Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Merdeka Indonesia Jurnal International Pharmacy Reports
Aprilia, Vika
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Evaluation of natural compounds as VEGFR-2 inhibitors for breast cancer therapy: insights from molecular docking and drug-likeness analysis Aprilia, Vika; Sarmoko; Fareza, Muhamad Salman; Baroroh, Hanif Nasiatul; Choironi, Nur Amalia
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.82

Abstract

Breast cancer remains one of the most common cancers worldwide, with VEGFR-2 (KDR) playing a key role in tumor angiogenesis. Inhibiting VEGFR-2 is a promising therapeutic strategy. Natural compounds are increasingly studied for their potential to inhibit VEGFR-2. This study aims to assess the binding affinity of 11 natural compounds (andrographolide, alpha-mangostin, pinostrobin, pinocembrin, ethyl-p-methoxycinnamate (EPMS), xanthorrhizol, galangin, gamma-mangostin, curcumin, cinnamaldehyde, and alashanoid B) to the VEGFR-2 protein through molecular docking and Lipinski's rule analysis, identifying promising candidates for breast cancer treatment. Molecular docking simulations were performed for 11 compounds and sunitinib as a control, with binding energies and interactions analyzed. The compounds were also evaluated for drug-likeness using Lipinski’s rule of five. Curcumin showed the highest binding affinity to VEGFR-2 with a binding energy of -9.9 kcal/mol, surpassing sunitinib (-9.4 kcal/mol). Key interactions were observed with active site residues Cys919 and Asp1046. All tested compounds met the criteria for oral bioavailability per Lipinski’s rules. Curcumin demonstrates potential as a VEGFR-2 inhibitor due to its favorable binding affinity and drug-like properties. Enhancing curcumin’s bioavailability is recommended for effective therapeutic application.
IMPLEMENTASI STRATEGI PEMBELAJARAN COLLECT POINT PADA MATA PELAJARAN SEJARAH KEBUDAYAAN ISLAM DI MTS MA’ARIF NU 1 PURWOKERTO Aprilia, Vika; Sunhaji
Merdeka Indonesia Jurnal International Vol 5 No 1 (2025): Vol 5 No 1 (2025): MIJI : Merdeka Indonesia Journal International
Publisher : Merdeka Indonesia Jurnal International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69796/miji.v5i1.344

Abstract

Dalam pembelajaran sejarah kebudayaan Islam (SKI), guru dituntut untuk menyajikan materi dengan cara yang menarik dan efektif. Namun, di MTs Ma’arif NU 1 Purwokerto masih ditemukan kendala anggapan bahwa mata pelajaran SKI membosankan yang berdampak pada rendahnya motivasi belajar siswa. Untuk mengatasi hal tersebut, sejak tahun 2023 guru menerapkan strategi pembelajaran collect point sebagai inovasi guna meningkatkan semangat, motivasi, dan partisipasi aktif siswa dalam proses pembelajaran. Penelitian ini bertujuan untuk mendeskripsikan implementasi strategi pembelajaran collect point pada mata pelajaran sejarah kebudayaan Islam di MTs Ma’arif NU 1 Purwokerto. Penelitian ini merupakan jenis penelitian lapangan dengan menggunakan pendekatan metode kualitatif deskriptif. Teknik pengumpulan data dengan cara observasi, wawancara dan dokumentasi. Proses Analisis data dilakukan dengan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian yang diperoleh mencangkup penerapan strategi pembelajaran collect point pada mata pelajaran sejarah kebudayaan Islam di MTs Ma’arif NU 1 Purwokerto terbagi menjadi tiga tahapan, perencanaan, penerapan yang meliputi tahap pembuka, tahap inti dan tahap penutup, dan evaluasi. Penerapan strategi pembelajaran collect point tak hanya berdampak positif terhadap suasana pembelajaran tetapi juga pada keaktifan siswa dalam kegiatan pembelajaran.
Co-Authors Fareza, Muhamad Salman Hanif Nasiatul Baroroh Nur Amalia Choironi Sarmoko Sarmoko Sunhaji