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All Journal Indonesian Journal of Pharmaceutical Science and Technology ISTIFHAM
Rahmasari, Yuni
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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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The Development of Nano-mist Spray Propolis as Antioxidant Suryaman, Ine Suharyani; Sulastri, Lela; Rizikiyan, Yayan; Wathoni, Nasrul; Suhandi, Cecep; Noviani, Lusy; Rahmasari, Yuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.52433

Abstract

Propolis is a lipid-based compound from honeybees composed of plant wax, resin, and pollen. Due to its poor water solubility, its application is limited to lipid-based formulations with low bioavailability. This study aimed to develop a water-based propolis nano-mist spray with improved dispersion and evaluate its antioxidant activity. The nano-mist formulation was prepared using soy lecithin and Tween 80 in a phosphate buffer base. Evaluations included organoleptic characteristics, pH, particle size, zeta potential, and antioxidant activity by DPPH method. The propolis extract contained flavonoids, alkaloids, and tannins. The resulting spray showed a light brown color, a pH of 6.87 ± 0.03, particle size of 272.13 ± 4.25 nm, and zeta potential of -0.433 ± 0.35 mV. Antioxidant testing revealed moderate activity with an IC₅₀ value of 83.63 ± 11.88 ppm. This study supports the potential of nano-mist spray as a promising delivery system for propolis with antioxidant properties suitable for cosmetic and pharmaceutical applications.
Co-Authors Abdul Wahab Abdi, Abdul Wahab Afriyani, Mice Putri Lela Sulastri, Lela Nasrul Wathoni Noviani, Lusy Suhandi, Cecep Suryaman, Ine Suharyani Yayan Rizikiyan