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All Journal Belitung Nursing Journal Sumatera Medical Journal Jurnal Farmasi Indonesian Journal of Pharmacology and Therapy
Probosuseno
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effect of Mean Platelet Volume on Outcome of Stroke Infark in Elderly Patient Dalimunthe, Anita Rosari; Probosuseno; Putu Pramantara, I Dewa
Sumatera Medical Journal Vol. 8 No. 1 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i1.8254

Abstract

Background: Hyperreactivity and activation of platelet play a role in the occurrence and severity of ischemic stroke in geriatric patients. Mean Platelet Volume (MPV) describes levels of stimulation as well as platelet production rates that may affect the incidence of ischemic stroke and its clinical outcome. Objective: To determine the effect of MPV on the outcome of stroke infarction in geriatric patients. Methods: This was a cohort study. MPV measured at hospital admission. Statistical analysis carried out by Receiver of Curve (ROC) test to determine the MPV cut off point and Chi-square to determine the relationship between MPV and infarction of stroke patient using SPSS v.22. Results: There were 52 stroke patients with mean age 68.25+6.06 years. Clinical outcomes   deteriorated in 38 (73.08%) patients. The AUC value of MPV was 73.3% (p=0.011) with MPV cut off point 10.85fl. Deterioration occurred in 10 (43.38%) patient with MPV >10.85fl. The Chi-square test result was (p<0.001) showing a difference between the groups (RR 3.125 CI 95% 1.134-8.761). Conclusion: Ischemic stroke patients with MPV levels >10.85fl at hospital admission had 3 times chance of deterioration. MPV can be used as prognostic factor for clinical outcome of acute ischemic stroke in geriatric patients.
Evaluating a caregiver-focused safety culture model: Effects on caregivers’ safety perception, older adults’ quality of life, and the incidence of adverse events in Indonesia Solihin, Asri Handayani; Probosuseno; Effendy, Christantie
Belitung Nursing Journal Vol. 11 No. 5 (2025): September - October
Publisher : Belitung Raya Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33546/bnj.3650

Abstract

Background: Older adults are increasingly vulnerable to health risks, particularly in home care environments with limited formal safety measures. In Indonesia, family caregivers play a central role in providing care; however, research on interventions to enhance the safety of older adults at home remains limited. Objectives: This study aimed to evaluate the impact of a caregiver-focused safety model, the Aging Safe from the Risk (ASRi) model, on caregivers’ perceptions of safety culture and assessed its indirect effects on older adults’ quality of life (QoL) and incidence of adverse events. Methods: A quasi-experimental study was conducted from July to November 2022, involving 135 older adult–caregiver pairs (intervention: n = 68; control: n = 67). Older adults’ QoL was measured using the modified WHO-QOL BREF (Indonesian version) and WHO-QOL OLD instruments. Family caregivers completed a Home Safety Culture (HSC) questionnaire and reported adverse events. Data were analyzed using descriptive statistics, chi-square tests, independent t-tests, Mann–Whitney U tests, Fisher’s exact tests, repeated-measures general linear models (GLM-RM), and exploratory ANCOVA within the intervention group. Results: Baseline characteristics were largely similar for older adults (age, comorbidities, fall risk, medication use) and caregivers (gender, age, education, marital status), although some imbalances were noted. Significant between-group differences were observed in the spiritual dimension (baseline p = 0.019, r = 0.202; fourth month p = 0.018, r = 0.204) and environmental dimension of safety culture (all time points p <0.001, r = 0.347-0.431), with a transient difference in the personal dimension at month one (p = 0.013, r = 0.215). QoL scores were consistently higher in the control group (p <0.001, Cohen’s d = 0.551-0.645), reflecting baseline imbalance. Adverse events decreased in the intervention group during follow-up (p <0.001, Cramér’s V = 0.343-0.364); however, the higher baseline incidence suggests that regression to the mean may have contributed to this reduction. Conclusion: The ASRi model was associated with modest improvements in caregivers’ perceptions of safety culture. Differences in QoL and adverse events should be interpreted cautiously due to baseline imbalances and potential regression to the mean. While these findings provide preliminary indications that caregiver engagement through the ASRi model may support safer home care practices, causal conclusions cannot be drawn. Randomized studies with longer follow-up are needed to confirm these effects. Trial Registry: NCT05487482 [clinicaltrials.gov]
EVALUASI PENGARUH KESESUAIAN TERAPI HIPERTENSI DENGAN GUIDELINE JNC 7 TERHADAP TERCAPAINYA TARGET TEKANAN DARAH PASIEN DI RS PANTI WALUYO SURAKARTA PERIODE JANUARI-DESEMBER 2013 Dian Anggraini, Truly; Puspita Sari, Ika; Probosuseno
Jurnal Farmasi (Journal of Pharmacy) Vol. 5 No. 1 (2016): Jurnal Farmasi (Journal of Pharmacy), October 2016
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Hypertension is a major public health problem worldwide and is the most common risk factor for cardiovascular disease. The prevalence of hypertension in the population aged 18 years and above at 29.8%. Epidemiological data indicates that an increase of blood pressure would improve cardiovascular events. Therefore, hypertension should be treated appropriately by controlling blood pressure. This research aims to evaluate the effect of appropriateness of therapy hypertension based on JNC7 guideline in order to gain targeted blood pressure in RS Panti Waluyo Surakarta during January-December 2013. This study conducted using cohort retrospectively in inpatients medical record in RS Panti Waluyo Surakarta. A total of 116 samples were analyzed with descriptive-analytic method. Both monotherapy and combination of anti-hypertension drug were analyzed with JNC 7 guideline while the target blood pressure were statistically analized using Chi-square test. This research result showed that 50 patients exhibited the appropriate anti-hypertension therapy, while 66 patients showed the inappropriate anti-hypertension therapy. The pattern of anti-hypertension was that 38 patients prescribed single anti-hypertension medicine, 34 patients prescribed combination of 2 anti-hypertension medicine. Like the patients in appropriate group (66%), there were (47%) patients in inappropriate group could achive the target of blood pressure. In conclusion, there is a significant relationship between appropriateness of anti-hypertension use and target blood pressure (p <0.05).
Comparison of the effectiveness and safety between gabapentin and amitriptyline in pain improvement in peripheral diabetic neuropathy patients: a review Rachmania, Nindita; Probosuseno; Fita Rahmawati
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.10307

Abstract

Neuropathy pain is one chronic pain that is difficult to treat and has not had an ideal curative therapy, yet. Gabapentin and amitriptyline are widely used as diabetic neuropathy therapies. However, their effectiveness is still debatable and their side effect has been reported. Several factors affect the efficacy and morbidity of gabapentin and amitriptyline in diabetic neuropathy patients. Some treatment options for diabetic neuropathy are available in clinical setting, therefore evaluation the effectiveness of the treatment options is needed to choose the best treatment. This review article evaluated the effectiveness and safety between gabapentin and amitriptyline as pain relief in peripheral diabetic neuropathy (PDN) patients. It was a narrative review using electronic databases such as Science Direct, Scopus and PubMed. The results showed that effectiveness and safety of gabapentin is better than amitriptyline in relief pain on PDN.
Co-Authors Christantie Effendy Dalimunthe, Anita Rosari Dian Anggraini, Truly Fita Rahmawati Puspita Sari, Ika Putu Pramantara, I Dewa Rachmania, Nindita Solihin, Asri Handayani