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All Journal KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Muhammadiyah Medical Journal Cerdika: Jurnal Ilmiah Indonesia Cermin Dunia Kedokteran
Ilmiawan, Muhammad In’am
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Protective Effect of Combination Black Seed Oil (Nigella sativa) and Honey on the Duodenum of Rats Exposed to Cisplatin Wasilah, Khusnul; Ilmiawan, Muhammad In’am; Handini, Mitra
Muhammadiyah Medical Journal Vol 4, No 1 (2023): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.4.1.8-14

Abstract

Background: Cisplatin (CP) is an anticancer agent with various side effects, including duodenal mucosal damage. It is well known that black seed oil (BSO) and honey (H) are rich in antioxidants and have a mucosal protective effect. Purposes: To determine the protective effect of the BSO and H combination on the histopathology of duodenal rats given CP exposure. Methods: Randomized post-test-only control group design was used in this study. A total of 30 rats were divided into ten groups, namely the control group (K), treatment groups (P1-P8), and cisplatin group (C). The treatment groups were given BSO and H orally for 21 days, and CP was given intraperitoneally on day 18 to the treatment and cisplatin groups. On day 22, the duodenal tissue was taken for preparation and histopathological assessment. Data analysis using IBM SPSS v.24 and Compusyn program. Result: There were significant differences in the duodenal mucosa damage scores of the P1-P8 group compared to the C group (p0.05). The combination index of P7 exerted a synergism effect (CI 1). Conclusion: The combination of BSO and H exerted a protective effect on the histopathological of rats’ duodenal tissue induced with CP, and the combination of BSO 2 mL/KgBW and H 3.7 mL/KgBW exerted a synergism effect.
THE EFFECT OF SINGLE- AND REPEATED- EXCESSIVE SWIMMING EXERCISE ON KIDNEY HISTOPATHOLOGY OF MALE RATS WISTAR STRAIN (Rattus norvegicus) Tripani, Wenni Juniarni; Ilmiawan, Muhammad In’am; Handoko, Willy
Muhammadiyah Medical Journal Vol 1, No 1 (2020): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (778.278 KB) | DOI: 10.24853/mmj.1.1.33-42

Abstract

Background: Physical exercise aims to improve or maintain physical fitness. However, excessive physical exercise may cause increase of oxidative stress which leads to cellular injury, including in the proximal tubules of kidney. This research aims to find out the effect of single- and repeated- excessive swimming exercise to the kidney histopathology of male wistar rats (Rattus norvegicus). Methods: This research was an experimental study with complete random and post test only control group design. Twenty seven male wistar rats were divided into three treatment groups: control group, single- excessive swimming exercise group (45 minutes for one day), and repeated- excessive swimming exercise group (45 minutes/day for seven days). In the end of the treatment, the kidney of the rats were taken to be analyzed by using hematoxylin-eosin stain. The mean of proximal tubules injury of kidneys were counted by two observers using blinded method. Data were analyzed by using one way anova test. Result: The analysis showed there was a significant difference in the mean percentage of proximal tubules injury between control group and single swimming group as well as the repeated swimming group (Anova p=0,000), also there was significant difference between the treatment groups (p=0,020). The highest average of proximal tubules injury was in the single swimming group. Conclusion: Single- and repeated- excessive swimming exercise causes the proximal tubules injury of kidney.
Efek Andrographolide terhadap Gambaran Histopatologi Sel Hepar Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Karbon Tetraklorida (CCl4): Hasil Penelitian Sanjaya, Vincent; Andriani; Ilmiawan, Muhammad In’am
Cermin Dunia Kedokteran Vol 52 No 10 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i10.1010

Abstract

Introduction: Andrographolide is a group of diterpene lactone isolates from the Andrographis paniculata plant with hepatoprotective properties. Andrographolide gives a hydrogen ion to pair with a free electron from a free radical to form a stable chemical compound and thus decrease liver damage. Methods: This experimental research used a post-test only with a control group design. The samples were mouse's liver (Rattus norvegicus).Twenty-four mice (Rattus norvegicus) were divided into 6 groups: a normal group, a curcumin-treated group as a positive control, a carbon tetrachloride-only group as a negative control, and the treatment group with the dose an andrographolide 50 mg/kgBW group, an andrographolide 100 mg/kgBW group, and an andrographolide 200 mg/kgBW group with 4 mice in each group. Mice were induced with carbon tetrachloride on the first day, then treated with curcumin and andrographolide for 7 days. Liver organs were dissected on day 9 to prepare a specimen for assessing hepatocyte damage (necrosis and hydropic degeneration). Results: Andrographolide showed a hepatoprotective effect on hepatocyte damage after induction by CCl4. The injury score in the normal group is 16.84; the negative control group is 34.36; the positive control group is 11.48; the dose 1 group is 24.92; the dose 2 group is 19.96; and dose 3 is 19.52. In the LSD test, the 50 mg/kgBW and 100 mg/kgBW andrographolide dose groups showed significant differences in hepatocyte damage compared to the normal group. There was no significant difference in liver histopathologic injury score between the normal group and the andrographolide 200 mg/kgBW group (ANOVA, p > 0.05). Conclusion: The best hepatoprotective effect was provided by andrographolide 200 mg/kgBW because the degree of damage is similar to that in the normal group.
A UJI MIKROBIOLOGIS KELAYAKAN MINUMAN ES JERUK PERAS PINGGIR JALAN PONTIANAK TENGGARA Marizca Okta Syafani; Mahyarudin; Ilmiawan, Muhammad In’am
KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Vol 8 No 2 (2022): December
Publisher : Universitas Widya Gama Mahakam Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24903/kujkm.v8i2.1526

