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All Journal Sriwijaya Journal of Obstetrics and Gynecology Sriwijaya Journal of Neurology
Miranda Aisah
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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The Impact of Gestational Diabetes on Long-Term Cognitive Function: A Prospective Cohort Study with Neuroimaging Correlates in Bandung, Indonesia Miranda Aisah; Lestini Wulansari; Vania Delma; Reza Andrianto; Zahra Amir; Dedi Sucipto; Agnes Mariska; Saurie Hernandez
Sriwijaya Journal of Neurology Vol. 2 No. 1 (2024): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i2.91

Abstract

Introduction: Gestational diabetes mellitus (GDM) is a growing public health concern with potential long-term consequences for both mother and child. Emerging evidence suggests that GDM may impact maternal cognitive function, but the underlying mechanisms remain unclear. This prospective cohort study investigates the association between GDM and long-term cognitive function in mothers, exploring potential neuroimaging correlates. Methods: Pregnant women were recruited from antenatal clinics in Bandung, Indonesia, between 2018 and 2020. GDM was diagnosed using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Cognitive function was assessed at 6 months, 1 year, and 3 years postpartum using a comprehensive neuropsychological battery. A subset of participants underwent structural and functional magnetic resonance imaging (MRI) at 3 years postpartum. Results: Women with GDM exhibited lower scores on tests of executive function, processing speed, and memory compared to women without GDM at all follow-up assessments. MRI analysis revealed alterations in brain structure and function inwomen with a history of GDM, including reduced gray matter volume in the prefrontal cortex and hippocampus, and altered functional connectivity within the default mode network. Conclusion: GDM is associated with long-term cognitive impairment in mothers, possibly mediated by structural and functional brain changes. These findings highlight the importance of early identification and management of GDM to mitigate potential long-term cognitive consequences.
Social Determinants of Health and Their Influence on Preterm Birth in Rural Indonesian Communities Miranda Aisah; Tomiola Owkwulu; Winata Putri; Theresia Putri Sinaga; Syaifudin Syaifudin; Reza Andrianto
Sriwijaya Journal of Obstetrics and Gynecology Vol. 1 No. 2 (2023): Sriwijaya Journal of Obstetrics and Gynecology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjog.v1i1.22

Abstract

Introduction: Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, is a major contributor to neonatal mortality and morbidity globally, with a disproportionate burden in low-resource settings like rural Indonesia. This study aimed to investigate the influence of social determinants of health (SDOH) on PTB in rural Indonesian communities. Methods: A retrospective cohort study was conducted using data from the Indonesian Maternal and Perinatal Health Survey (IMPHS) 2018-2021. A total of 15,480 women residing in rural areas with singleton pregnancies were included. SDOH variables examined included maternal education, socioeconomic status (SES), access to healthcare, and geographical remoteness. Multivariable logistic regression analysis was performed to assess the association between SDOH and PTB, adjusting for potential confounders. Results: The prevalence of PTB in the study population was 12.3%. Lower maternal education, lower SES, limited access to healthcare, and residing in remote areas were significantly associated with increased odds of PTB. Women with no formal education had 2.1 times higher odds of PTB compared to those with higher education (adjusted odds ratio [aOR] 2.1, 95% CI 1.8-2.5). Similarly, women in the lowest SES quintile had 1.8 times higher odds of PTB compared to the highest quintile (aOR 1.8, 95% CI 1.5-2.2). Conclusion: SDOH significantly influence PTB in rural Indonesian communities. Addressing these social inequities through targeted interventions, such as improving access to education, healthcare, and economic opportunities, is crucial for reducing the burden of PTB and improving maternal and child health outcomes.
Predicting Meningioma Risk: The Role of Hormone-Related Molecular Markers and Intracellular Signaling Pathways Sari Sulistyoningsih; Miranda Aisah; Utter Prakesh; Bryan Helsey
Sriwijaya Journal of Neurology Vol. 3 No. 1 (2025): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v2i2.185

Abstract

Introduction: Meningiomas are common intracranial tumors with an established association with hormonal factors. This study aimed to comprehensively evaluate the predictive value of hormone-related molecular markers and their associated intracellular signaling pathways in meningioma development. Methods: A retrospective case-control study was conducted, including 200 patients with histologically confirmed meningioma (cases) and 200 age- and gender-matched controls. Tumor tissue and serum samples were analyzed for the expression of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), and growth hormone receptor (GHR) using western blot and ELISA, respectively. The activation status of the PI3K/AKT/mTOR and MAPK/ERK signaling pathways was assessed by analyzing the levels of phosphorylated proteins in the pathways. Results: Elevated expression of ER, PR, and GHR was observed in the tumor tissue of meningioma cases compared to controls (p<0.05). Serum levels of ER and PR were also significantly higher in cases. Analysis of signaling pathways revealed increased activation of both PI3K/AKT/mTOR and MAPK/ERK pathways in meningioma cases. Multivariate analysis confirmed that ER and PR expression, both in tumor tissue and serum, were independent predictors of meningioma risk, along with age and female sex. Conclusion: Our findings suggest that ER, PR, and GHR may serve as potential predictive markers for meningioma risk. The involvement of PI3K/AKT/mTOR and MAPK/ERK signaling pathways further underscores the complex interplay between hormonal factors and intracellular signaling in meningioma development. These findings may contribute to improved risk assessment and the development of targeted therapeutic strategies for meningiomas.
Co-Authors Agnes Mariska Bryan Helsey Dedi Sucipto Lestini Wulansari Reza Andrianto Sari Sulistyoningsih Saurie Hernandez Syaifudin Theresia Putri Sinaga Tomiola Owkwulu Utter Prakesh Vania Delma Winata Putri Zahra Amir