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All Journal Jurnal Buana Farma Media Farmasi Indonesia
Putik Titian Citra Hening
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other

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Formulation and Characteristics of Hydrogel Patch Containing Pineapple Peel (Ananas comosus L.) Ethanol Extract Anisah Putri Yuana Sari; Putik Titian Citra Hening; Marshanda Nikita; Ahmad Maulana Al Fatah; Fajrina Rizqi Riyadi; Ihsanti Dwi Rahayu
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.296

Abstract

Abstract Pineapple peel (Ananas comosus L.) contains bioactive compounds such as flavonoids and the enzyme bromelain, which possess antioxidant, anti-inflammatory, antibacterial, and anticancer properties, and the ability to accelerate wound healing. Hydrogel patches, as a formulation for transdermal delivery, are effective in wound healing due to their hydrophilic properties that maintain moisture and prevent bacterial infection in open wounds. This study aims to develop and test the characteristics of hydrogel patch formulations containing ethanol extracts of pineapple peel with varying concentrations of 10%, 20%, and 30%, compared to a control (hydrogel patch without pineapple peel extract). A series of evaluation tests were conducted to assess the patch characteristics, including organoleptic tests, pH, absorbency, weight uniformity, swelling ratio, patch thickness, and folding endurance. The results showed that the concentration of pineapple peel extract affects the hydrogel patch characteristics. The higher the extract concentration, the darker the patch color, but the pH, absorbency, and swelling ratio decrease. Patches with higher extract concentrations also showed an increase in weight. Absorbency tests indicated that none of the formulas met the acceptance criteria (<10%), with absorbency results of 22.97%, 11.60%, and 21.95% for 10%, 20%, and 30% extract concentrations, respectively, and 23.43% for the control. Swelling ratio and thickness tests showed the best results for the control, followed by the 10%, 20%, and 30% extract concentrations. The folding endurance test showed that the control and 10% extract formula had good results (>300 folds), while higher extract concentrations reduced the folding endurance of the hydrogel patch .Keywords: extract, pineapple peel, hydrogel patch, formulation, patch characteristics
Development of Pineapple Skin Extract Hydrogel Patch Applications (Ananas comosus L.) as Wound Dressing in Diabetic Ulcers in Mice (Mus musculus) Putik Titian Citra Hening; Anisah Putri Yuana Sari; Marshanda Nikita; Ahmad Maulana Al Fatah; Fajrina Rizqi Riyadi; Ihsanti Dwi Rahayu
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.297

Abstract

Abstrak Diabetes melitus merupakan penyakit gangguan metabolisme kronis yang disebabkan oleh tingginya kadar glukosa darah. Salah satu komplikasi yang sering terjadi pada penderita diabetes melitus adalah ulkus diabetikum. Penelitian menunjukkan bahwa kulit nanas mengandung flavonoid, yaitu senyawa aktif yang bersifat antiinflamasi dan antimikroba, yang dapat mempercepat penyembuhan luka. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian patch hidrogel yang mengandung ekstrak kulit nanas (Ananas comosus L.) sebagai pembalut luka pada tikus putih (Mus musculus) jantan yang mengalami ulkus diabetikum. Penelitian ini melibatkan beberapa tahap, meliputi ekstraksi kulit nanas, pembuatan patch hidrogel, uji aktivitas antibakteri, dan pemberian patch hidrogel pada hewan uji. Penelitian ini menggunakan 20 ekor tikus putih jantan galur Deutschland Denken Yoken (DDY) yang dibagi menjadi 5 kelompok. Kelompok kontrol negatif mendapat patch hidrogel tanpa ekstrak, sedangkan kelompok kontrol positif mendapat Winner Hydrocolloid Dressing. Kelompok perlakuan I, II, dan III masing-masing diberi patch hidrogel dengan ekstrak kulit nanas 10%, 20%, dan 30%. Hasil penelitian menunjukkan bahwa plester hidrogel dengan ekstrak kulit nanas mempercepat penyembuhan luka pada model ulkus diabetik. Uji aktivitas antibakteri menunjukkan aktivitas antimikroba yang signifikan terhadap Staphylococcus aureus, yang umum ditemukan pada ulkus diabetik. Aplikasi plester hidrogel mengurangi peradangan dan memperbaiki struktur jaringan kulit pada hewan uji, menunjukkan potensi plester hidrogel ekstrak kulit nanas sebagai pembalut luka alternatif yang efektif untuk ulkus diabetik. Kata kunci: ulkus diabetikum, ekstrak kulit nanas, patch hidrogel, pembalut luka
PENGARUH PERBANDINGAN FASE GERAK PADA ANALISIS DEKSAMETASON MENGGUNAKAN HPLC : NARRATIVE REVIEW Hening, Putik Titian Citra; Rahayu, Ihsanti Dwi; Iqbal, Muhammad; Triyandi, Ramadhan
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1561

Abstract

Dexamethasone is a synthetic glucocorticoid widely used in the treatment of inflammatory, allergic, and autoimmune diseases; therefore, accurate analytical methods are required to ensure its quality and safety. High Performance Liquid Chromatography (HPLC) is an analytical technique that is currently widely applied due to its high sensitivity, selectivity, and reliability for pharmaceutical analysis. In HPLC method development, the selection of the mobile phase can significantly influence separation quality, resolution, column efficiency, retention time, sensitivity, and analytical reproducibility. Consequently, appropriate mobile phase selection is a major concern in achieving accurate, precise, and efficient analytical methods. However, to date, no review article has comprehensively compiled and discussed the effect of mobile phase variations specifically on dexamethasone analysis using HPLC. This review article aims to evaluate the effect of variations in mobile phase composition in HPLC analytical methods on the quality of dexamethasone analysis. A literature search was conducted using Google Scholar, PubMed, and Scopus databases, with inclusion criteria consisting of full-text articles published between 2015 and 2025 in Indonesian or English. Based on the selection and screening process, ten articles met the eligibility criteria and were included for further analysis. The results of this review indicate that mobile phase composition plays a crucial role in chromatographic separation performance and method validation parameters. Mobile phases containing a high proportion of organic solvents, particularly acetonitrile, tend to produce shorter retention times, improved peak symmetry, and sharper peak shapes. Meanwhile, the addition of buffer systems to the mobile phase improves pH stability, sensitivity, and linearity.
Co-Authors Ahmad Maulana Al Fatah Anisah Putri Yuana Sari Fajrina Rizqi Riyadi Ihsanti Dwi Rahayu Ihsanti Dwi Rahayu Marshanda Nikita Muhammad Iqbal Triyandi, Ramadhan