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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Indonesian Journal of Pharmaceutical Education
Rosyidah, A’liyatur
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Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Profil dan Potensi Antikanker Ekstrak Etanol 96% Temu Giring (Curcuma heyneana) Pada Sel MCF-7 Misgiati, Misgiati; Andini, Andini; In Oktavia, Anggraeni; Rosyidah, A’liyatur
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28163

Abstract

The use of natural ingredients for cancer treatment is something that needs to be considered to obtain treatment according to the right molecular target cells with high selectivity with minimal side effects. Temu giring (Curcuma heyneana) has the highest antioxidant activity among the rhizome groups; the content of secondary metabolites is polyphenols and flavonoids. There was a correlation between antioxidant activity and cancer activity. The aim of this study was to examine the profile and anticancer activity of MCF-7 cells treated with a 96% ethanol extract of temu giring. Extraction using the maceration method. The profile of temu giring extract uses chemical reactions and thin layer chromatography. Anticancer testing using the Microculture Tetrazolium Technique assay method. Testing using MCF-7 cells with extract concentrations of 400µL, 200µL, 100µL, 50µL, and 25µL. Extract yield: 5.17%. Secondary metabolites in turmeric extract are flavonoids, terpenoids, polyphenols, and anthraquinones. The metabolites have the ability to inhibit MCF-7 cells. The anticancer potential of MCF-7 cells with IC50 60.38±9.03µL (strong cytotoxicity).
OPTIMIZATION OF GREEN SYNTHESIS OF GOLD NANOPARTICLES USING CHILI FRUIT EXTRACTS (Capsicum Sp.) Oktavia, Anggraeni In; Mastuti, Retno; Rosyidah, A’liyatur; Arumingtyas, Estri Laras
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.502

Abstract

The use of plant extracts as reductants in green synthesis of gold metal nanoparticles (AuNPs) requires optimal conditions of temperature, extract concentration and pH. The objective of this research is to identify the optimal synthesis conditions for producing gold nanoparticles (AuNPs). The reducing agents employed are extracts from three varieties of chili peppers: Katokkon, Cakra Hijau, and Paprika Merah. Variations of plant extract concentrations of 10%, 15%, and 20%, incubation temperatures of 25°C, 37.5°C, and 50°C, and pH levels of 5, 7, and 9. The optimization formula design was determined using Box-Behnken, Design Expert version 13.0. The formation of AuNPs was indicated by a change in the color of the solution from yellow to pink to purple. Surface plasmon resonance was observed in the range of 200-800 nm using a microplate reader. Chili, Katokkon, Cakra Hijau and Red Paprika extracts were able to synthesize Au into AuNPs. The optimal formula for synthesizing AuNPs using Katokkon and Red Paprika extracts at a concentration of 10% while Ckra Hijau at a concentration of 15%. The incubation temperature used was 37.5°C for Katokkon extract and 25°C for Cakra Hijau and Red Pepper extract. The pH level used for the synthesis of AuNPs was pH 5 for all chili pepper extracts.
Co-Authors Andini, Andini Anggraeni In Oktavia Estri Laras Arumingtyas In Oktavia, Anggraeni Misgiati, Misgiati Retno Mastuti