No. 1: JUNE 2025
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/promotif.v15i1.7381

Abstract

Background: The Tenggilis Public Health Center (Puskesmas Tenggilis) is devoted to implementing Community Health Efforts (UKM) to ensure the provision of high-quality healthcare services, focusing on the measurement, monitoring, and supervision of local health problems. A Self-Assessment Survey (Survey Mawas Diri” (SMD) in Indonesian language) was conducted in Panjang Jiwo Village, Surabaya, revealing hyperten”sion as a primary health issue. Characterized by a systolic blood pressure ?140 mmHg and a diastolic pressure ?90 mmHg, hypertension remains widespread, with many residents unaware of the necessity for lifelong medication adherence and routine blood pressure monitoring. Methods: To address this health challenge, a thorough analysis was conducted, examining the root causes through the "man, method, machine, and material" framework. This approach informed the development of a targeted intervention strategy. Results:The intervention involved designing and distributing a Hypertension Calendar, providing an accessible means for residents to record their blood pressure readings and track medication adherence throughout the year. The calendar serves as a useful tool during healthcare visits, fostering enhanced dialogue between patients and healthcare providers regarding hypertension management. Conclusions: The introduction of the Hypertension Calendar aims to empower individuals with essential knowledge and tools for effective hypertension management, ultimately contributing to improved health outcomes in the Panjang Jiwo community. Key words: Hypertension; Community Empowerment; Public Health; Health Promotion; Health Education
Co-Authors Abdul Azis, Bima Biutifasari, Verna Dewindra Candra Puspita, Amalia Dinda Umardy, Fairuziah Fathir Fadhilah, Yahdiyan Kurnia Cahya, Sekar Nelya Rindayu, Dinnara Roanna Gabrielle, Vania Ronald Pratama Adiwinoto Vivien Earlyanti, Callista Wibowo, Prajogo Yudadi, Redemptus