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All Journal KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Muhammadiyah Medical Journal Cerdika: Jurnal Ilmiah Indonesia Cermin Dunia Kedokteran
Ilmiawan, Muhammad In’am
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Muhammadiyah Medical Journal

 1 
Protective Effect of Combination Black Seed Oil (Nigella sativa) and Honey on the Duodenum of Rats Exposed to Cisplatin Wasilah, Khusnul; Ilmiawan, Muhammad In’am; Handini, Mitra
Muhammadiyah Medical Journal Vol 4, No 1 (2023): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.4.1.8-14

Abstract

Background: Cisplatin (CP) is an anticancer agent with various side effects, including duodenal mucosal damage. It is well known that black seed oil (BSO) and honey (H) are rich in antioxidants and have a mucosal protective effect. Purposes: To determine the protective effect of the BSO and H combination on the histopathology of duodenal rats given CP exposure. Methods: Randomized post-test-only control group design was used in this study. A total of 30 rats were divided into ten groups, namely the control group (K), treatment groups (P1-P8), and cisplatin group (C). The treatment groups were given BSO and H orally for 21 days, and CP was given intraperitoneally on day 18 to the treatment and cisplatin groups. On day 22, the duodenal tissue was taken for preparation and histopathological assessment. Data analysis using IBM SPSS v.24 and Compusyn program. Result: There were significant differences in the duodenal mucosa damage scores of the P1-P8 group compared to the C group (p0.05). The combination index of P7 exerted a synergism effect (CI 1). Conclusion: The combination of BSO and H exerted a protective effect on the histopathological of rats’ duodenal tissue induced with CP, and the combination of BSO 2 mL/KgBW and H 3.7 mL/KgBW exerted a synergism effect.
THE EFFECT OF SINGLE- AND REPEATED- EXCESSIVE SWIMMING EXERCISE ON KIDNEY HISTOPATHOLOGY OF MALE RATS WISTAR STRAIN (Rattus norvegicus) Tripani, Wenni Juniarni; Ilmiawan, Muhammad In’am; Handoko, Willy
Muhammadiyah Medical Journal Vol 1, No 1 (2020): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (778.278 KB) | DOI: 10.24853/mmj.1.1.33-42

Abstract

Background: Physical exercise aims to improve or maintain physical fitness. However, excessive physical exercise may cause increase of oxidative stress which leads to cellular injury, including in the proximal tubules of kidney. This research aims to find out the effect of single- and repeated- excessive swimming exercise to the kidney histopathology of male wistar rats (Rattus norvegicus). Methods: This research was an experimental study with complete random and post test only control group design. Twenty seven male wistar rats were divided into three treatment groups: control group, single- excessive swimming exercise group (45 minutes for one day), and repeated- excessive swimming exercise group (45 minutes/day for seven days). In the end of the treatment, the kidney of the rats were taken to be analyzed by using hematoxylin-eosin stain. The mean of proximal tubules injury of kidneys were counted by two observers using blinded method. Data were analyzed by using one way anova test. Result: The analysis showed there was a significant difference in the mean percentage of proximal tubules injury between control group and single swimming group as well as the repeated swimming group (Anova p=0,000), also there was significant difference between the treatment groups (p=0,020). The highest average of proximal tubules injury was in the single swimming group. Conclusion: Single- and repeated- excessive swimming exercise causes the proximal tubules injury of kidney.
Co-Authors Andriani Elshaddayana Sitompul, Sonia Handini, Mitra Handoko, Willy Mahyarudin, Mahyarudin Marizca Okta Syafani Sanjaya, Vincent Sari Eka Pratiwi Tripani, Wenni Juniarni Wasilah, Khusnul