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All Journal Pendas : Jurnah Ilmiah Pendidikan Dasar Sriwijaya Journal of Neurology Jejak digital: Jurnal Ilmiah Multidisiplin
Immanuel Simbolon
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Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Social Sciences Other

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Gut-Brain Axis Dysfunction in Parkinson's Disease: Early Biomarkers and Therapeutic Potential in Jakarta, Indonesia Zahra Amir; Wisnu Wardhana Putra; Linda Purnama; Saurie Hernandez; Adolfo Rawlings; Immanuel Simbolon
Sriwijaya Journal of Neurology Vol. 1 No. 2 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.27

Abstract

Introduction: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. Increasing evidence suggests a crucial role of gut-brain axis dysfunction in PD pathogenesis. This study aimed to investigate the gut microbiome composition, identify potential early biomarkers, and explore the therapeutic potential of targeting the gut-brain axis in PD patients in Jakarta, Indonesia. Methods: This cross-sectional study involved 50 PD patients and 50 age-matched healthy controls from Jakarta. Stool and blood samples were collected for 16S rRNA gene sequencing to analyze gut microbiome composition, and serum inflammatory markers (TNF-α, IL-6, and CRP) were measured using ELISA. Clinical data, including disease duration, severity, and non-motor symptoms, were assessed using standardized scales. Results: PD patients exhibited significant alterations in gut microbiome composition compared to controls, with a decrease in beneficial bacteria (e.g., Faecalibacterium prausnitzii) and an increase in pro-inflammatory bacteria (e.g., Enterobacteriaceae). Elevated levels of serum inflammatory markers were also observed in PD patients. Correlation analysis revealed associations between specific gut microbiota, inflammatory markers, and disease severity. Conclusion: This study provides evidence of gut-brain axis dysfunction in PD patients in Jakarta, Indonesia. Alterations in gut microbiome composition and increased systemic inflammation may serve as potential early biomarkers and therapeutic targets for PD. Further research is needed to explore the causal relationship and develop targeted interventions.
A Contrastive Study 0f British and American English Pronunciation for Students Eny Rein Sihombing; Adelia Sidabutar; Immanuel Simbolon; Bloner Sinurat
Jejak digital: Jurnal Ilmiah Multidisiplin Vol. 1 No. 5 (2025): SEPTEMBER
Publisher : INDO PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/4krdmc21

Abstract

English is a language used all around the world, and it has many different ways of being spoken depending on where people are from. The two main ways are British English and American English. These two versions are especially important in schools, media, and international communication. This paper examines the pronunciation differences between British and American English, and how these differences may impact students’ language learning. Rather than conducting experiments, this paper draws upon theories and descriptions from established studies in phonetics and linguistics. The paper focuses on differences in vowels and consonants, how words are stressed, how sentences go up and down in pitch, and processes like rhoticity and flapping. It also gives examples of how these differences show up in classrooms, especially for Indonesian learners who are often exposed to both versions through books, online content, and language learning tools. In the end, the paper suggests that learning pronunciation should focus on making speech clear and understandable, rather than sticking strictly to one way of speaking.
Analisis Miskonsepsi Nilai π pada Materi Lingkaran dalam Buku Senang Belajar Matematika: Antara Nilai Sebenarnya dan Realitas Irasional Syifa Eriza Nasution; Joyce Lidya Patricia Daeli; Pujiono Sihite; Marcelly Claudia Sagala; Immanuel Simbolon; Wingston Leonard Sihombing
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 03 (2025): Volume 10 No. 03 September 2025 Terbit
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i03.33148

Abstract

Understanding mathematical concepts is inseparable from the clarity of their definitions and presentation in textbooks. One fundamental concept that frequently appears in school curricula, from elementary, middle, and high school levels, is the constant π (phi) in the topic of circles. Mathematically, π is an irrational number obtained from the ratio of a circle's circumference to its diameter. However, in practical learning, the value of π is often simplified to or 3.14. This practical presentation has the potential to lead to misconceptions in students, namely, that they assume π is a rational number. This study used qualitative methods with document analysis techniques in the "Happy Learning Mathematics" book. The results of the analysis indicate an emphasis on the use of the value π = or 3.14 without explaining its irrational nature. As a result, students tend to memorize practical formulas and numbers without understanding that these two values are only approximations and that π is an irrational number with infinite decimal places.
Analisis Pedagogis dan Konseptual atas Kesalahan dalam Modul Kalkulus Peubah Banyak: Implikasi untuk Perbaikan Bahan Ajar Immanuel Simbolon; Aghniya Rahmi; Nurul Sakinah; Muhammad Rasyid Mondol; Suwanto
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 04 (2025): Volume 10 No. 04 Desember 2025 Terbit
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i04.36864

Abstract

Penelitian ini bertujuan menganalisis secara pedagogis dan konseptual kesalahan‐kesalahan yang terdapat dalam Modul Pembelajaran Kalkulus Peubah Banyak karya Soebagyo dkk. (2021) dan merumuskan rekomendasi perbaikan bahan ajar. Penelitian menggunakan pendekatan kualitatif dengan jenis studi dokumen melalui kerangka Critical Book Report (CBR). Sumber data utama adalah modul kalkulus peubah banyak yang digunakan pada perkuliahan, sedangkan data pendukung berupa sepuluh artikel jurnal nasional berbahasa Indonesia yang relevan dengan topik kalkulus multivariabel, aljabar linear, dan pendidikan matematika. Dari hasil telaah ditemukan sepuluh kesalahan substantif yang dikategorikan ke dalam: (1) kesalahan definisi dan konsep (fungsi dua peubah, gradien, ortogonalitas, trace matriks), (2) kesalahan prosedural dan perhitungan (proyeksi vektor, contoh segitiga siku-siku, luas segitiga dengan cross product), serta (3) kelemahan notasi dan presentasi simbolik (komponen hasil kali silang, sifat tidak komutatif perkalian matriks, konsistensi notasi matriks). Setiap temuan diverifikasi dengan membandingkan definisi dan teorema baku pada jurnal acuan, kemudian disusun usulan perbaikan berupa redaksi definisi baru, contoh tandingan, penekanan domain-kodomain, serta penambahan latihan konseptual. Hasil penelitian menunjukkan bahwa sebagian kesalahan berpotensi kuat memunculkan miskonsepsi berantai pada topik lanjut (integral lipat, optimasi multivariabel, transformasi linier) sehingga perlu diberi anotasi korektif jika modul tetap digunakan sebagai referensi kuliah. Secara praktis, studi ini memberi masukan bagi dosen, mahasiswa pendidikan matematika, dan pengembang kurikulum mengenai pentingnya audit konseptual terhadap buku ajar kalkulus sebelum digunakan secara luas.
Co-Authors Adelia Sidabutar Adolfo Rawlings Aghniya Rahmi Eny Rein Sihombing Joyce Lidya Patricia Daeli Linda Purnama Marcelly Claudia Sagala Muhammad Rasyid Mondol Nurul Sakinah Pujiono Sihite Saurie Hernandez Sinurat, Bloner Suwanto Syifa Eriza Nasution Wingston Leonard Sihombing Wisnu Wardhana Putra Zahra Amir