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All Journal Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Syaiful, Raisha Hamiddani
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Medicine & Pharmacology

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Uji Efek Analgetik Ekstrak Etanol Kulit Buah Langsat (Lansium domesticum var. pubescens) Secara In Vivo Pertiwi, Hana Retno; Mahdi, Nur; Syaiful, Raisha Hamiddani
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.601

Abstract

Nyeri merupakan perasaan sensitif yang tidak menyenangkan dikarenakan cedera jaringan. Pengobatan nyeri menggunakan tanaman obat sudah banyak dikenal masyarakat salah satunya adalah tanaman langsat (Lansium domesticum var. pubescens). Tujuan penelitian ini adalah untuk mengetahui efek analgetik ekstrak etanol kulit buah langsat (EEKBL) secara in vivo. Metode yang digunakan yaitu eksperimental dan metode Writhing test. Sebanyak 25 ekor mencit digunakan sebagai hewan percobaan, yang dibagi ke dalam lima kelompok: kontrol negatif diberi Na-CMC 0,5%, kontrol positif diberi parasetamol, serta tiga kelompok dosis berbeda, yaitu dosis I (80 mg/kgBB), dosis II (160 mg/kgBB), dan dosis III (240 mg/kgBB). Diamati geliat dan total persen proteksi jumlah geliat dan uji hipotesis menggunakan ANOVA. Hasil persentase proteksi menunjukkan bahwa kontrol positif (parasetamol) sebanyak 39,91% dan untuk ketiga kelompok perlakuan menunjukkan persen proteksi yaitu dosis I sebanyak 34,45%, dosis II sebanyak 47,04%, dan dosis III sebanyak 68,59%. Hasil analisis ANOVA pada semua kelompok perlakuan terdapat perbedaan bermakna (p<0.05). Dapat disimpulkan bahwa EEKBL memiliki efek analgetik dan pada dosis II dan dosis III EEKBL memiliki persen efektivitas analgetik lebih tinggi dari parasetamol yaitu berturut-turut sebesar 117,87% dan 171,86%.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN KASTURI (Mangifera casturi Kosterm) TERHADAP PENURUNAN KADAR ASAM URAT SECARA IN VIVO Mahdi, Nur; Kamaliah, Hajatul; Syaiful, Raisha Hamiddani; Muthia Sari, Okta; Maulana Perdana Putra, Aditya
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2870

Abstract

Gout is a non-communicable disease whose prevalence continues to increase, particularly among the elderly. The treatment using medicinal plants has become widely known to the public, one of which involves kasturi leaves, which are known to contain flavonoids, alkaloids, and tannins that are potentially effective as antihyperuricemic agents. This study aimed to evaluate the effectiveness of extract of kasturi leaves in reducing uric acid levels in Mus musculus. The research employed a true experimental design with a pre-and post-test control group approach. A total of 25 mice were divided into five groups: a negative control group (Na-CMC 1%), a positive control group (allopurinol), and three treatment groups with extract doses of 3 mg/kgBW, 6 mg/kgBW, and 9 mg/kgBW. Hyperuricemia was induced using chicken liver for 7 days. Afterward, the extract was administered for another 7 days, and uric acid levels were measured before and after treatment using the Glucometer tool. The data were analyzed using ANOVA. The results showed that dose 1st reduced uric acid by 21.56%, dose 2nd by 27.15%, and dose 3th by 38.88%. Based on these findings, the ethanol extract of casturi leaves was proven effective in lowering uric acid levels and comparable to allopurinol. Statistically, dose III had a significantly different effect from the negative control and was not significantly different from allopurinol (p> 0.05). It can be concluded that the ethanol extract of casturi leaves at a dose of 9 mg/gBW has the most effective antihyperuricemic activity. The calculated ED50 value was 13.20 mg/gBW.
Co-Authors Kamaliah, Hajatul Maulana Perdana Putra, Aditya Muthia Sari, Okta Nur Mahdi Pertiwi, Hana Retno