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All Journal Sriwijaya Journal of Obstetrics and Gynecology Sriwijaya Journal of Neurology
Saurie Hernandez
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Gut-Brain Axis Dysfunction in Parkinson's Disease: Early Biomarkers and Therapeutic Potential in Jakarta, Indonesia Zahra Amir; Wisnu Wardhana Putra; Linda Purnama; Saurie Hernandez; Adolfo Rawlings; Immanuel Simbolon
Sriwijaya Journal of Neurology Vol. 1 No. 2 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.27

Abstract

Introduction: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. Increasing evidence suggests a crucial role of gut-brain axis dysfunction in PD pathogenesis. This study aimed to investigate the gut microbiome composition, identify potential early biomarkers, and explore the therapeutic potential of targeting the gut-brain axis in PD patients in Jakarta, Indonesia. Methods: This cross-sectional study involved 50 PD patients and 50 age-matched healthy controls from Jakarta. Stool and blood samples were collected for 16S rRNA gene sequencing to analyze gut microbiome composition, and serum inflammatory markers (TNF-α, IL-6, and CRP) were measured using ELISA. Clinical data, including disease duration, severity, and non-motor symptoms, were assessed using standardized scales. Results: PD patients exhibited significant alterations in gut microbiome composition compared to controls, with a decrease in beneficial bacteria (e.g., Faecalibacterium prausnitzii) and an increase in pro-inflammatory bacteria (e.g., Enterobacteriaceae). Elevated levels of serum inflammatory markers were also observed in PD patients. Correlation analysis revealed associations between specific gut microbiota, inflammatory markers, and disease severity. Conclusion: This study provides evidence of gut-brain axis dysfunction in PD patients in Jakarta, Indonesia. Alterations in gut microbiome composition and increased systemic inflammation may serve as potential early biomarkers and therapeutic targets for PD. Further research is needed to explore the causal relationship and develop targeted interventions.
The Impact of Gestational Diabetes on Long-Term Cognitive Function: A Prospective Cohort Study with Neuroimaging Correlates in Bandung, Indonesia Miranda Aisah; Lestini Wulansari; Vania Delma; Reza Andrianto; Zahra Amir; Dedi Sucipto; Agnes Mariska; Saurie Hernandez
Sriwijaya Journal of Neurology Vol. 2 No. 1 (2024): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i2.91

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Introduction: Gestational diabetes mellitus (GDM) is a growing public health concern with potential long-term consequences for both mother and child. Emerging evidence suggests that GDM may impact maternal cognitive function, but the underlying mechanisms remain unclear. This prospective cohort study investigates the association between GDM and long-term cognitive function in mothers, exploring potential neuroimaging correlates. Methods: Pregnant women were recruited from antenatal clinics in Bandung, Indonesia, between 2018 and 2020. GDM was diagnosed using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Cognitive function was assessed at 6 months, 1 year, and 3 years postpartum using a comprehensive neuropsychological battery. A subset of participants underwent structural and functional magnetic resonance imaging (MRI) at 3 years postpartum. Results: Women with GDM exhibited lower scores on tests of executive function, processing speed, and memory compared to women without GDM at all follow-up assessments. MRI analysis revealed alterations in brain structure and function inwomen with a history of GDM, including reduced gray matter volume in the prefrontal cortex and hippocampus, and altered functional connectivity within the default mode network. Conclusion: GDM is associated with long-term cognitive impairment in mothers, possibly mediated by structural and functional brain changes. These findings highlight the importance of early identification and management of GDM to mitigate potential long-term cognitive consequences.
The Prevalence and Risk Factors for Polycystic Ovary Syndrome (PCOS) among Adolescents in Indonesia: Implications for Early Intervention Habiburrahman Said; Rheina Weisch Fedre; Saurie Hernandez; Sophia Lucille Rodriguez; Fatimah Mursyid; Irna Nettles
Sriwijaya Journal of Obstetrics and Gynecology Vol. 2 No. 1 (2024): Sriwijaya Journal of Obstetrics and Gynecology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjog.v1i2.83

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting adolescents, with potential long-term health implications. This study aimed to determine the prevalence and identify risk factors associated with PCOS among Indonesian adolescents. Methods: A cross-sectional study was conducted involving adolescent girls aged 15-19 years from selected schools in Jakarta, Indonesia. Data were collected through questionnaires, physical examinations, and biochemical assessments. PCOS diagnosis was based on the Rotterdam criteria. Logistic regression analysis was used to identify risk factors associated with PCOS. Results: The prevalence of PCOS among Indonesian adolescents was found to be 6.5%. Significant risk factors associated with PCOS included obesity (OR=3.2, 95% CI 2.1-4.8), family history of PCOS (OR=2.5, 95% CI 1.6-3.9), irregular menstrual cycles (OR=4.1, 95% CI 2.8-6.0), and hirsutism (OR=2.8, 95% CI 1.9-4.2). Conclusion: PCOS is prevalent among Indonesian adolescents. Early identification of risk factors such as obesity, family history, irregular menstruation, and hirsutism is crucial for early intervention and management to mitigate potential long-term health consequences.
Co-Authors Adolfo Rawlings Agnes Mariska Dedi Sucipto Fatimah Mursyid Habiburrahman Said Immanuel Simbolon Irna Nettles Lestini Wulansari Linda Purnama Miranda Aisah Reza Andrianto Rheina Weisch Fedre Sophia Lucille Rodriguez Vania Delma Wisnu Wardhana Putra Zahra Amir