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All Journal Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana)
Muzaki, Yoga Adi Restu
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Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Therapeutic Synergy of Combination of Kaempferia galanga and Zingiber officinale Extracts on Hyperuricemia-Induced Arterial Stiffness Hasimun, Patonah; Muzaki, Yoga Adi Restu; Sodik, Jajang Japar; Sukmawati, Ika Kurnia; Kusriani, Herni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.59175

Abstract

Hyperuricemia, characterized by high uric acid levels, is associated with an elevated risk of cardiovascular diseases. Xanthine oxidoreductase (XOR), an enzyme central to uric acid generation, is implicated in oxidative stress and diminished vascular function. It has become a focal point for potential therapeutic interventions. This investigation aimed to assess the influence of combined ethanol extracts of Kaempferia galanga L. and Zingiber officinale (KGZE) on xanthine oxidase activity and arterial rigidity in hyperuricemic rat models. Furthermore, the research sought to explore these extracts' potential in managing hyperuricemia and its associated vascular disorders. Hyperuricemia was established in Wistar rats by administering potassium oxonate at 4.5 mg/kg via injection. A total of 25 rats were divided into five groups: a normal control group receiving 0.5% CMC, a positive control group with hyperuricemia, a reference group treated with allopurinol (1.8 mg/kgBW), and two experimental groups receiving KGZE at doses of 50 mg/kgBW and 100 mg/kgBW. All rats consumed 25% fructose in their drinking water for 28 days. This study measured uric acid levels and arterial stiffness, revealing that KGZE significantly reduced uric acid levels and improved arterial stiffness, indicating its potential as an XOR inhibitor.
Therapeutic Potential of Kaempferia galanga L. Extract in Ameliorating Oxidative Stress and Metabolic Dysregulation in a Rat Model of Metabolic Syndrome Hasimun, Patonah; Muzaki, Yoga Adi Restu; Sukmawati, Ika Kurnia; Zahra, Nadhira Aulia; Kusriani, Herni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.60514

Abstract

Metabolic syndrome is associated with an increased risk of hypertension, diabetes, and cardiovascular disease, which are often triggered by oxidative stress and inflammation. This study evaluated the effects of Kaempferia galanga L extract (ERK) on oxidative stress and metabolic dysfunction using a fructose-induced male Wistar rat model. A total of 25 rats were divided into five groups: normal control, positive control, allopurinol group, and two ERK treatment groups at doses of 50 and 100 mg/kg body weight. All groups, except the normal control, were given 25% fructose in the drinking water and an injection of potassium oxonate (4.5 mg/kg body weight) for 28 days. Evaluation was done by measurement of glucose, triglyceride, malondialdehyde (MDA) and nitric oxide (NO) and histological analysis of aortic tissue. The results showed that ERK, especially at a dose of 100 mg/kg, significantly reduced glucose, triglyceride and MDA levels and increased NO levels. ERK administration also reduced the body weight of mice and prevented the formation of foam and inflammatory cells in aortic tissue. The total flavonoid content of ERK also supports its biological activity. This study concludes that ERK has potential as a natural therapeutic agent to treat metabolic syndrome through antioxidant and anti-inflammatory mechanisms.
Co-Authors Hasimun, Patonah Roseno, Mohammad Sodik, Jajang Japar Sukmawati, ika kurnia Widyastiwi Zahra, Nadhira Aulia