Abstract

Background: Squash orange squash is a natural drink with the ingredients consist of ice and oranges that are sold in many places such as eatery and vendor. Iced orange squash might not be safe for consumption because bad quality oranges, unclean water, unhygienic sellers, and unstandarlized environmental sanitation of the beverage processing. These could cause indigestion with the symptoms of nausea, stomachache, vomitting and diarrhea. The bacteria often used as the indicator that causes contamination in the beverage is Coliform, for example Escherichia coli. Objectives: To find out about the food safety of iced orange squash in Southeast Pontianak. Research Metodes: This research is descriptive with cross-sectional approach. This research uses bacterial quantification method with Most Probable Number (MPN) as the technique and purposive sampling as the sampling method. Results: This research indicates that 16 samples of Squeezed Orange ice exceed the maximum microbial limit that is with the value range of 20 MPN/100 ml - >1100 MPN/ 100 ml contaminated with Coliform (100%) and Escherichia coli (100%). Conclusion: The tested iced orange squash drinks are not safe to consume and unstandardized according to Permenkes 2010, National Standard of Indonesia and World Health Organization.
EFEK PROTEKTIF EKSTRAK ETANOL UMBI BAWANG DAYAK TERHADAP DIAMETER DAN VOLUME TUMOR PAYUDARA TIKUS PUTIH RATTUS NORVEGICUS BETINA GALUR SPRAGUE-DAWLEY DIINDUKSI 7,12-DIMETHYLBENZ(?)ANTHRACENE Elshaddayana Sitompul, Sonia; Ilmiawan, Muhammad In’am; Pratiwi, Sari Eka
Cerdika: Jurnal Ilmiah Indonesia Vol. 3 No. 10 (2023): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v3i10.697

Abstract

Bawang dayak (Eleutherine bulbosa) merupakan tanaman herbal yang dipercaya masyarakat Indonesia memiliki efek anti kanker. Bawang dayak memiliki kandungan triterpenoid, flavonoid, antrakuinon dan naftokuinon yang memiliki aktivitas biologis sebagai antioksidan dan antikanker. Penelitian ini bertujuan untuk mengetahui efek daya hambat ekstrak etanol umbi bawang dayak (Eleutherine bulbosa) terhadap pertumbuhan jaringan tumor payudara secara makroskopis. Jenis penelitian ini adalah penelitian eksperimental dengan desain posttest-only control group. Penelitian menggunakan 30 tikus betina galur Sprague Dawley, dibagi secara acak menjadi 6 kelompok, yaitu kelompok normal, kelompok kontrol positif (tamoxifen), kelompok kontrol negatif (DMSO 5%), kelompok perlakuan I (ekstrak umbi bawang dayak 180 mg/kg BB), kelompok perlakuan II (ekstrak umbi bawang dayak 360 mg/kg BB) dan kelompok perlakuan III (ekstrak umbi bawang dayak 720 mg/kg BB). Hasil penelitian ini didapatkan data diameter tumor dan volume tumor dianalisis menggunakan program SPSS dengan One-way ANOVA dan Post hoc LSD. Ekstrak etanol umbi bawang dayak berbeda bermakna (p<0,05) dalam penghambatan pertumbuhan diameter dan volume tumor payudara. Hasil uji Post Hoc LSD menunjukkan bahwa terdapat perbedaan signifikan antar kelompok perlakuan I, II dan III terhadap kelompok kontrol negatif. Penelitian ini menyimpulkan ekstrak etanol umbi bawang dayak mempunyai daya hambat terhadap diameter dan volume tumor payudara
Co-Authors Andriani Elshaddayana Sitompul, Sonia Handini, Mitra Handoko, Willy Mahyarudin, Mahyarudin Marizca Okta Syafani Sanjaya, Vincent Sari Eka Pratiwi Tripani, Wenni Juniarni Wasilah, Khusnul