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Formulasi Dan Evaluasi Sediaan Tablet Ibuprofen Menggunakan Berbagai Bahan Pengikat Dalam Metode Granulasi Basah Nor Aida; Nafach Olya Warasky; Laila manada; Annur tasya alfiati; Sofi agustia putri
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1787

Abstract

The aim of this research is to conduct a study on the Formulation and Evaluation of Ibuprofen Tablet Preparations Using Various Binder Materials in the Wet Granulation Method. The method used in this research is a systematic literature review. The results of this study indicate that research on ibuprofen tablet formulations shows that the physical quality of tablets is greatly influenced by the selection of binders, disintegrants, lubricants, and other excipients. The appropriate binder ensures that the tablet has the correct hardness and can disintegrate properly, allowing the active ingredient to be effectively absorbed by the body. The right disintegrant is also crucial for speeding up the tablet's disintegration time, while the lubricant functions to reduce friction during tablet manufacturing, although it must be used in a balanced amount to avoid hindering dissolution. Furthermore, factors such as the moisture content of the granules and the physical properties of the granules also play a role in determining the tablet's quality. Studies show that the right formulation, such as a combination of CMC-Na, sorbitol, and amylum solani binders, can improve dissolution and bioavailability, leading to better therapeutic effectiveness. Overall, the selection of the appropriate materials and proportions in the formulation of ibuprofen tablets is crucial to produce tablets with high bioavailability and optimal therapeutic effects..
REVIEW JURNAL PENGELOLAAN LIMBAH CAIR DI INDUSTRI FARMASI Raudatul Jannah; Laila Manada; Nor Latifah
Jurnal Cakrawala Ilmiah Vol. 4 No. 10: Juni 2025
Publisher : Bajang Institute

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Abstract

Limbah cair yang dihasilkan oleh industri farmasi mengandung senyawa aktif farmasi (PhACs) serta parameter pencemar seperti Chemical Oxygen Demand (COD) dan Biological Oxygen Demand (BOD), yang bersifat persisten dan sulit terdegradasi secara alami, sehingga berpotensi mencemari lingkungan perairan. Penelitian ini bertujuan untuk mengkaji berbagai strategi dan teknologi pengolahan limbah cair di industri farmasi serta mengevaluasi efektivitasnya dalam menurunkan beban pencemar. Kajian ini menggunakan pendekatan studi pustaka terhadap literatur ilmiah dan dokumen resmi yang relevan. Hasil kajian menunjukkan bahwa teknologi pengolahan seperti kombinasi proses anaerobik-aerobik, sistem biofilter, koagulasi-flokulasi, serta metode reagen Fenton dan Advanced Oxidation Processes (AOPs) memiliki potensi tinggi dalam menurunkan kadar polutan. Wetland buatan juga terbukti efektif dan ramah lingkungan. Namun demikian, implementasi teknologi ini masih menghadapi tantangan, termasuk keterbatasan infrastruktur, biaya operasional yang tinggi, serta belum adanya regulasi spesifik terkait PhACs di Indonesia. Oleh karena itu, diperlukan pendekatan pengelolaan limbah yang terintegrasi, didukung oleh kebijakan yang adaptif serta adopsi teknologi yang berkelanjutan guna menjamin perlindungan lingkungan dan kesehatan masyarakat
Co-Authors Annur tasya alfiati Nafach Olya Warasky Nor Aida Nor Latifah Raudatul Jannah Sofi agustia putri